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CAZyme Information: MGYG000001318_02670

You are here: Home > Sequence: MGYG000001318_02670

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Enterobacter cancerogenus
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Enterobacter; Enterobacter cancerogenus
CAZyme ID MGYG000001318_02670
CAZy Family GH18
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
912 MGYG000001318_10|CGC8 97505.96 4.5159
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001318 4633453 Isolate not provided not provided
Gene Location Start: 428938;  End: 431676  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 156 546 7.3e-74 0.9493243243243243

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 1.28e-126 159 543 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 1.34e-125 158 543 1 334
Glyco_18 domain.
COG3325 ChiA 1.13e-120 120 553 1 434
Chitinase, GH18 family [Carbohydrate transport and metabolism].
pfam00704 Glyco_hydro_18 9.91e-93 158 543 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 5.44e-65 162 553 4 360
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AUJ82266.1 0.0 1 912 1 912
CAD5354161.1 0.0 1 912 1 912
QGG08829.1 0.0 1 912 1 912
ANG92238.1 0.0 1 912 1 907
QCE24519.1 0.0 1 912 1 908

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1RD6_A 3.43e-257 2 561 3 561
ChainA, Chitinase A [Serratia marcescens],1X6L_A Chain A, Chitinase A [Serratia marcescens],1X6N_A Chain A, Chitinase A [Serratia marcescens]
1EDQ_A 1.71e-256 23 561 1 538
CrystalStructure Of Chitinase A From S. Marcescens At 1.55 Angstroms [Serratia marcescens],1FFQ_A Crystal Structure Of Chitinase A Complexed With Allosamidin [Serratia marcescens]
2WK2_A 1.71e-256 23 561 1 538
ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline dithioamide. [Serratia marcescens]
2WLY_A 2.28e-256 23 561 1 538
ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline. [Serratia marcescens],2WLZ_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline. [Serratia marcescens],2WM0_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline thioamide. [Serratia marcescens]
1CTN_A 3.42e-256 23 561 1 538
CRYSTALSTRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION [Serratia marcescens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P07254 4.67e-257 2 561 3 561
Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3
P32823 3.46e-211 23 861 21 820
Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
O10363 8.42e-209 23 553 16 542
Probable endochitinase OS=Orgyia pseudotsugata multicapsid polyhedrosis virus OX=262177 GN=ORF124 PE=3 SV=1
P41684 1.74e-208 23 552 17 542
Chitinase OS=Autographa californica nuclear polyhedrosis virus OX=46015 GN=CHIA PE=1 SV=1
P20533 5.15e-62 150 767 38 651
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000335 0.998847 0.000189 0.000215 0.000195 0.000182

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001318_02670.