CAZyme Information: MGYG000000870_00311

Basic Information

• Species: Akkermansia sp004167605
• Lineage: Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia sp004167605
• CAZyme ID: MGYG000000870_00311
• CAZy Family: GH84
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
988		107574.58	9.6082

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000870	3134704	MAG	United States	North America

• Gene Location: Start: 353061; End: 356027 Strand: -

Full Sequence      

MMAVTALGAGLALPLFAQSSSSTSSAATSGHAKKASRMPVYPIPQKMTRSGGSVTVPALK
LIGVKDAPTMNALKSMFALSPNGFPVQMSIIKGSKKPAGNIPQKAGAYSLSVTPQGIRMT
GYDDEGLFYAAQTLLQLAEKTPSGVTVPQVEVLDWPDVPFRGTIEGFYGLPWGQEGRISQ
FKFYGKYKMNTYIYGPKDDVFHGFSKRWREPYPADMAKDLKELVKIAKENKVNFVWAVHP
GADIHWGEADRKAAVKKFEMMYDLGFRSFAVFFDDIGGEGAKPEGQVEFLNYLNKEFIHK
KPDVTPLIVCPTAYAGNGGRYHEVMGEHLDKDIGIMWTGSGIVSDIRTPALKGINKFLQR
PAFIWWNFPVTDYVRHALFLGRTYGVDADAMPYMQGFASNPMDKPEASKISLFSVANMTW
NAKAYDSDKTWKDSIRILFPGCASAMQTFANHNSDGGPSGHNYRKEESVEIAPVVEQVLD
LCRRGAKVADNKAFERLKAEFAKMAQAPDIIRAKANNPAFVAEVEPWLIQFESLGKAGMN
SMQMLEATEAGNSSAALNYAMEAACLLAEMQRYSKEISKVINKHVTEVTKKNSPWQTAVK
PSELVMAPAVRELLDLGSTPVLSRVSGRVVGRVKPYVSTKLKNGIEKMLDDDPESYFYCK
EVQKKGDFFGVDLGVPREIRTVSIVMGRNDSDKDAVNKGQLEVSMDGQSWSPLMPETSGV
RVEYQGSGKKGRFVRYRATVQGVPGGKPDVWTAIRDFKVNAPAAPSVLTDAPAFKGAVAE
TGDTDISLKRIMEVHPLPPRKSLGLQIPAGAAVESASINLKTPDIKWAKLFISMDGKGWT
EVPLKADGSAEIGGVVKGVKLVNAGPSPQEVTLEEFKLNLANKGKKDSNSGAAGDFNLAT
FLSVDLSPERVEIPCTSPRANSAIVLSDGREATVQACGADGRWVPVGSLGKGKKVTTLNL
KSVRKPVKAIGLTGKKDTSVNIFEVIWK

Enzyme Prediction     

No EC number prediction in MGYG000000870_00311.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH84	161	450	1.8e-100	0.9932203389830508

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam07555	NAGidase	1.14e-144	161	449	1	293	beta-N-acetylglucosaminidase. This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.
pfam02838	Glyco_hydro_20b	5.55e-17	37	154	1	123	Glycosyl hydrolase family 20, domain 2. This domain has a zincin-like fold.
COG3525	Chb	5.81e-08	85	162	188	265	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].
pfam00754	F5_F8_type_C	1.58e-07	643	739	12	113	F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.
cd00057	FA58C	0.002	657	713	36	92	Substituted updates: Jan 31, 2002

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QWO94866.1	0.0	1	988	9	997
QWO92335.1	0.0	1	988	9	997
QWO89858.1	0.0	1	988	9	997
QWP69675.1	0.0	1	988	9	997
QWO85032.1	0.0	1	988	9	997

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2J4G_A	1.17e-146	40	713	4	670	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor [Bacteroides thetaiotaomicron VPI-5482],2J4G_B Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor [Bacteroides thetaiotaomicron VPI-5482]
2JIW_A	1.21e-146	40	713	5	671	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with 2- Acetylamino-2-deoxy-1-epivalienamine [Bacteroides thetaiotaomicron VPI-5482],2JIW_B Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with 2- Acetylamino-2-deoxy-1-epivalienamine [Bacteroides thetaiotaomicron VPI-5482]
2J47_A	1.21e-146	40	713	5	671	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor [Bacteroides thetaiotaomicron VPI-5482],2W4X_A BtGH84 in complex with STZ [Bacteroides thetaiotaomicron VPI-5482],2W66_A BtGH84 in complex with HQ602 [Bacteroides thetaiotaomicron VPI-5482],2W66_B BtGH84 in complex with HQ602 [Bacteroides thetaiotaomicron VPI-5482],2W67_A BtGH84 in complex with FMA34 [Bacteroides thetaiotaomicron VPI-5482],2W67_B BtGH84 in complex with FMA34 [Bacteroides thetaiotaomicron VPI-5482],2WCA_A BtGH84 in complex with n-butyl pugnac [Bacteroides thetaiotaomicron VPI-5482],2XJ7_A BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine [Bacteroides thetaiotaomicron VPI-5482],2XJ7_B BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine [Bacteroides thetaiotaomicron VPI-5482],2XM1_A BtGH84 in complex with N-acetyl gluconolactam [Bacteroides thetaiotaomicron VPI-5482],2XM1_B BtGH84 in complex with N-acetyl gluconolactam [Bacteroides thetaiotaomicron VPI-5482],2XM2_A BtGH84 in complex with LOGNAc [Bacteroides thetaiotaomicron VPI-5482],2XM2_B BtGH84 in complex with LOGNAc [Bacteroides thetaiotaomicron VPI-5482],4UR9_A Structure of ligand bound glycosylhydrolase [Bacteroides thetaiotaomicron],4UR9_B Structure of ligand bound glycosylhydrolase [Bacteroides thetaiotaomicron],5FKY_A Structure of a hydrolase bound with an inhibitor [Bacteroides thetaiotaomicron],5FKY_B Structure of a hydrolase bound with an inhibitor [Bacteroides thetaiotaomicron],5FL0_A Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL0_B Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL1_A Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL1_B Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron]
7K41_A	1.32e-146	40	713	8	674	ChainA, O-GlcNAcase BT_4395 [Escherichia coli K-12]
2VVN_A	1.59e-146	35	713	21	692	BtGH84in complex with NH-Butylthiazoline [Bacteroides thetaiotaomicron VPI-5482],2VVN_B BtGH84 in complex with NH-Butylthiazoline [Bacteroides thetaiotaomicron VPI-5482],2VVS_A BtGH84 structure in complex with PUGNAc [Bacteroides thetaiotaomicron VPI-5482],2X0H_A BtGH84 Michaelis complex [Bacteroides thetaiotaomicron VPI-5482],2X0H_B BtGH84 Michaelis complex [Bacteroides thetaiotaomicron VPI-5482],4AIS_A A complex structure of BtGH84 [Bacteroides thetaiotaomicron VPI-5482],4AIS_B A complex structure of BtGH84 [Bacteroides thetaiotaomicron VPI-5482],7OU8_AAA Chain AAA, O-GlcNAcase BT_4395 [Bacteroides thetaiotaomicron VPI-5482],7OU8_BBB Chain BBB, O-GlcNAcase BT_4395 [Bacteroides thetaiotaomicron VPI-5482]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q89ZI2	8.70e-146	35	713	21	692	O-GlcNAcase BT_4395 OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4395 PE=1 SV=1
Q0TR53	1.49e-83	104	717	129	719	O-GlcNAcase NagJ OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=nagJ PE=1 SV=1
Q8XL08	2.04e-83	104	717	129	719	O-GlcNAcase NagJ OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagJ PE=1 SV=1
P26831	1.72e-54	40	760	41	795	Hyaluronoglucosaminidase OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagH PE=1 SV=2
O60502	5.89e-35	162	420	63	331	Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.559618	0.439580	0.000240	0.000222	0.000171	0.000161

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000870_00311.