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CAZyme Information: MGYG000001279_02659
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Pseudomonas_E fulva | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas_E; Pseudomonas_E fulva | |||||||||||
| CAZyme ID | MGYG000001279_02659 | |||||||||||
| CAZy Family | GH13 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 61; End: 2025 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| TIGR02457 | TreS_Cterm | 0.0 | 122 | 647 | 1 | 528 | trehalose synthase-fused probable maltokinase. Three pathways for the biosynthesis of trehalose, an osmoprotectant that in some species is also a precursor of certain cell wall glycolipids. Trehalose synthase, TreS, can interconvert maltose and trehalose, but while the equilibrium may favor trehalose, physiological concentrations of trehalose may be much greater than that of maltose and TreS may act largely in its degradation. This model describes a domain found only as a C-terminal fusion to TreS proteins. The most closely related proteins outside this family, Pep2 of Streptomyces coelicolor and Mak1 of Actinoplanes missouriensis, have known maltokinase activity. We suggest this domain acts as a maltokinase and helps drive conversion of trehalose to maltose. [Energy metabolism, Biosynthesis and degradation of polysaccharides] |
| COG3281 | Ble | 4.60e-104 | 199 | 643 | 26 | 425 | Predicted trehalose synthase [Carbohydrate transport and metabolism]. |
| PRK14705 | PRK14705 | 1.93e-37 | 139 | 651 | 1 | 474 | glycogen branching enzyme; Provisional |
| pfam16657 | Malt_amylase_C | 2.51e-30 | 21 | 103 | 1 | 75 | Maltogenic Amylase, C-terminal domain. This is the C-terminal domain of Maltogenic amylase, an enzyme that hydrolyzes starch material. Maltogenic amylases are central to carbohydrate metabolism. |
| pfam18085 | Mak_N_cap | 0.007 | 155 | 213 | 1 | 60 | Maltokinase N-terminal cap domain. Glycogen is a central energy storage molecule in bacteria and the metabolic pathways associated with its biosynthesis and degradation are crucial for maintaining cellular energy homeostasis. In mycobacteria, the GlgE pathway involves the combined action of trehalose synthase (TreS), maltokinase (Mak) and maltosyltransferase (GlgE). The N-terminal lobe can be divided into two subdomains: a cap N-terminal subdomain comprising the first 88 amino acid residues. This entry is for the cap N-terminal domain found in mycobacterial maltokinase (Mak), (EC:2.7.1.175). The N-terminal cap subdomain and the C-terminal lobe are predominantly acidic, the intermediate subdomain is enriched in positively charged residues. A structural search with only the first 88 amino acid residues of Mak, corresponding to the N-terminal cap subdomain of maltokinases, unveiled a resemblance with proteins displaying the cystatin fold and a remote similarity with the N-terminal domain of the serine/threonine protein kinase GCN2. Conservation of the cap subdomain in maltokinases (including the bifunctional TreS-Mak enzymes), in particular of the residues in the proximity of the P-loop, together with the potential flexibility of this region, are compatible with regulatory functions for this subdomain. Hence it is hypothesized that the N-terminal cap subdomain plays a central role in modulation of Mak enzymatic activity. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QPH42457.1 | 0.0 | 1 | 654 | 453 | 1106 |
| QPH47520.1 | 0.0 | 1 | 654 | 453 | 1106 |
| QDC04050.1 | 0.0 | 1 | 654 | 453 | 1106 |
| AVF56025.1 | 0.0 | 1 | 654 | 453 | 1106 |
| CRN07790.1 | 0.0 | 1 | 654 | 453 | 1106 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4O7O_A | 5.82e-46 | 143 | 649 | 2 | 455 | ChainA, Maltokinase [Mycobacterium tuberculosis],4O7O_B Chain B, Maltokinase [Mycobacterium tuberculosis],4O7P_A Chain A, Maltokinase [Mycobacterium tuberculosis],4O7P_B Chain B, Maltokinase [Mycobacterium tuberculosis] |
| 5JY7_I | 8.14e-42 | 149 | 647 | 2 | 440 | Complexof Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_J Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_K Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_L Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_M Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_N Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_O Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_P Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155] |
| 4U94_A | 5.63e-35 | 292 | 647 | 132 | 440 | Structureof mycobacterial maltokinase, the missing link in the essential GlgE-pathway [Mycolicibacterium vanbaalenii PYR-1],4U98_A Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (AppCp complex) [Mycolicibacterium vanbaalenii PYR-1],4WZY_A Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (ATP complex) [Mycolicibacterium vanbaalenii PYR-1] |
| 3ZO9_A | 4.95e-28 | 1 | 114 | 473 | 590 | ChainA, Trehalose Synthase/amylase Tres [Mycolicibacterium smegmatis],3ZO9_B Chain B, Trehalose Synthase/amylase Tres [Mycolicibacterium smegmatis],3ZOA_A Chain A, Trehalose Synthase/amylase Tres [Mycolicibacterium smegmatis],3ZOA_B Chain B, Trehalose Synthase/amylase Tres [Mycolicibacterium smegmatis],5JY7_A Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_B Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_C Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_D Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_E Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_F Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_G Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_H Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155] |
| 5X7U_A | 6.65e-28 | 1 | 113 | 441 | 548 | Trehalosesynthase from Thermobaculum terrenum [Thermobaculum terrenum ATCC BAA-798] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q7U2S7 | 2.48e-46 | 143 | 649 | 2 | 455 | Maltokinase OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) OX=233413 GN=mak PE=1 SV=1 |
| A5WII2 | 2.48e-46 | 143 | 649 | 2 | 455 | Maltokinase OS=Mycobacterium tuberculosis (strain F11) OX=336982 GN=mak PE=3 SV=1 |
| C1AJF3 | 2.48e-46 | 143 | 649 | 2 | 455 | Maltokinase OS=Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) OX=561275 GN=mak PE=3 SV=1 |
| C6DQZ2 | 2.48e-46 | 143 | 649 | 2 | 455 | Maltokinase OS=Mycobacterium tuberculosis (strain KZN 1435 / MDR) OX=478434 GN=mak PE=3 SV=1 |
| A1KEU8 | 2.48e-46 | 143 | 649 | 2 | 455 | Maltokinase OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) OX=410289 GN=mak PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000050 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |