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CAZyme Information: MGYG000000759_00648
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Corynebacterium; | |||||||||||
| CAZyme ID | MGYG000000759_00648 | |||||||||||
| CAZy Family | GT53 | |||||||||||
| CAZyme Description | putative arabinosyltransferase C | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1626; End: 5087 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT53 | 26 | 1146 | 0 | 0.9952335557673975 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam04602 | Arabinose_trans | 0.0 | 211 | 674 | 1 | 459 | Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
| pfam14896 | Arabino_trans_C | 4.30e-175 | 723 | 1146 | 1 | 384 | EmbC C-terminal domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate. |
| pfam17689 | Arabino_trans_N | 6.26e-52 | 50 | 207 | 1 | 155 | Arabinosyltransferase concanavalin like domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
| cd06173 | MFS_MefA_like | 0.004 | 451 | 638 | 145 | 303 | Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QQN47820.1 | 0.0 | 1 | 1153 | 1 | 1153 |
| QQU80795.1 | 0.0 | 1 | 1153 | 1 | 1152 |
| QQA99064.1 | 0.0 | 1 | 1153 | 1 | 1152 |
| QRQ67554.1 | 0.0 | 1 | 1153 | 1 | 1155 |
| VEH71854.1 | 0.0 | 19 | 1153 | 3 | 1138 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7BVE_A | 1.33e-244 | 27 | 1147 | 16 | 1073 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVE_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155] |
| 7BVH_A | 3.21e-244 | 27 | 1147 | 29 | 1086 | Crystalstructure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155],7BVH_B Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155] |
| 7BWR_A | 4.79e-241 | 27 | 1149 | 27 | 1082 | Mycobacteriumsmegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BWR_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BX8_A Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155],7BX8_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155] |
| 6X0O_A | 7.78e-241 | 27 | 1149 | 27 | 1082 | Single-ParticleCryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis [Mycolicibacterium smegmatis MC2 155] |
| 7BVC_B | 8.26e-241 | 27 | 1149 | 27 | 1082 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q50393 | 3.69e-241 | 27 | 1147 | 16 | 1073 | Probable arabinosyltransferase C OS=Mycolicibacterium smegmatis OX=1772 GN=embC PE=3 SV=2 |
| Q50395 | 1.32e-240 | 27 | 1149 | 27 | 1082 | Probable arabinosyltransferase B OS=Mycolicibacterium smegmatis OX=1772 GN=embB PE=3 SV=3 |
| Q7TVN4 | 4.25e-232 | 27 | 1146 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) OX=233413 GN=embC PE=3 SV=1 |
| P9WNL5 | 1.19e-231 | 27 | 1146 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=embC PE=1 SV=1 |
| P9WNL4 | 1.68e-231 | 27 | 1146 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=embC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999933 | 0.000082 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
TMHMM Annotations download full data without filtering help
| start | end |
|---|---|
| 28 | 50 |
| 218 | 235 |
| 255 | 274 |
| 323 | 345 |
| 362 | 379 |
| 415 | 437 |
| 457 | 479 |
| 526 | 543 |
| 550 | 572 |
| 582 | 604 |
| 611 | 633 |
| 648 | 670 |
| 703 | 725 |