dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000001039_02064

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Basic Information help

Species

Phocaeicola sp900553185

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Phocaeicola; Phocaeicola sp900553185

CAZyme ID

MGYG000001039_02064

CAZy Family

GH33

CAZyme Description

Hercynine oxygenase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
643	MGYG000001039_145\|CGC1	71742.66	6.5947

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001039	3066315	MAG	Denmark	Europe

Gene Location

Start: 5506; End: 7437 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000001039_02064.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH33	288	587	3.3e-24	0.8333333333333334

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam03781	FGE-sulfatase	2.24e-52	29	250	4	258	Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.
COG1262	YfmG	8.40e-52	29	250	52	310	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones].
cd15482	Sialidase_non-viral	8.86e-39	273	587	1	304	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	1.19e-21	297	585	1	260	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
cd15482	Sialidase_non-viral	2.47e-04	370	451	212	306	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
ADV43483.1	25	639	24	642
SCV08950.1	24	640	22	663
ALJ49526.1	24	640	22	663
QRQ56304.1	24	640	22	663
QGT74043.1	24	640	22	663

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5HHA_A	2.79e-25	6	251	27	284	Structureof PvdO from Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1],5HHA_B Structure of PvdO from Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1]
2AFT_X	1.01e-21	29	248	5	279	ChainX, Sulfatase modifying factor 1 [Homo sapiens],2AIJ_X Chain X, Sulfatase modifying factor 1 [Homo sapiens],2AIK_X Chain X, Sulfatase modifying factor 1 [Homo sapiens],2HI8_X Chain X, Sulfatase-modifying factor 1 [Homo sapiens],2HIB_X Chain X, Sulfatase-modifying factor 1 [Homo sapiens]
2AFY_X	1.01e-21	29	248	5	279	ChainX, Sulfatase modifying factor 1 [Homo sapiens]
2AII_X	1.37e-21	29	248	5	279	wild-typeFormylglycine generating enzyme reacted with iodoacetamide [Homo sapiens]
1Y1F_X	2.11e-21	29	248	18	292	humanformylglycine generating enzyme with cysteine sulfenic acid [Homo sapiens],1Y1J_X human formylglycine generating enzyme, sulfonic acid/desulfurated form [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q8R0F3	3.22e-22	26	248	85	362	Formylglycine-generating enzyme OS=Mus musculus OX=10090 GN=Sumf1 PE=1 SV=2
Q7AJA5	8.28e-22	27	252	382	617	Serine/threonine-protein kinase pkn1 OS=Chlamydia pneumoniae OX=83558 GN=pkn1 PE=3 SV=1
Q9F3C7	2.21e-20	31	248	27	300	Formylglycine-generating enzyme OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) OX=100226 GN=SCO7548 PE=1 SV=1
Q8NBK3	2.82e-20	29	248	90	364	Formylglycine-generating enzyme OS=Homo sapiens OX=9606 GN=SUMF1 PE=1 SV=3
Q0P5L5	2.82e-20	3	248	72	364	Formylglycine-generating enzyme OS=Bos taurus OX=9913 GN=SUMF1 PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000820	0.987590	0.010795	0.000283	0.000255	0.000228

TMHMM Annotations download full data without filtering help

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