CAZyme Information: MGYG000000836_01203

Basic Information

• Species: UBA10281 sp000437515
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; Borkfalkiaceae; UBA10281; UBA10281 sp000437515
• CAZyme ID: MGYG000000836_01203
• CAZy Family: GH2
• CAZyme Description: Beta-glucuronidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
584		66804.84	5.5946

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000836	1764500	MAG	China	Asia

• Gene Location: Start: 17376; End: 19130 Strand: +

Full Sequence      

MLYPQSNEKRSVLNLNGVWNYKFVSDDFIPGEKSFDVSPMAVPASMNDILTDRDKANYIG
KVLYEREFSLPADEKVSYRLRIGSVSHKSEVYLNGVKIGEGFNGYLPVDLPLENLKGKNR
LSVVIDNRLTNHTLPMGELVPADEIRLWKTTGGEAVIDASKYFSGQKQVIKFDFYNFTGI
HRDVLVYSLPKNGIEDVVIQTVVGGDYEKIKVDVKTSGKVVKYTIFDDDKAILASKTGDI
TLKNPKLWSCENPHLYTLRVETENDCYEQTFGVRKVSFDEKGVMLNDKYVYFKGFGKHED
FFISGKGNNTAVNVRDFELLKWINANSFRTSHYPYAEEILDLADRYGIMVIDECPAAGVG
FWGGYTFGKGRVDEELLKIHKASLSTMIDRDKNHPCVVMISLANETATYEEASRPYYKEL
YDLAHSLTDLPVTLVESTKSFEVSHVSDMSDIICVNRYYGWYDEPSNIRAIEPLILADIG
EYYEKFRKPMMLTEFGADTIEGFHSVQSEMFSEEFQRDVLKETCRVLDTIPYVIGEQVWN
FADFKTRDGVMRARGNRKGVFTRERQPKTAAFFLKERWANKNEK

Enzyme Prediction     

EC	3.2.1.31

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	5	579	3.9e-95	0.6183510638297872

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK10150	PRK10150	0.0	1	582	1	596	beta-D-glucuronidase; Provisional
COG3250	LacZ	7.24e-105	1	583	1	600	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
pfam02836	Glyco_hydro_2_C	3.38e-74	280	580	4	299	Glycosyl hydrolases family 2, TIM barrel domain. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.
PRK10340	ebgA	4.20e-32	63	407	112	451	cryptic beta-D-galactosidase subunit alpha; Reviewed
PRK09525	lacZ	2.12e-27	64	405	124	462	beta-galactosidase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACI18585.1	1.17e-160	1	579	1	570
ACK42813.1	2.07e-158	1	578	1	568
ADU28966.1	6.48e-156	1	578	1	588
ADQ45036.1	2.49e-152	1	581	1	591
ARK29794.1	3.85e-145	1	580	1	593

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6XXW_A	8.17e-162	1	579	21	590	Structureof beta-D-Glucuronidase for Dictyoglomus thermophilum. [Dictyoglomus thermophilum H-6-12]
6U7J_A	1.24e-151	1	578	10	590	UnculturedClostridium sp. Beta-glucuronidase [uncultured Clostridium sp.],6U7J_B Uncultured Clostridium sp. Beta-glucuronidase [uncultured Clostridium sp.],6U7J_C Uncultured Clostridium sp. Beta-glucuronidase [uncultured Clostridium sp.],6U7J_D Uncultured Clostridium sp. Beta-glucuronidase [uncultured Clostridium sp.]
4JKM_A	1.65e-142	1	580	4	594	CrystalStructure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],4JKM_B Crystal Structure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],6CXS_A Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13],6CXS_B Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13]
6LD0_A	2.46e-135	1	579	3	661	ChainA, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1]
6U7I_A	2.50e-134	1	579	1	589	Faecalibacteriumprausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_B Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_C Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_D Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O97524	3.31e-120	1	583	27	631	Beta-glucuronidase OS=Felis catus OX=9685 GN=GUSB PE=1 SV=1
P05804	4.71e-120	1	582	1	592	Beta-glucuronidase OS=Escherichia coli (strain K12) OX=83333 GN=uidA PE=1 SV=2
O18835	9.25e-120	1	583	27	631	Beta-glucuronidase OS=Canis lupus familiaris OX=9615 GN=GUSB PE=1 SV=1
P12265	1.46e-117	1	583	27	628	Beta-glucuronidase OS=Mus musculus OX=10090 GN=Gusb PE=1 SV=2
Q4FAT7	3.23e-117	1	583	28	632	Beta-glucuronidase OS=Sus scrofa OX=9823 GN=GUSB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000046	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000836_01203.