logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000000592_00563

You are here: Home > Sequence: MGYG000000592_00563

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; UBA932; RC9;
CAZyme ID MGYG000000592_00563
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
382 MGYG000000592_47|CGC1 41547.47 9.0625
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000592 2977283 MAG Madagascar Africa
Gene Location Start: 2930;  End: 4078  Strand: -

Full Sequence      Download help

MEYKALRVII  SGGGTGGHIF  PAVSIANKLK  ELNPETEILF  VGAEGKMEME  KVPAAGYRIV60
GLPIVGLQRQ  LSLKNILNDL  CVPFKVLASL  RKARKIVREF  KPQIAVGVGG  YASAPLLWAA120
TGMGIPALIQ  EQNGFAGLTN  KKLGKRVQRI  CVAYEGMERF  FPADRIVMTG  NPIRSIIVPA180
TPEMREQGIN  EYGLDPSRKH  IFIVGGSLGS  SRFNQCMRKW  ISDGCPGIDG  VDVLWQCGKY240
YKAGVDEFMA  DQRAKNPEAL  KHIHYSDFIG  RMELAYAAAD  VVISRSGASS  VSELCAARKA300
VIFIPSPNVA  EDHQTHNAMA  LVKKDAAVIV  KDSNAMEKMI  PTALELLGQP  ERIAALEENA360
GKMALPDAAG  KIAEEIYRLV  KE382

Enzyme Prediction      help

No EC number prediction in MGYG000000592_00563.

CAZyme Signature Domains help

Created with Snap1938577695114133152171191210229248267286305324343362201368GT28
Family Start End Evalue family coverage
GT28 201 368 4.8e-43 0.9872611464968153

CDD Domains      download full data without filtering help

Created with Snap19385776951141331521711912102292482672863053243433627381murG7375GT28_MurG7382MurG7376murG8150Glyco_transf_28
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 9.22e-132 7 381 3 356
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 6.83e-125 7 375 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 3.57e-101 7 382 2 357
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 8.09e-89 7 376 2 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam03033 Glyco_transf_28 2.52e-34 8 150 1 137
Glycosyltransferase family 28 N-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.

CAZyme Hits      help

Created with Snap19385776951141331521711912102292482672863053243433624382AGY53130.1|GT284381ARS35890.1|GT284381AKD05256.1|GT285382QGA27338.1|GT285382QQT52372.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
AGY53130.1 2.02e-149 4 382 2 368
ARS35890.1 5.22e-135 4 381 6 370
AKD05256.1 4.24e-134 4 381 6 370
QGA27338.1 3.00e-133 5 382 2 366
QQT52372.1 1.25e-132 5 382 2 366

PDB Hits      download full data without filtering help

Created with Snap193857769511413315217119121022924826728630532434336213811F0K_A73813S2U_A23797D1I_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
1F0K_A 4.81e-49 1 381 2 355
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
3S2U_A 6.55e-43 7 381 4 356
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 3.48e-42 2 379 6 365
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]

Swiss-Prot Hits      download full data without filtering help

Created with Snap19385776951141331521711912102292482672863053243433625382sp|Q5LIJ7|MURG_BACFN5382sp|Q64ZM1|MURG_BACFR4380sp|A6LEU3|MURG_PARD86379sp|A6L071|MURG_PHOV84381sp|Q8A258|MURG_BACTN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q5LIJ7 3.64e-131 5 382 13 379
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) OX=272559 GN=murG PE=3 SV=2
Q64ZM1 3.64e-131 5 382 13 379
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=murG PE=3 SV=1
A6LEU3 2.60e-128 4 380 2 365
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) OX=435591 GN=murG PE=3 SV=1
A6L071 6.83e-128 6 379 5 366
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) OX=435590 GN=murG PE=3 SV=1
Q8A258 1.81e-124 4 381 3 369
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000077 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000592_00563.