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CAZyme Information: MGYG000000610_00791
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Alphaproteobacteria; RF32; CAG-239; CAAFZY01; | |||||||||||
| CAZyme ID | MGYG000000610_00791 | |||||||||||
| CAZy Family | CE11 | |||||||||||
| CAZyme Description | UDP-3-O-acyl-N-acetylglucosamine deacetylase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 58516; End: 59385 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CE11 | 3 | 275 | 2.6e-95 | 0.992619926199262 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK13186 | lpxC | 3.83e-141 | 1 | 283 | 2 | 281 | UDP-3-O-acyl-N-acetylglucosamine deacetylase. |
| pfam03331 | LpxC | 1.15e-131 | 3 | 276 | 1 | 271 | UDP-3-O-acyl N-acetylglycosamine deacetylase. The enzymes in this family catalyze the second step in the biosynthetic pathway for lipid A. |
| COG0774 | LpxC | 3.24e-112 | 1 | 283 | 2 | 284 | UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell wall/membrane/envelope biogenesis]. |
| TIGR00325 | lpxC | 2.14e-85 | 1 | 283 | 1 | 280 | UDP-3-0-acyl N-acetylglucosamine deacetylase. UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase from E. coli , LpxC, was previously designated EnvA. This enzyme is involved in lipid-A precursor biosynthesis. It is essential for cell viability. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides] |
| PRK13188 | PRK13188 | 1.98e-81 | 3 | 282 | 5 | 306 | bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QPL34792.1 | 2.50e-76 | 3 | 283 | 24 | 303 |
| AJD53288.1 | 2.50e-76 | 3 | 283 | 24 | 303 |
| AUG53807.1 | 1.42e-72 | 3 | 283 | 24 | 303 |
| QKS51614.1 | 2.10e-72 | 1 | 282 | 11 | 291 |
| QPO10975.1 | 5.84e-72 | 1 | 283 | 22 | 303 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5U39_A | 2.56e-62 | 3 | 283 | 6 | 285 | Pseudomonasaeruginosa LpxC in complex with CHIR-090 [Pseudomonas aeruginosa PAO1] |
| 4J3D_A | 2.71e-62 | 3 | 283 | 4 | 283 | Pseudomonasaeruginosa LpxC in complex with a hydroxamate inhibitor [Pseudomonas aeruginosa PAO1],4J3D_B Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor [Pseudomonas aeruginosa PAO1] |
| 5U3B_A | 2.87e-62 | 3 | 283 | 4 | 283 | Pseudomonasaeruginosa LpxC in complex with NVS-LPXC-01 [Pseudomonas aeruginosa PAO1],5U3B_B Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01 [Pseudomonas aeruginosa PAO1],6MAE_A CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide [Pseudomonas aeruginosa PAO1] |
| 7K99_A | 3.23e-62 | 3 | 283 | 4 | 283 | CrystalStructure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 [Pseudomonas aeruginosa PAO1],7K99_C Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 [Pseudomonas aeruginosa PAO1],7K9A_A Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor [Pseudomonas aeruginosa PAO1],7K9A_C Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor [Pseudomonas aeruginosa PAO1] |
| 6MO4_A | 3.23e-62 | 3 | 283 | 8 | 287 | Co-Crystalstructure of P. aeruginosa LpxC-50067 complex [Pseudomonas aeruginosa PAO1] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| B0US73 | 1.15e-68 | 3 | 289 | 4 | 290 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Histophilus somni (strain 2336) OX=228400 GN=lpxC PE=3 SV=1 |
| Q7VMY6 | 1.68e-68 | 3 | 285 | 4 | 289 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Haemophilus ducreyi (strain 35000HP / ATCC 700724) OX=233412 GN=lpxC PE=3 SV=1 |
| Q0I1C7 | 2.30e-68 | 3 | 289 | 4 | 290 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Haemophilus somnus (strain 129Pt) OX=205914 GN=lpxC PE=3 SV=1 |
| Q9CPA5 | 6.50e-68 | 3 | 285 | 4 | 288 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Pasteurella multocida (strain Pm70) OX=272843 GN=lpxC PE=3 SV=1 |
| Q3A225 | 5.84e-67 | 3 | 285 | 4 | 283 | UDP-3-O-acyl-N-acetylglucosamine deacetylase OS=Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) OX=338963 GN=lpxC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.938328 | 0.022145 | 0.039392 | 0.000054 | 0.000044 | 0.000069 |