You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000001239_01361
You are here: Home > Sequence: MGYG000001239_01361
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | CAG-776 sp900758895 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; RF39; UBA660; CAG-776; CAG-776 sp900758895 | |||||||||||
| CAZyme ID | MGYG000001239_01361 | |||||||||||
| CAZy Family | CBM50 | |||||||||||
| CAZyme Description | Cell division suppressor protein YneA | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 621; End: 1976 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CBM50 | 253 | 295 | 1.5e-17 | 0.975 |
| CBM50 | 358 | 400 | 7.7e-17 | 0.975 |
| CBM50 | 198 | 240 | 2.1e-16 | 0.975 |
| CBM50 | 409 | 451 | 3.9e-16 | 0.975 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK06347 | PRK06347 | 1.81e-41 | 198 | 399 | 333 | 591 | 1,4-beta-N-acetylmuramoylhydrolase. |
| PRK06347 | PRK06347 | 4.05e-39 | 247 | 450 | 327 | 591 | 1,4-beta-N-acetylmuramoylhydrolase. |
| cd02696 | MurNAc-LAA | 2.86e-31 | 4 | 180 | 1 | 172 | N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall. |
| PRK06347 | PRK06347 | 1.64e-28 | 297 | 448 | 325 | 521 | 1,4-beta-N-acetylmuramoylhydrolase. |
| COG0860 | AmiC | 1.73e-27 | 1 | 184 | 41 | 229 | N-acetylmuramoyl-L-alanine amidase [Cell wall/membrane/envelope biogenesis]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QVK20078.1 | 2.47e-65 | 5 | 297 | 2 | 286 |
| ARK32193.1 | 1.84e-55 | 190 | 451 | 380 | 654 |
| QZN88654.1 | 2.34e-55 | 195 | 448 | 349 | 659 |
| ASR40346.1 | 2.65e-55 | 198 | 446 | 527 | 832 |
| UAC47898.1 | 2.92e-55 | 198 | 451 | 119 | 412 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4B8V_A | 3.51e-15 | 198 | 342 | 44 | 212 | ChainA, Extracellular Protein 6 [Fulvia fulva],4B9H_A Chain A, Extracellular Protein 6 [Fulvia fulva] |
| 5J72_A | 4.87e-12 | 3 | 159 | 452 | 612 | ChainA, Putative N-acetylmuramoyl-L-alanine amidase,autolysin cwp6 [Clostridioides difficile 630],5J72_B Chain B, Putative N-acetylmuramoyl-L-alanine amidase,autolysin cwp6 [Clostridioides difficile 630] |
| 5EMI_A | 1.03e-11 | 5 | 183 | 7 | 178 | ChainA, Cell wall hydrolase/autolysin [Nostoc punctiforme PCC 73102] |
| 4RN7_A | 4.64e-10 | 2 | 183 | 3 | 182 | ChainA, N-acetylmuramoyl-L-alanine amidase [Clostridioides difficile 630] |
| 2MKX_A | 8.15e-08 | 253 | 298 | 7 | 52 | Solutionstructure of LysM the peptidoglycan binding domain of autolysin AtlA from Enterococcus faecalis [Enterococcus faecalis V583] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O07532 | 9.53e-45 | 193 | 450 | 24 | 350 | Peptidoglycan endopeptidase LytF OS=Bacillus subtilis (strain 168) OX=224308 GN=lytF PE=1 SV=2 |
| P37710 | 3.83e-44 | 90 | 448 | 358 | 734 | Autolysin OS=Enterococcus faecalis (strain ATCC 700802 / V583) OX=226185 GN=EF_0799 PE=1 SV=2 |
| O31852 | 5.69e-37 | 193 | 450 | 24 | 268 | D-gamma-glutamyl-meso-diaminopimelic acid endopeptidase CwlS OS=Bacillus subtilis (strain 168) OX=224308 GN=cwlS PE=1 SV=1 |
| P39046 | 1.72e-31 | 193 | 450 | 333 | 664 | Muramidase-2 OS=Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R) OX=768486 GN=EHR_05900 PE=1 SV=1 |
| P54421 | 2.38e-29 | 255 | 404 | 30 | 197 | Probable peptidoglycan endopeptidase LytE OS=Bacillus subtilis (strain 168) OX=224308 GN=lytE PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000043 | 0.000006 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |