CAZyme Information: MGYG000001350_01931

Basic Information

• Species: Fusobacterium periodonticum_B
• Lineage: Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium; Fusobacterium periodonticum_B
• CAZyme ID: MGYG000001350_01931
• CAZy Family: GT2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
285	MGYG000001350_24|CGC4	33413.52	9.4878

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001350	2454675	Isolate	not provided	not provided

• Gene Location: Start: 810782; End: 811639 Strand: +

Full Sequence      

MKISVIVPVYNRLEHLRALFLCLLRQKKQADELIITDDGSSQKVLDFIGDLIPKAQFKVK
HIYQEDKGFRKTRALNNAVRNSTGDLLIFCDQDLIFGEEYIETIVNNIKSNIFLMGRAHH
TTEEQKNLILSDIENINSYNEIIKKLPAKYIETIDKMLKEDRKRRIIKTFKLAKRGIRLV
GMSYALMKEAYLKVNGYDENYIGWGQEDDDFGNRLTVAGINGRELITKNIQLHLWHYSDP
TKVHSSNEEYYYKRKKEIFSKKDFFCKKGYEDSKIRDDVTIKTLN

Enzyme Prediction     

No EC number prediction in MGYG000001350_01931.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	4	133	2.8e-23	0.7705882352941177

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06420	GT2_Chondriotin_Pol_N	2.90e-39	5	235	1	182	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase. Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.
pfam00535	Glycos_transf_2	7.79e-19	4	146	1	144	Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
cd00761	Glyco_tranf_GTA_type	3.16e-16	5	105	1	99	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
cd02525	Succinoglycan_BP_ExoA	4.08e-14	2	219	1	194	ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.
COG0463	WcaA	1.32e-12	1	237	3	231	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALQ40764.1	6.08e-192	1	285	1	285
QJX50190.1	2.03e-190	1	285	1	285
ASG27601.1	4.10e-190	1	285	1	285
QNE65635.1	5.82e-190	1	285	1	285
QYR58789.1	2.37e-189	1	285	1	285

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2Z86_A	1.89e-11	3	219	95	316	Crystalstructure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_B Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_C Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli],2Z86_D Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP [Escherichia coli]
2Z87_A	1.89e-11	3	219	94	315	Crystalstructure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP [Escherichia coli],2Z87_B Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP [Escherichia coli]
2FYD_B	4.21e-06	185	221	179	215	ChainB, beta-1,4-galactosyltransferase [Bos taurus],2FYD_D Chain D, beta-1,4-galactosyltransferase [Bos taurus]
1NF5_B	7.56e-06	185	221	179	215	CrystalStructure of Lactose Synthase, Complex with Glucose [Bos taurus],1NF5_D Crystal Structure of Lactose Synthase, Complex with Glucose [Bos taurus],1NKH_B Crystal structure of Lactose synthase complex with UDP and Manganese [Bos taurus],1NKH_D Crystal structure of Lactose synthase complex with UDP and Manganese [Bos taurus],1NQI_B crystal structure of lactose synthase, a 1:1 complex between beta1,4-galactosyltransferase and alpha-lactalbumin in the presence of GlcNAc [Bos taurus],1NQI_D crystal structure of lactose synthase, a 1:1 complex between beta1,4-galactosyltransferase and alpha-lactalbumin in the presence of GlcNAc [Bos taurus],1NWG_B Beta-1,4-Galactosyltransferase Complex With Alpha- Lactalbumin And N-Butanoyl-Glucoamine [Bos taurus],1NWG_D Beta-1,4-Galactosyltransferase Complex With Alpha- Lactalbumin And N-Butanoyl-Glucoamine [Bos taurus],1O23_B Crystal Structure Of Lactose Synthase In The Presence Of Udp-glucose [Bos taurus],1O23_D Crystal Structure Of Lactose Synthase In The Presence Of Udp-glucose [Bos taurus],1OQM_B A 1:1 complex between alpha-lactalbumin and beta1,4-galactosyltransferase in the presence of UDP-N-acetyl-galactosamine [Bos taurus],1OQM_D A 1:1 complex between alpha-lactalbumin and beta1,4-galactosyltransferase in the presence of UDP-N-acetyl-galactosamine [Bos taurus]
1NMM_B	7.56e-06	185	221	179	215	ChainB, BETA-1,4-GALACTOSYLTRANSFERASE [Bos taurus],1NMM_D Chain D, BETA-1,4-GALACTOSYLTRANSFERASE [Bos taurus],1O0R_A Chain A, beta-1,4-galactosyltransferase [Bos taurus],1O0R_B Chain B, beta-1,4-galactosyltransferase [Bos taurus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
H2K893	8.26e-11	3	220	11	229	Validoxylamine A glucosyltransferase OS=Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) OX=1133850 GN=valG PE=1 SV=1
Q8L0V4	1.08e-10	3	219	152	373	Chondroitin synthase OS=Escherichia coli OX=562 GN=kfoC PE=1 SV=1
Q15JF5	2.12e-10	3	220	42	260	Validoxylamine A glucosyltransferase OS=Streptomyces hygroscopicus subsp. limoneus OX=264445 GN=vldK PE=3 SV=1
Q9CMP0	2.22e-09	3	219	153	374	Chondroitin synthase OS=Pasteurella multocida (strain Pm70) OX=272843 GN=fcbD PE=3 SV=1
Q92IF9	6.39e-08	2	138	294	423	Uncharacterized glycosyltransferase RC0461 OS=Rickettsia conorii (strain ATCC VR-613 / Malish 7) OX=272944 GN=RC0461 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000055	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001350_01931.