CAZyme Information: MGYG000000914_00752

Basic Information

• Species: Fusobacterium_A sp900015295
• Lineage: Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium_A; Fusobacterium_A sp900015295
• CAZyme ID: MGYG000000914_00752
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1C

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
750	MGYG000000914_12|CGC1	86539.62	9.8643

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000914	1959286	MAG	China	Asia

• Gene Location: Start: 16742; End: 18994 Strand: +

Full Sequence      

MKKIWIFLAFIVLIFISSISFIYCKFDIQNMKEDIENRYSQVVVDNRGKIIGAYLNQDEQ
WQVKGDGKIPSRLELAVLTFEDREFYNHNGINYLAILRAIKTNIFQKKRIGASTITMQVA
KLYKNRNRNYINKVLEIIEAKKIENNIGKEEILKLYLNNAPYGGNIIGYRTASLLYFKKE
PVNLTWAEGALLAILPNSPGMMNVEKNREILLKKRNTLLKTMYDTNIISQSQYKLSLNER
LPDKRYYFDLLAPHLTRRLKDEYSKEKIINSTIDSEIQKKVDKIVKNYSELIQNKGIKNA
AAIVIDNYNGEVKAYIGSQDFYDFEKNGQVDGIISFRSTGSVLKPFLYALSIDDGLIAPQ
SKLLDIPLYFSNFSPQNANKKYTGLVEAQEALKRSLNIPFVNLLNEYGQDRFFYFLKSVS
NFKDNDFSRYGLSLILGTKEMSIENIAQLYYGLANYGNFKNIKYIKNDLEEKNRQLITRG
AAYLTINDLSKVQRYGIQNLYTGRDNISWKTGTSYGQRDGWAAGISPKWTVVVWCGNFTG
EGNANISGIRTAGVLLFNIFKSLPKDNGIFIKPENDIKKIKIDNQTGYRIKYDVPTREID
YPKDAKPLKLSPYYKKIFINENGKLIDSRDKNFYKSTEKIIVSYPVELFNYLVKENMNIF
NISEKTIKFIYPLNGLKIKVPRDFDGKKKVIVKISNPNNYNIFWYLNGEYIGQGLDTERS
FSFLPGEQIISIIGENGETSQIKFEVTERK

Enzyme Prediction     

No EC number prediction in MGYG000000914_00752.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	50	223	6e-46	0.9774011299435028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4953	PbpC	0.0	2	746	1	731	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
TIGR02073	PBP_1c	0.0	38	746	9	726	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11240	PRK11240	2.54e-94	2	536	6	535	penicillin-binding protein 1C; Provisional
COG0744	MrcB	2.09e-92	4	595	19	633	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	5.68e-59	1	587	2	743	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QNM15576.1	0.0	1	750	1	750
AVQ18978.1	0.0	8	750	4	747
AVQ31509.1	0.0	1	750	1	754
VEH39720.1	0.0	1	750	1	754
SQJ06920.1	0.0	1	750	1	754

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5FGZ_A	2.25e-32	70	536	165	667	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	2.42e-32	70	536	186	688	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3UDF_A	4.83e-31	68	576	46	729	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3FWL_A	9.10e-31	70	536	169	671	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]
3DWK_A	1.61e-29	43	536	10	556	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	4.75e-72	40	556	42	557	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	6.27e-48	16	609	25	623	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P40750	3.04e-37	33	539	48	599	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
A7FY32	7.56e-36	26	561	53	641	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	7.56e-36	26	561	53	641	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.818221	0.103837	0.073793	0.000629	0.000370	0.003160

TMHMM  Annotations     

start	end
5	23