dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000001173_00453

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Basic Information help

Species

Collinsella sp900759335

Lineage

Bacteria; Actinobacteriota; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Collinsella; Collinsella sp900759335

CAZyme ID

MGYG000001173_00453

CAZy Family

GH25

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1048		114648.83	6.2315

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001173	2216826	MAG	Austria	Europe

Gene Location

Start: 694; End: 3840 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000001173_00453.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH25	214	406	4.1e-42	0.9943502824858758
GH73	882	1027	2.1e-27	0.96875

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06414	GH25_LytC-like	1.98e-69	213	416	3	191	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a C-terminal glycosyl hydrolase family 25 (GH25) domain and an N-terminal choline-binding module (CBM) consisting of eleven homologous repeats that specifically recognizes the choline residues of pneumococcal lipoteichoic and teichoic acids. This domain arrangement is the reverse of the major pneumococcal autolysin, LytA, and the CPL-1-like lytic enzymes of the pneumococcal bacteriophages, in which the CBM (consisting of six repeats) is at the C-terminus. This model represents the C-terminal catalytic domain of the LytC-like enzymes.
COG4193	LytD	5.63e-52	794	1048	14	245	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].
cd00599	GH25_muramidase	1.77e-35	213	413	2	184	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.
NF033930	pneumo_PspA	1.36e-27	422	612	431	609	pneumococcal surface protein A. The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
cd06524	GH25_YegX-like	2.45e-25	213	413	2	190	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCA89043.1	0.0	1	1048	1	1048
BCS56855.1	0.0	1	1048	1	1072
AWY97591.1	7.22e-60	159	440	47	307
QOS67179.1	4.16e-56	831	1047	501	714
QCT06313.1	5.56e-52	158	448	36	310

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6FXO_A	2.60e-30	876	1048	86	244	ChainA, Bifunctional autolysin [Staphylococcus aureus subsp. aureus Mu50]
4PI7_A	5.90e-28	876	1028	78	212	ChainA, Autolysin E [Staphylococcus aureus subsp. aureus Mu50],4PI9_A Chain A, Autolysin E [Staphylococcus aureus subsp. aureus Mu50],4PIA_A Chain A, Autolysin E [Staphylococcus aureus subsp. aureus Mu50]
4PI8_A	3.72e-27	876	1028	78	212	ChainA, Autolysin E [Staphylococcus aureus subsp. aureus Mu50]
6FXP_A	9.54e-27	877	1028	96	230	ChainA, Uncharacterized protein [Staphylococcus aureus subsp. aureus Mu50],6FXP_B Chain B, Uncharacterized protein [Staphylococcus aureus subsp. aureus Mu50]
6U0O_B	2.49e-26	877	1028	126	260	ChainB, LYZ2 domain-containing protein [Staphylococcus aureus subsp. aureus NCTC 8325]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39848	2.82e-32	827	1048	686	880	Beta-N-acetylglucosaminidase OS=Bacillus subtilis (strain 168) OX=224308 GN=lytD PE=1 SV=1
Q5HH31	1.36e-26	876	1048	1098	1256	Bifunctional autolysin OS=Staphylococcus aureus (strain COL) OX=93062 GN=atl PE=3 SV=1
Q6GAG0	1.36e-26	876	1048	1092	1250	Bifunctional autolysin OS=Staphylococcus aureus (strain MSSA476) OX=282459 GN=atl PE=3 SV=1
Q6GI31	1.36e-26	876	1048	1099	1257	Bifunctional autolysin OS=Staphylococcus aureus (strain MRSA252) OX=282458 GN=atl PE=3 SV=1
A7X0T9	1.36e-26	876	1048	1097	1255	Bifunctional autolysin OS=Staphylococcus aureus (strain Mu3 / ATCC 700698) OX=418127 GN=atl PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.215806	0.759237	0.013374	0.008622	0.002251	0.000703

TMHMM Annotations download full data without filtering help

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20	42