CAZyme Information: MGYG000000696_00433

Basic Information

• Species: Parabacteroides sp900549585
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides sp900549585
• CAZyme ID: MGYG000000696_00433
• CAZy Family: GH33
• CAZyme Description: Sialidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
401		44703.66	5.7694

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000696	3184747	MAG	Kazakhstan	Asia

• Gene Location: Start: 74051; End: 75256 Strand: -

Full Sequence      

MQKESLMKINRHIHQCLFLGASLLFASCSQQETNQETVVFSSGEDGYKSYRIPAIIQLPK
GDLLAFCEGRVDGAGDFGNIQIVMKRSHDNGKTWSAIQTVASNGTLQVCNPAPVFDTMDP
DYPDGRIFLFYNTGNVSEPEVLKGNGFKQCWYVSSSDKGQSWSDPVEITKDVFLANRPDI
DSLYNHPEDWRYYANTPGHAIQLQEGEHKGRIYVAANHSYGDPQPNGKHYIAHGFYTDNH
GKSFSLSNNIDYPGSNESMAVELSNGTLMMNSRNQQGNKKARIVTLSHDGGTTWEKPTFD
TTLIDPVCQGSIVALGEKDGKSIIAFCNNADTLNRNNLTLRISYDNGQNWSKSYLIYGND
SLPEKNDYSAYSDITLTNEGKVGILYEKDNYSKIVYTTIKP

Enzyme Prediction     

No EC number prediction in MGYG000000696_00433.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH33	34	395	6.2e-91	0.9619883040935673

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	2.21e-104	37	399	1	338	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	3.01e-35	61	384	1	280	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
COG4409	NanH	1.13e-14	35	387	260	643	Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QEM10620.1	3.91e-151	22	397	11	383
QRR01369.1	1.48e-150	36	399	20	381
ACT94235.1	1.89e-149	36	400	22	384
QEC54482.1	4.79e-148	21	400	30	409
QNA46247.1	5.79e-148	39	400	27	384

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1EUR_A	1.44e-32	33	387	10	344	Sialidase[Micromonospora viridifaciens],1EUS_A Sialidase Complexed With 2-Deoxy-2,3-Dehydro-N- Acetylneuraminic Acid [Micromonospora viridifaciens]
1W8N_A	2.37e-32	33	387	6	340	Contributionof the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens. [Micromonospora viridifaciens],1W8O_A Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens [Micromonospora viridifaciens]
1EUT_A	2.09e-31	33	387	10	344	Sialidase,Large 68kd Form, Complexed With Galactose [Micromonospora viridifaciens],1EUU_A Sialidase Or Neuraminidase, Large 68kd Form [Micromonospora viridifaciens]
1WCQ_A	6.98e-31	33	387	6	340	Mutagenesisof the Nucleophilic Tyrosine in a Bacterial Sialidase to Phenylalanine. [Micromonospora viridifaciens],1WCQ_B Mutagenesis of the Nucleophilic Tyrosine in a Bacterial Sialidase to Phenylalanine. [Micromonospora viridifaciens],1WCQ_C Mutagenesis of the Nucleophilic Tyrosine in a Bacterial Sialidase to Phenylalanine. [Micromonospora viridifaciens]
2BZD_A	1.29e-30	33	387	6	340	Galactoserecognition by the carbohydrate-binding module of a bacterial sialidase. [Micromonospora viridifaciens],2BZD_B Galactose recognition by the carbohydrate-binding module of a bacterial sialidase. [Micromonospora viridifaciens],2BZD_C Galactose recognition by the carbohydrate-binding module of a bacterial sialidase. [Micromonospora viridifaciens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q02834	1.38e-30	33	387	52	386	Sialidase OS=Micromonospora viridifaciens OX=1881 GN=nedA PE=1 SV=1
P15698	3.73e-26	35	387	37	380	Sialidase OS=Paeniclostridium sordellii OX=1505 PE=1 SV=1
A5PF10	1.83e-24	36	388	62	396	Sialidase-1 OS=Sus scrofa OX=9823 GN=NEU1 PE=3 SV=1
O35657	5.87e-24	27	388	46	389	Sialidase-1 OS=Mus musculus OX=10090 GN=Neu1 PE=1 SV=1
A6BMK7	6.25e-24	36	388	61	395	Sialidase-1 OS=Bos taurus OX=9913 GN=NEU1 PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000015	0.000406	0.999607	0.000003	0.000001	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000696_00433.