dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Prevotella sp900545525

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotella; Prevotella sp900545525

CAZyme ID

MGYG000000852_00208

CAZy Family

GT2

CAZyme Description

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
419		47706.57	7.8307

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000852	2918004	MAG	China	Asia

Gene Location

Start: 73896; End: 75155 Strand: +

Enzyme Prediction help

No EC number prediction in MGYG000000852_00208.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GT2	4	137	9.2e-23	0.7764705882352941

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06433	GT_2_WfgS_like	9.51e-63	4	205	1	202	WfgS and WfeV are involved in O-antigen biosynthesis. Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
cd04647	LbH_MAT_like	6.80e-37	298	401	2	109	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.
cd03349	LbH_XAT	3.42e-28	299	404	3	127	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.
PRK10502	PRK10502	4.94e-27	260	405	34	179	putative acyl transferase; Provisional
cd03357	LbH_MAT_GAT	6.71e-27	254	401	21	169	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUB91771.1	7.89e-159	2	419	4	421
AXV50072.1	7.89e-159	2	419	4	421
QUI93290.1	7.89e-159	2	419	4	421
QJR60740.1	6.43e-55	2	254	4	245
QJR54460.1	6.43e-55	2	254	4	245

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1KQA_A	7.58e-12	269	401	47	182	GalactosideAcetyltransferase In Complex With Coenzyme A [Escherichia coli],1KQA_B Galactoside Acetyltransferase In Complex With Coenzyme A [Escherichia coli],1KQA_C Galactoside Acetyltransferase In Complex With Coenzyme A [Escherichia coli],1KRR_A Galactoside Acetyltransferase in Complex with Acetyl-Coenzyme A [Escherichia coli],1KRR_B Galactoside Acetyltransferase in Complex with Acetyl-Coenzyme A [Escherichia coli],1KRR_C Galactoside Acetyltransferase in Complex with Acetyl-Coenzyme A [Escherichia coli],1KRU_A Galactoside Acetyltransferase in Complex with IPTG and Coenzyme A [Escherichia coli],1KRU_B Galactoside Acetyltransferase in Complex with IPTG and Coenzyme A [Escherichia coli],1KRU_C Galactoside Acetyltransferase in Complex with IPTG and Coenzyme A [Escherichia coli],1KRV_A Galactoside Acetyltransferase in Complex with CoA and PNP-beta-Gal [Escherichia coli],1KRV_B Galactoside Acetyltransferase in Complex with CoA and PNP-beta-Gal [Escherichia coli],1KRV_C Galactoside Acetyltransferase in Complex with CoA and PNP-beta-Gal [Escherichia coli]
6JVU_A	5.46e-10	299	407	151	258	ChainA, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578],6JVU_B Chain B, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578],6JVU_C Chain C, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578],6JVU_D Chain D, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578],6JVU_E Chain E, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578],6JVU_F Chain F, Serine acetyltransferase [Klebsiella pneumoniae MGH 78578]
7E3Y_A	5.46e-10	299	407	151	258	ChainA, Serine acetyltransferase [Salmonella enterica subsp. enterica serovar Typhimurium],7E3Y_B Chain B, Serine acetyltransferase [Salmonella enterica subsp. enterica serovar Typhimurium],7E3Y_C Chain C, Serine acetyltransferase [Salmonella enterica subsp. enterica serovar Typhimurium]
1T3D_A	1.41e-09	299	407	159	266	Crystalstructure of Serine Acetyltransferase from E.coli at 2.2A [Escherichia coli],1T3D_B Crystal structure of Serine Acetyltransferase from E.coli at 2.2A [Escherichia coli],1T3D_C Crystal structure of Serine Acetyltransferase from E.coli at 2.2A [Escherichia coli]
5U2K_A	3.08e-09	275	408	72	188	ChainA, Galactoside O-acetyltransferase [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P9WMX8	6.16e-15	3	101	7	106	Uncharacterized glycosyltransferase MT1564 OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT1564 PE=3 SV=1
P9WMX9	6.16e-15	3	101	7	106	Uncharacterized glycosyltransferase Rv1514c OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv1514c PE=1 SV=1
P71239	7.75e-14	1	202	1	201	Putative colanic acid biosynthesis glycosyl transferase WcaE OS=Escherichia coli (strain K12) OX=83333 GN=wcaE PE=4 SV=2
Q09707	3.87e-12	318	401	115	201	Putative acetyltransferase C18B11.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC18B11.09c PE=3 SV=2
P07464	4.15e-11	269	401	47	182	Galactoside O-acetyltransferase OS=Escherichia coli (strain K12) OX=83333 GN=lacA PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000058	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000852_00208.

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