CAZyme Information: MGYG000000870_02623

Basic Information

• Species: Akkermansia sp004167605
• Lineage: Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia sp004167605
• CAZyme ID: MGYG000000870_02623
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
935		103291.47	9.9212

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000870	3134704	MAG	United States	North America

• Gene Location: Start: 4170; End: 6977 Strand: +

Full Sequence      

MKLSIIGWFDISYYKNVQYGQDLSMDLRHGTLSFASTIRNIYDKIFPRMGADDKSRKGNA
GSWRERIPDAQPASRARSARRKRQPPRPSYPGLPGEEPRPAVIPGPTRRTAGPRDSSSPY
GAPSPRPRKAPRPAPQVEYDEEKATPERSSRPSGKRRKPGFTIFGALWLVLTMPFRFIGA
LTRNIRWFISWPLRILLSVSFVGIVVGAILVFLYGTISNRYDISEVKSNIPERTVILDRK
NRTIGTLHGENRRRVPLQEVPPIFIDALLLREDNRFYDHGGVDWIGVGRAVAQVIKHKRA
TQGASTLTMQLAKITYNHQERNLHSKLTEVALAKRIEATYSKDEILETYINRIFWGHTFL
GIAAASRGYYDKEPRDLSLSECATLAGIIYGPNDFSPLKHPEEARKVRDIVLGLLKDAGK
ITEVQYAAALAEPIVTHPPQSRSEENYAMDLVRRELDAILEEEDIRLGGLVVHTTLDLDL
QNATLDIINKHMTALESRKDFKKHLASLQARREKRGIVKNKLTTKAEYEAALAAYKAIPA
EQRGKKQPPMPNYIQSAAVVMDNATGALLAVVGGRDAEESKLNRAIQSRRQTGSLFKPFV
YATFFQQGNSADTRISDDRIAHGEIRGAANWSPRNSDGTYRGMKPASFGLILSRNTMSVR
IGNRAGLGNVIQSAELAGFHGNVSKTPALFLGTWEASPLDVASAYSVFANGGVRPTPYII
DHITDSKGQPRFAITKSRRAVYSQRAANITSSILQQVCKPGGTAGRITALGFKAPCGGKT
GTTNNYTNAWFAGYTSNLTCSVWVGFDTATKILEKGYGGTLALPIWTDIMLASQKEGYPS
NAIRTRAASEGQAVLVCRESNQLAHSGCQYAKTAYYETTVGYQAPSKMCEKHIPLAEPGS
EEDIPYAEPLDSSDDNIPLAEPVDETDGIPYATPI

Enzyme Prediction     

No EC number prediction in MGYG000000870_02623.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	242	413	7.9e-58	0.9661016949152542

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	5.86e-164	179	830	5	593	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	4.13e-163	251	830	1	525	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	8.29e-152	196	909	8	788	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.02e-107	242	830	134	679	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
TIGR02073	PBP_1c	1.32e-89	231	869	9	573	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QWO92622.1	0.0	49	935	1	887
QWO92073.1	0.0	49	935	1	887
QWP69962.1	0.0	49	935	1	887
QWO85318.1	0.0	49	935	1	887
QWO95154.1	0.0	49	935	1	887

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	4.36e-83	241	844	28	725	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	2.66e-80	253	830	38	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	8.69e-66	224	826	1	750	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	1.57e-63	244	826	148	686	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	2.14e-63	244	826	169	707	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O87579	1.60e-87	206	844	21	715	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O87626	1.08e-85	202	828	21	699	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
Q5FAC7	2.07e-85	202	830	21	702	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3
O05131	2.07e-85	202	830	21	702	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3
P0A0Z6	2.74e-84	202	830	21	702	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000041	0.000005	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
160	182
195	217