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CAZyme Information: MGYG000001091_02969
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Citrobacter_A sp009363175 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Citrobacter_A; Citrobacter_A sp009363175 | |||||||||||
| CAZyme ID | MGYG000001091_02969 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1607; End: 2809 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK00174 | PRK00174 | 0.0 | 1 | 397 | 242 | 637 | acetyl-CoA synthetase; Provisional |
| COG0365 | Acs | 0.0 | 1 | 379 | 168 | 528 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]. |
| cd05966 | ACS | 0.0 | 1 | 382 | 228 | 608 | Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme). Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation. |
| TIGR02188 | Ac_CoA_lig_AcsA | 0.0 | 1 | 392 | 234 | 626 | acetate--CoA ligase. This model describes acetate-CoA ligase (EC 6.2.1.1), also called acetyl-CoA synthetase and acetyl-activating enzyme. It catalyzes the reaction ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA and belongs to the family of AMP-binding enzymes described by pfam00501. |
| cd17634 | ACS-like | 0.0 | 1 | 359 | 229 | 587 | acetate-CoA ligase. This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 1.67e-183 | 1 | 390 | 821 | 1210 |
| CAE6201338.1 | 2.18e-183 | 1 | 390 | 832 | 1221 |
| BAY30132.1 | 1.35e-21 | 8 | 363 | 725 | 1079 |
| BAZ00088.1 | 2.43e-21 | 8 | 370 | 725 | 1090 |
| BAZ75991.1 | 2.43e-21 | 8 | 370 | 725 | 1090 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1PG3_A | 4.11e-301 | 1 | 400 | 253 | 652 | ChainA, acetyl-CoA synthetase [Salmonella enterica],1PG3_B Chain B, acetyl-CoA synthetase [Salmonella enterica],1PG4_A Chain A, acetyl-CoA synthetase [Salmonella enterica],1PG4_B Chain B, acetyl-CoA synthetase [Salmonella enterica] |
| 2P2M_A | 4.11e-301 | 1 | 400 | 253 | 652 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2F_A | 4.11e-301 | 1 | 400 | 253 | 652 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 5JRH_A | 5.49e-301 | 1 | 400 | 253 | 652 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
| 2P2B_A | 1.67e-300 | 1 | 400 | 253 | 652 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2B_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q8Z1R0 | 2.25e-300 | 1 | 400 | 253 | 652 | Acetyl-coenzyme A synthetase OS=Salmonella typhi OX=90370 GN=acs PE=3 SV=1 |
| Q8ZKF6 | 2.25e-300 | 1 | 400 | 253 | 652 | Acetyl-coenzyme A synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=acs PE=1 SV=1 |
| A8AN29 | 3.19e-300 | 1 | 400 | 253 | 652 | Acetyl-coenzyme A synthetase OS=Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) OX=290338 GN=acs PE=3 SV=1 |
| P27550 | 6.44e-300 | 1 | 400 | 253 | 652 | Acetyl-coenzyme A synthetase OS=Escherichia coli (strain K12) OX=83333 GN=acs PE=1 SV=2 |
| Q8FAY8 | 6.44e-300 | 1 | 400 | 253 | 652 | Acetyl-coenzyme A synthetase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=acs PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000058 | 0.000002 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |