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CAZyme Information: MGYG000001345_04588
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacteroides xylanisolvens | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides xylanisolvens | |||||||||||
| CAZyme ID | MGYG000001345_04588 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1476968; End: 1479151 Strand: + | |||||||||||
Full Sequence Download help
| MKRKSVYTCL VMLFMSLVLQ AKDKDVAVAE ALLKRLLPSY IESFQFQKLK GEKDCFTIES | 60 |
| VKDKIVIGGN NANSMAMGLN HYLKYYCLTT VSWYADIAVE IPEELPMVDE KVVSEARVDT | 120 |
| RFFLNYCTYG YTMPWWQWKE WERFIDWMAL NGINMPLAIT GQEAVWYKVW SKMGMSDIEI | 180 |
| RSYFTGPPYL PWHRMANIDR WNGPLPMEWL EHQVSLQKKI LARERELNMK PVLPAFAGHV | 240 |
| PADLKRIYPE ADIQHLGKWA GFADAYRCNF LNPNDALFAK IQKLFLDEQK KLFGTDHIYG | 300 |
| LDPFNEVDPP SFEPEYLRKI ASDMYATLTA ADPKAQWMQM TWMFYFDKDK WTSERMKALL | 360 |
| TGVPQNKMIL LDYHCENVEL WKRTEHFHDQ PYIWCYLGNF GGNTTLTGNV KESGARLENA | 420 |
| LINGGGNLKG IGSTLEGLDV MQFPYEYILE KAWNLNVDDN KWIECLADRH VGCVSQPVRD | 480 |
| AWKRLFNDIY VQVPRTLGTL PGYRPALNKN SEKRTSNVYS NVELLEVWRK LNEAPSDRRD | 540 |
| AFRLDLITVG RQVLGNYFLD VKMEFDRMVE AKDHQALKAC GEKMKEILND LDKLNAFHPY | 600 |
| CSLDKWIDDA RKMGDSPQLK DYYEKNARNL ITTWGGSLND YASRSWAGLI SDYYAKRWEV | 660 |
| YVNTFIKAAE EGVEVDQKQL EDELKEIEEG WVNATDRKDT RKDVHSTTDG LLSFSTFLFS | 720 |
| KYQRLVK | 727 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 62 | 702 | 1.3e-234 | 0.975867269984917 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 0.0 | 121 | 454 | 1 | 332 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 5.00e-82 | 462 | 701 | 1 | 248 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 1.58e-28 | 29 | 106 | 3 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QGT72320.1 | 0.0 | 1 | 727 | 1 | 727 |
| QRQ58944.1 | 0.0 | 1 | 727 | 1 | 727 |
| QUT79512.1 | 0.0 | 1 | 727 | 1 | 727 |
| QDM10125.1 | 0.0 | 1 | 727 | 1 | 727 |
| SCV06896.1 | 0.0 | 1 | 727 | 1 | 727 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4XWH_A | 8.28e-125 | 64 | 697 | 51 | 691 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
| 2VC9_A | 1.07e-81 | 44 | 722 | 192 | 877 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 1.22e-81 | 44 | 722 | 200 | 885 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 1.07e-80 | 44 | 722 | 215 | 900 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P54802 | 3.93e-125 | 64 | 697 | 74 | 714 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| Q9FNA3 | 4.31e-123 | 29 | 668 | 49 | 754 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000231 | 0.999144 | 0.000181 | 0.000147 | 0.000137 | 0.000130 |