CAZyme Information: MGYG000000699_00428

Basic Information

• Lineage: Bacteria; Firmicutes; Bacilli; Erysipelotrichales; Erysipelotrichaceae; Bulleidia
• CAZyme ID: MGYG000000699_00428
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
783		87083.72	4.3167

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000699	1671307	MAG	Kazakhstan	Asia

• Gene Location: Start: 4959; End: 7310 Strand: -

Full Sequence      

MQLVKLTYFFVDTGNEATSVTSEKNVEYKVQQIAMALELEKQASKKEIFEMYLNKMNFGG
SGNIRGVEKASEYYFNKRVTDLNLSESALLAGIINSPYYYDPMNYLDYSTQRRNVVLALM
LRHGYITQEEYSLAKSINVEDLLYDHSTDNVENGNPYQAYIDAVLFEAEQITGQDPFTVA
MDIHTAMNPEAQSLSDAICAGQYDDVWFPADQVELGFVTMNNQNGEVIAIGGGRNYSSNG
GAGLLNHGTAVYHSPGSCVKPFMSYALAFENLGWATSHVVCDEPVGSREWIFSNFDGVYR
GDVTLEYAIQTSLNTPAIAAMYEEFETMGYDTVAKYVESLDFSRYSYDMFDVAWAIGGNE
FYASPEEIAQAHSMLINGGKLYKAHTIRTITYRSGTKDPITVSELEEYQPKQVLSPQAAY
LSSYMMNKVVWSSEYNYAQILQRSYATYAKSGTSDYGDDAVQYGIPEGARKDKWMVCSTS
EYTTAVWNGFDKADANVQSWFSDDWDSLNIPGRVCSAMLDQLNADHTPADVQQPDGISSI
THIKGVYPYVSTIEGMDSEYVTTGLIKTEFNKLNSPQGADSVKDLTTFTASYSGNDQLIP
SDGTLTLKWADYPDADKLKVAEQEKDISLKYGDTVIRAATGKRMFDYSWVYGPIQYKARL
EGSDGSSQELATDQSTYTQTVSLSPGITYTVKGYYGYEKLGGNSNEVTAQVFTVPETIQI
PVYTTSQEYKDWAEANGIKVDITESHGAKDTSVTYNNVDITGITVNKTVVQTGKINVVIP
YQK

Enzyme Prediction     

No EC number prediction in MGYG000000699_00428.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	1	120	3.6e-32	0.5988700564971752

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	5.85e-101	1	494	59	505	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.34e-93	1	492	134	573	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	1.21e-54	1	492	124	693	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.17e-50	20	491	212	658	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	7.87e-48	29	548	131	602	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QRG87111.1	9.56e-202	1	752	139	856
APO28576.1	2.77e-191	1	565	149	711
QIK69989.1	2.75e-136	1	738	164	903
AMC93213.1	3.01e-136	1	737	177	904
QRG86014.1	8.30e-135	1	595	131	700

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	1.09e-51	20	492	92	559	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	5.88e-48	20	492	101	568	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
3ZG8_B	1.37e-43	38	494	2	436	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	9.98e-39	38	494	2	436	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
2C5W_B	6.76e-28	157	537	3	375	PENICILLIN-BINDINGPROTEIN 1A (PBP-1A) ACYL-ENZYME COMPLEX (CEFOTAXIME) FROM STREPTOCOCCUS PNEUMONIAE [Streptococcus pneumoniae R6]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39793	4.06e-61	20	609	160	727	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
Q8DR59	4.55e-53	2	537	128	640	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
Q04707	4.55e-53	2	537	128	640	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q00573	5.98e-52	2	530	129	634	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
P38050	1.48e-41	20	496	132	576	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000041	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000699_00428.