CAZyme Information: MGYG000000892_01080

Basic Information

• Species: CAG-115 sp002492075
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; CAG-115; CAG-115 sp002492075
• CAZyme ID: MGYG000000892_01080
• CAZy Family: GH23
• CAZyme Description: DNA mismatch repair protein MutS

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2743		307360.27	4.5923

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000892	2629881	MAG	Denmark	Europe

• Gene Location: Start: 1072; End: 9303 Strand: -

Full Sequence      

MTSVEKTNQLQEFSNESVSRLWRDTDYYLSFLKTSARLYKYGFADQVLIHAHRPGAVACA
EYGTWSNNDIHRYIKRGAKGIPLIANDKNGRQSIRYVFDFSDTGARDERSKEPFFWEVSP
KNKNAVLEALGASSDNIADALLIKAHELAEEQAEDYLRDLNDSAADTFLEEYDELNLRIR
FTDLLEKSVFFSLCSRCGIDTDNYFDKDDFRGLAEFNGIGAMTVLGTAVSEISEQILRSI
EKTLKTERRKEYERDITENNDRDAAERTGSEFYANGGFTDVSADIGAAGAEGDRNIRENA
AGVSEGTPQGAVSVAASERNAERTFGGDGRNGAAAVGANASPDVGESGSDGAAQSTEPNG
MGRTDQQRETGGGGNDSSRTDIQLNNGGAELDGSAFSMPELDIFDIEPSGGEDGGEAYQL
SLFDTDDTSDIAVEVKEKPKQAELNPALELSITDELMRGSGTEQGKLRISDYYRENKPDV
KEFAKFLKNEYGTYHGRSGLDSGVIRFATYEGKGAKFELEQDGERSEYKLSWEKLAVRTA
ELIKNNEYISAKDIDDFVRSSAWHLKSGLYPAERELNILKRFGADGDGKNPSASFSADKF
DLANADINLQDNAFLAKTEITVNQPELLERLAANGLVPQKNFDGRLLFETDGGKWNRFIL
PDTYGNKWNNIPAETIMRSDETDELVKVLEYITETVMALRQQDAEKELLDNLTAEDFEAG
YDGVAAEGELTAVRMGDFYEFYGEDAELAAELLNINLTSRHGEPMTGFPVHVLEQYESLL
YDKGWELVLREAEELSVEPPAPAKGKYITEYYVCNEYGDPISDAYETWEEADRHLPEFYP
EADYVDGFDTLIDVTAENSLEFNIGFTESGILRQFLDANYPDGNIPFALANELIRYLDEK
AITENMQGYDKTDFEIRAVIDGEEYGYDGRFDVGDGNGEGGGDSVTEHIQRNADWIINTD
SGFFTDEDKALSRSTLDVLVPFLNKHAGLSAEEEKILEKFKAENPIRGKAMSELTAGDVI
KLPSETMLDRNMKPAAVSESYAVVRTANEREISLDTYSDKELTNKTGVAGYLNDWAKHLD
EIGAEYIGKYEELAVKKEKTVVIDLTPREPEHETPNIPVSPMANFTITDENLGAGGAKAK
YKANVEAIKLLQRLESENRQANPDEQEILSRYVGWGGISQAFDENNKAWANEYAELRALL
SPAEYESARASTLNAHYTSPTVINAMYEGLENLGFKTGNVLEPAMGVGNFFGCMPGEMRG
SKLFGVELDSITGRIAKQLYPEADIQIKGFEETAFPDNFFDTAVGNVPFGSYKLSEKRYD
KLNLPIHDHFFAKSLDKVRPGGVIAFVTSKGTLDKESLKFRQYLAQRAELLGAIRLPNNA
FTENAGTEVTSDIIFLQKRDKVLDIDVPDWVNLGKTADGIPVNKYFEQHPEMILGEMKQG
AEFSMHGNENETACVPIDGADLKEQLKAAIANIHGFIPDIVRNEAEEKAAESIPTDTHVR
NFSFTVSDGNIYYRENDEMFLREMPEKTAERIKGMIGIRDCTRELIDCQLYGGSDVEITQ
LQRKLSRLYDNFTKEYGLINARENVRAFSDDSSMPLLSSLEILDEDGNLERKADMFTKRT
IKPREEITHVDTALEALAVSVGEKTGVDIPFMAQLCGKSEKEVIEECCEANAIFELPSFD
PGERGRYVTADEYLSGNIREKRQLALLAAAADNSFMRNADALEQVLPKWLDASEIDVRLG
ATWIDPPVYKQFITELLKTPWYLEKHIKVDFCEYTSEWNIGEKSKDKNNVLANTTYGTTR
ANAYSIIEDTLNLRNTQVYDAVRDDDGKIKYVLNQDETTLAQEKQDAIKQAFKDWIFNDP
ERREQLVNKYNELFNSIRPREYDGSHLRLAGMSPEIKLRPHQLNAIARIVYGGNTLLAHQ
VGAGKTFEMAAAAMESKRLGLCNKPLFAVPNHLTEQWGAEFMRLYPSANILVATGKDFEA
KNRKRLCAKIATGNYDAIIIGHSQLKKIPISPEREQEMLRRQVEDITQGIMALDGQQEAR
FTVKRLESTKKSLMTRLKKLADVAKRDDVITFEELGVDRLFVDEAHEFKNLFLYTKMRNV
AGIGQVEAEKSSDLYNKCQYLDEITDGKGSIFATGTPISNTMSELYTMMRYLQSDTLRNM
RMQNFDAWAANFGEAVTAIELAPEGTGYRAKTRFSKFFNLPELMNIFKEAADIKMSDELG
LDVPEAHFHNIAVLPSELQKEMVQDLSERAALVHQKKVAPDVDNMLKITNDGRKIGLDQR
LMNPDLPDNPASKVNVCVKNVVDIYEKTAENKSTQLIFCDFSTPNGKGFNLYDDIREKLI
AQGVKKEEIAFIHDADSEVKKKELFAKVRSGKVRILLGSTAKCGAGMNVQDKLVALHHLD
CPWRPSDLEQREGRIIRQGNENKEVDIFRYVTEATFDAYLYQTIENKQRFISQIMTSKSP
VRSCEDVDEATLSYAEVKALCAGNPLIKEKMDLDIEVAKLKVLKSSYNSQRYSLEDKIIK
EYPRQISMLEKRIEAYGKDLEHMRTIKDPDEGISMMVIAGKPYTDKEAAGEALASALKVV
KSTTDKYNIGSFKGFDMYLSYNSFSRQFTLDLKREGTHSVVLGDSNAGNITRIENALNSI
EKRIEGSKEQLKTVREQREEAKAELAKPFAREQELTDKLARLAQLNAELNIDGAGKSEIS
ADEKPSVLGEISNLKKQAKEKDKGIGKKPERDDTDKKDGRQAI

Enzyme Prediction     

No EC number prediction in MGYG000000892_01080.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4646	COG4646	6.14e-75	1422	1952	1	540	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
COG4646	COG4646	5.47e-24	2083	2284	434	637	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
pfam01624	MutS_I	4.35e-15	733	806	21	95	MutS domain I. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
PRK05399	PRK05399	1.61e-14	734	805	30	102	DNA mismatch repair protein MutS; Provisional
COG0249	MutS	5.15e-13	734	811	28	101	DNA mismatch repair ATPase MutS [Replication, recombination and repair].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ASV45029.1	0.0	1121	2696	1544	3197
QIW86704.1	0.0	1121	2689	1612	3258
QIW86628.1	0.0	1121	2689	1612	3258
AXF51455.1	0.0	1121	2689	1778	3427
AEY69616.1	0.0	1121	2689	1685	3334

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5AKB_A	1.05e-06	730	805	28	104	MutSin complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_B MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_E MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKC_A MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_B MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_E MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_F MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_I MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_J MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKD_A MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_B MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_E MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_F MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_I MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_J MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12]
7AI6_A	1.08e-06	730	805	28	104	ChainA, DNA mismatch repair protein MutS [Escherichia coli K-12],7AI6_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIB_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIB_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIC_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7AIC_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12]
3K0S_A	1.81e-06	730	805	27	103	ChainA, DNA mismatch repair protein mutS [Escherichia coli K-12],3K0S_B Chain B, DNA mismatch repair protein mutS [Escherichia coli K-12]
1OH5_A	1.81e-06	730	805	28	104	THECRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH5_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH6_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH6_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH7_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH7_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH8_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1OH8_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1W7A_A ATP bound MutS [Escherichia coli],1W7A_B ATP bound MutS [Escherichia coli],2WTU_A Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],2WTU_B Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],3ZLJ_A CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12],3ZLJ_B CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12]
7OTO_A	1.81e-06	730	805	34	110	ChainA, DNA mismatch repair protein MutS [Escherichia coli K-12],7OTO_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU4_A Chain A, DNA mismatch repair protein MutS [Escherichia coli],7OU4_B Chain B, DNA mismatch repair protein MutS [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q71TF8	3.73e-39	1138	2468	45	1567	Defense against restriction protein B OS=Escherichia phage P1 OX=2886926 GN=darB PE=3 SV=1
A9BJY3	4.42e-08	734	805	26	93	DNA mismatch repair protein MutS OS=Petrotoga mobilis (strain DSM 10674 / SJ95) OX=403833 GN=mutS PE=3 SV=1
A0L7L5	4.54e-08	730	805	24	100	DNA mismatch repair protein MutS OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) OX=156889 GN=mutS PE=3 SV=1
Q7WLT5	7.83e-08	730	805	27	103	DNA mismatch repair protein MutS OS=Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) OX=257310 GN=mutS PE=3 SV=2
Q7W880	7.85e-08	730	805	34	110	DNA mismatch repair protein MutS OS=Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) OX=257311 GN=mutS PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000062	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000892_01080.