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CAZyme Information: MGYG000000963_01361
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | CAG-617 sp900553285 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; CAG-617; CAG-617 sp900553285 | |||||||||||
| CAZyme ID | MGYG000000963_01361 | |||||||||||
| CAZy Family | GH20 | |||||||||||
| CAZyme Description | Phosphoribosylaminoimidazole-succinocarboxamide synthase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 99; End: 1211 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH20 | 2 | 192 | 8.7e-52 | 0.5637982195845698 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK12607 | PRK12607 | 2.93e-119 | 190 | 370 | 134 | 313 | phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional |
| cd06563 | GH20_chitobiase-like | 1.03e-78 | 1 | 203 | 101 | 304 | The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. |
| pfam00728 | Glyco_hydro_20 | 2.83e-71 | 1 | 200 | 93 | 303 | Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold. |
| cd01414 | SAICAR_synt_Sc | 3.44e-65 | 190 | 345 | 131 | 279 | non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase. Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate. |
| PLN02544 | PLN02544 | 3.02e-57 | 190 | 364 | 197 | 370 | phosphoribosylaminoimidazole-succinocarboxamide synthase |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUT50216.1 | 7.87e-143 | 1 | 203 | 232 | 434 |
| QRP87681.1 | 9.34e-120 | 1 | 195 | 219 | 413 |
| CBW20983.1 | 9.34e-120 | 1 | 195 | 219 | 413 |
| ANQ62643.1 | 9.34e-120 | 1 | 195 | 219 | 413 |
| AKA50463.1 | 9.34e-120 | 1 | 195 | 219 | 413 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7CBN_A | 4.56e-38 | 2 | 172 | 232 | 409 | Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835] |
| 1OBG_A | 2.95e-25 | 174 | 345 | 134 | 300 | SAICAR-synthasecomplexed with ATP [Saccharomyces cerevisiae] |
| 1A48_A | 3.00e-25 | 174 | 345 | 135 | 301 | SaicarSynthase [Saccharomyces cerevisiae],1OBD_A SAICAR-synthase complexed with ATP [Saccharomyces cerevisiae],2CNQ_A Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate [Saccharomyces cerevisiae],2CNU_A Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with aspartic acid [Saccharomyces cerevisiae],2CNV_A SAICAR-synthase from Saccharomyces cerevisiae complexed SAICAR [Saccharomyces cerevisiae] |
| 6Q63_A | 3.23e-25 | 2 | 203 | 260 | 469 | BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron] |
| 6EZR_A | 9.35e-25 | 2 | 195 | 364 | 561 | Crystalstructure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi [Vibrio harveyi],6EZR_B Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi [Vibrio harveyi],6EZS_A Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi in complex with N-acetylglucosamine [Vibrio harveyi],6EZS_B Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi in complex with N-acetylglucosamine [Vibrio harveyi],6K35_A Crystal structure of GH20 exo beta-N-acetylglucosaminidase from Vibrio harveyi in complex with NAG-thiazoline [Vibrio harveyi],6K35_B Crystal structure of GH20 exo beta-N-acetylglucosaminidase from Vibrio harveyi in complex with NAG-thiazoline [Vibrio harveyi] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q64XV7 | 1.62e-105 | 190 | 370 | 134 | 314 | Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=purC PE=3 SV=1 |
| Q5LH03 | 1.62e-105 | 190 | 370 | 134 | 314 | Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) OX=272559 GN=purC PE=3 SV=1 |
| Q8A004 | 1.06e-103 | 190 | 370 | 134 | 314 | Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=purC PE=3 SV=1 |
| Q7MVR8 | 9.83e-80 | 190 | 369 | 135 | 313 | Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=purC PE=3 SV=1 |
| Q11TT6 | 1.28e-76 | 190 | 368 | 133 | 310 | Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) OX=269798 GN=purC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000052 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |