dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000902_02664

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Basic Information help

Species

Clostridium neonatale

Lineage

Bacteria; Firmicutes_A; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium neonatale

CAZyme ID

MGYG000000902_02664

CAZy Family

GH126

CAZyme Description

Thiol-disulfide oxidoreductase ResA

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
548		63122.66	4.9474

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000902	4770522	MAG	China	Asia

Gene Location

Start: 34497; End: 36143 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000000902_02664.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH126	225	536	2.3e-84	0.9906542056074766

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd02966	TlpA_like_family	4.55e-25	89	201	8	116	TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.
pfam00578	AhpC-TSA	3.86e-15	86	195	11	121	AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).
cd03010	TlpA_like_DsbE	1.25e-13	93	203	18	121	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c maturation (Ccm) factor with a redox active CXXC motif. Assembly of cytochrome c requires the ligation of heme to reduced thiols of the apocytochrome. In bacteria, this assembly occurs in the periplasm. The reductase activity of DsbE in the oxidizing environment of the periplasm is crucial in the maturation of cytochrome c.
pfam13905	Thioredoxin_8	1.47e-13	101	195	1	94	Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.
PRK03147	PRK03147	6.74e-13	78	195	39	151	thiol-disulfide oxidoreductase ResA.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSX01740.1	4.21e-153	76	541	56	521
QUF82251.1	4.21e-153	76	541	56	521
QJU43754.1	4.21e-153	76	541	56	521
AXB84457.1	4.96e-153	76	541	61	526
QCJ05190.1	4.96e-153	76	541	61	526

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3REN_A	1.98e-39	247	541	55	350	CPF_2247,a novel alpha-amylase from Clostridium perfringens [Clostridium perfringens],3REN_B CPF_2247, a novel alpha-amylase from Clostridium perfringens [Clostridium perfringens]
4NMU_A	7.37e-15	82	202	17	132	CrystalStructure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' [Bacillus anthracis],4NMU_B Crystal Structure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' [Bacillus anthracis],4NMU_C Crystal Structure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' [Bacillus anthracis],4NMU_D Crystal Structure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' [Bacillus anthracis]
3ERW_A	3.48e-10	89	201	24	133	CrystalStructure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_B Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_C Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_D Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_E Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_F Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis],3ERW_G Crystal Structure of StoA from Bacillus subtilis [Bacillus subtilis]
3C73_A	5.78e-10	82	201	5	119	ChainA, Thiol-disulfide oxidoreductase resA [unidentified],3C73_B Chain B, Thiol-disulfide oxidoreductase resA [unidentified]
3KCM_A	1.06e-09	89	201	17	125	Thecrystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15],3KCM_B The crystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15],3KCM_C The crystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15],3KCM_D The crystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15],3KCM_E The crystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15],3KCM_F The crystal structure of thioredoxin protein from Geobacter metallireducens [Geobacter metallireducens GS-15]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O31486	2.63e-22	225	539	45	355	Putative lipoprotein YdaJ OS=Bacillus subtilis (strain 168) OX=224308 GN=ydaJ PE=3 SV=1
Q81FU5	2.16e-14	82	202	43	158	Thiol-disulfide oxidoreductase ResA OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) OX=226900 GN=resA PE=3 SV=1
A0RBT0	2.93e-14	82	202	43	158	Thiol-disulfide oxidoreductase ResA OS=Bacillus thuringiensis (strain Al Hakam) OX=412694 GN=resA PE=3 SV=1
Q81SZ9	2.93e-14	82	202	43	158	Thiol-disulfide oxidoreductase ResA OS=Bacillus anthracis OX=1392 GN=resA PE=1 SV=1
Q73B22	3.43e-13	82	215	43	167	Thiol-disulfide oxidoreductase ResA OS=Bacillus cereus (strain ATCC 10987 / NRS 248) OX=222523 GN=resA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.976624	0.008533	0.013840	0.000074	0.000038	0.000921

TMHMM Annotations download full data without filtering help

start	end
13	32