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CAZyme Information: MGYG000001345_01080
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacteroides xylanisolvens | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides xylanisolvens | |||||||||||
| CAZyme ID | MGYG000001345_01080 | |||||||||||
| CAZy Family | GH99 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 139976; End: 141139 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH99 | 50 | 382 | 1.1e-126 | 0.9880239520958084 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam16317 | Glyco_hydro_99 | 0.0 | 44 | 384 | 2 | 342 | Glycosyl hydrolase family 99. This domain, around 350 residues, is mainly found in some uncharacterized proteins from bacteroides to human. Some proteins in this family, annotated as endo-alpha-mannosidases cleave mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. This domain reveals a (beta-alpha)(8) barrel fold in which the catalytic centre is present in a long substrate-binding groove, consistent with cleavage within the N-glycan chain, providing a foundation upon which to develop new enzyme inhibitors targeting the hijacking of N-glycan synthesis in viral disease and cancer. |
| cd11574 | GH99 | 4.31e-178 | 48 | 380 | 1 | 338 | Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase. This family of glycoside hydrolases 99 (following the CAZY nomenclature) includes endo-alpha-1,2-mannosidase (EC 3.2.1.130), which is an important membrane-associated eukaryotic enzyme involved in the maturation of N-linked glycans. Specifically, it cleaves mannoside linkages internal to N-linked glycan chains by hydrolyzing an alpha-1,2-mannosidic bond between a glucose-substituted mannose and the remainder of the chain. The biological function and significance of the soluble bacterial orthologs, which may have obtained the genes via horizontal transfer, is not clear. |
| cd11573 | GH99_GH71_like | 2.42e-105 | 105 | 380 | 5 | 284 | Glycoside hydrolase families 71, 99, and related domains. This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity. |
| cd11575 | GH99_GH71_like_3 | 3.10e-17 | 52 | 361 | 13 | 321 | Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism. |
| cd11578 | GH99_GH71_like_1 | 5.91e-15 | 100 | 361 | 23 | 302 | Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUT33051.1 | 4.34e-282 | 1 | 387 | 1 | 387 |
| QDH54618.1 | 4.34e-282 | 1 | 387 | 1 | 387 |
| QUR41867.1 | 1.24e-281 | 1 | 387 | 1 | 387 |
| QUT27489.1 | 2.51e-281 | 1 | 387 | 1 | 387 |
| CBK68409.1 | 1.77e-277 | 8 | 387 | 1 | 380 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4AD1_A | 6.47e-279 | 8 | 387 | 1 | 380 | Structureof the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens [Bacteroides xylanisolvens XB1A],4AD2_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD3_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD4_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine and alpha-1,2- mannobiose [Bacteroides xylanisolvens XB1A],4AD5_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-deoxymannojirimycin and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],4UTF_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine and alpha- 1,2-mannobiose [Bacteroides xylanisolvens XB1A],4V27_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine [Bacteroides xylanisolvens XB1A] |
| 4V28_A | 1.85e-278 | 8 | 387 | 1 | 380 | Structureof an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with Man-Man-Methylumbelliferone [Bacteroides xylanisolvens XB1A] |
| 5LYR_A | 3.26e-271 | 39 | 387 | 37 | 385 | Structureof the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-noeuromycin [Bacteroides xylanisolvens XB1A],5M03_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-noeuromycin and 1,2-alpha-mannobiose [Bacteroides xylanisolvens XB1A],5M17_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-1,2-dideoxymannose [Bacteroides xylanisolvens XB1A],5M3W_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-1,2-dideoxymannose and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],5M5D_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-D-glucal [Bacteroides xylanisolvens XB1A],5MC8_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-D-glucal and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6FAM_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-2-aminodeoxymannojirimycin [Bacteroides xylanisolvens XB1A],6FAR_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-mannoimidazole [Bacteroides xylanisolvens XB1A],6FWI_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-mannosamine) [Bacteroides xylanisolvens XB1A],6FWJ_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-mannosamine) and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6FWM_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-1,2-anhydro-mannose hydrolyzed by enzyme [Bacteroides xylanisolvens XB1A],6FWP_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-1,3-mannobiose and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6HMG_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-glucosamine) [Bacteroides xylanisolvens XB1A],6HMH_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-glucosamine) and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6ZJ6_AAA Chain AAA, Glycosyl hydrolase family 71 [Bacteroides xylanisolvens XB1A] |
| 5MEL_A | 9.35e-271 | 39 | 387 | 37 | 385 | Structureof an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with Glc-alpha-1,3-(3R,4R,5R)-5-(hydroxymethyl)cyclohex-1,2-ene-3,4-diol [Bacteroides xylanisolvens XB1A],6FWG_A Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with tetramannoside yeast mannan fragment [Bacteroides xylanisolvens XB1A],6FWL_A Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex alpha-Glc-1,3-(1,2-anhydro-carba-mannose) [Bacteroides xylanisolvens XB1A],6FWQ_A Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-1,3-mannobiose and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A] |
| 6FWO_A | 9.35e-271 | 39 | 387 | 37 | 385 | Structureof an E336Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-1,2-anhydro-mannose hydrolyzed by enzyme [Bacteroides xylanisolvens XB1A] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q5GF25 | 2.86e-101 | 44 | 386 | 99 | 450 | Glycoprotein endo-alpha-1,2-mannosidase OS=Rattus norvegicus OX=10116 GN=Manea PE=1 SV=1 |
| Q6NXH2 | 4.04e-101 | 44 | 386 | 99 | 450 | Glycoprotein endo-alpha-1,2-mannosidase OS=Mus musculus OX=10090 GN=Manea PE=2 SV=1 |
| Q5RD93 | 6.43e-100 | 51 | 386 | 106 | 450 | Glycoprotein endo-alpha-1,2-mannosidase OS=Pongo abelii OX=9601 GN=MANEA PE=2 SV=1 |
| Q5SRI9 | 1.28e-99 | 51 | 386 | 106 | 450 | Glycoprotein endo-alpha-1,2-mannosidase OS=Homo sapiens OX=9606 GN=MANEA PE=1 SV=1 |
| Q6DE40 | 1.25e-93 | 45 | 387 | 94 | 445 | Glycoprotein endo-alpha-1,2-mannosidase OS=Xenopus laevis OX=8355 GN=manea PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000418 | 0.289156 | 0.709992 | 0.000173 | 0.000141 | 0.000123 |