CAZyme Information: MGYG000000554_00808

Basic Information

• Species: Campylobacter fetus
• Lineage: Bacteria; Campylobacterota; Campylobacteria; Campylobacterales; Campylobacteraceae; Campylobacter; Campylobacter fetus
• CAZyme ID: MGYG000000554_00808
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
645		72622.63	5.8574

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000554	1538481	MAG	China	Asia

• Gene Location: Start: 336; End: 2273 Strand: -

Full Sequence      

MKHIFGFFTIIAIAIFAALIYFYSQIRVDISAIVEYKPKLTTQIFDRNGDLVANVFDEEN
RQYAKYQEIPPRVVEALVAVEDTSFFEHGGINVEAIFRAAIKDIKAMSLVEGASTLTQQL
IKNMVLTRDKKFTRKLKEVILAFKIEEDLTKEEIIERYLNQVYFGHGYYGIKTAALGYFK
KELNELTIKETAILVGLPKAPSNYDPTRHIDLSLSRANGVITRLYALGWISENEYAQALK
ETPVVYDETLTQNRAPYLVDETLKEAYKIFPDIKYGGYKITLNADLKVQEIAQNALKFGY
NEILKRDKNADQNYLNGAMIVTNPANGEILALVGGIDYAKSNFNRATQSERQPGSSFKPF
IYQIALDLGYSPMSKVADISRVFENVNRSEEDKDWKPKNYGGNFEGYITLKHALRQSRNL
ATINLLNSIGLDVVQQKLSYFGFNNIPQNLSIALGSFGVSLINFSEYYSMFAGLGEQSKS
RLIKSIESTNGTLTTYEQESSKIIDPQQAYLMIDMLKDVVNAGTGRNAKVEGIEVAGKTG
TTNNNVDAWFCGFTPEVQAIIWYGNDNNLPMRKIEGGGRTAAPVFKEFMTNYIEAFPQTK
RKFETPNGVYHKIYEGIDEIYTSTSPLPSQKTDAISTQESDGLIF

Enzyme Prediction     

No EC number prediction in MGYG000000554_00808.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	49	224	4.6e-63	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG5009	MrcA	0.0	19	609	27	733	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	60	594	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	20	640	37	646	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG4953	PbpC	6.50e-94	40	606	35	571	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	8.46e-94	43	609	49	799	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ABK81767.1	0.0	1	645	1	645
QMS67842.1	0.0	1	645	1	645
QMS60118.1	0.0	1	645	1	645
QNH08997.1	0.0	1	645	1	645
QMS66131.1	0.0	1	645	1	645

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	2.79e-89	30	589	9	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.44e-82	43	597	22	720	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	4.05e-67	38	591	142	692	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	5.60e-67	38	591	163	713	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3FWL_A	1.04e-64	38	591	146	696	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O87626	4.81e-103	29	609	37	719	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O66874	1.33e-102	11	606	11	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P38050	3.30e-99	10	606	15	616	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P0A0Z5	2.34e-97	29	589	37	702	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	2.34e-97	29	589	37	702	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999484	0.000489	0.000040	0.000003	0.000002	0.000018

TMHMM  Annotations     

start	end
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