CAZyme Information: MGYG000001371_02007

Basic Information

• Species: Paenibacillus lautus_A
• Lineage: Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus; Paenibacillus lautus_A
• CAZyme ID: MGYG000001371_02007
• CAZy Family: SLH
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2084	MGYG000001371_46|CGC3	222435.43	4.4625

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001371	6950059	Isolate	not provided	not provided

• Gene Location: Start: 74793; End: 81047 Strand: -

Full Sequence      

MRIRLHRCQRPLSMLLAIVMLLSIIVPFSPVKVAEASPRHDQVVISQVYGGGGNSGAVYT
HDFIELFNPTSSPVDLTGWKVRYASAAGNFNNETSLTGTIKPYAYYLIQQQSNGSVGGSL
PTADAAGALNLSGSNGKVDLVNAAGDRIDLIGYGNATLSEKSPTAALSNSTAAIRKELTV
GQNDRGRDTDNNVADFIVMTPDPRNSASPVTPVTPGSGLGVVTANPEPNAWPAGTEITLN
PPTVGASVYADVYLSSGNGSGFQIVNGPIILNEPTRVDAYAAQDGQPDGPVSSFQYDILR
QSSVADARSKAKGEHVWTEGIITHIEGRETYIQDDTAGIVLYDYPLNASVGDRVSVAGVM
EIYNNLQEIKPHALLPHDVTGNQVGVPQALPITGADLSAAAGENYEARLVSLNDVTIKSE
NRPGEYTAEQGGHEFIIYSGLSKLKTVKTFSRITGVVKQFGNVYELIPLGEDALIEEMFS
VIASPGAGPIITGGTVTLSSPTQGASIYYTLDGSVPTTASTLYSAPIQIDRDTTIKAIVV
SGADVSKVYEFAYKATQQPRIADIQGEDHASPYTGQTVTDIEGVVTQYGYTFSNGNIKGF
YIQDPKPDSNPDTSDAIFVYSTDPNRPQIGDLVSVIGKVAEYNEGSSSNLTSTQIEMQSF
KKLDQAQQLPEPVTLGKGGRPIPAAIIDNDGMTTFDPDEDAIDFYESLEGMLVRLPQPTI
ISPYWTSGGTYNIATRVENDVADVITPAGGLVLKENGNFNPQRLLIAYGNPGQEVSTGDT
FADDVIGVIGYNGGNFKVIPAKDSLPPIDSSSFKQEVSTIDVNAEQLRVATYNIENFYPG
VSSAKINKLAESIVNNIKSPDIIGLVEVQDNNGEQNNGTTAADQSYQTLINAIKAAGGPT
YSFTDIEPVNNNDGGAPGANIRVGFLYNADRVQLTDSVQGKKGSPTESVAYDAATDQLTL
NPGRIDPQNAAFNASRKPLAAQFEFQGEKVIVIANHFNSKSGDQGPFGNTQPPVLSSETQ
RHQIAAVVNGFVKDVVSANPDANVVVLGDLNDFQFTETTNILKGNELDNLIETLPLKEQY
TYTYDGNSQVLDHILVSKNLTRSTQVDIVHLNADFPASKGRVSDHDPVVAQIDLKEEAAN
GFPLTILHTNDTHANLDTVSSPDNIARRVTAIKEAKANAVNPLLVDAGDVFSGTLYFNQY
LGLADLEFMNLVQYDAMTFGNHEFDKGSEVLNDFIEHAEFPFVSSNVNFSADALLTQKFK
NEVTRDAKDATIYPAIIMEVDGEQVGLIGLTTEDTANIASPGDVTFENAVQKAKDTVAML
KNEGINKIVVLSHLGYDVDVNLAKEVEGIDIIVGGHSHTKLDQAVVDRSDSEPKLIVQTG
EKGQFLGQLEVVFDDEGVLQEWNSSLISVDEKGSNEQYVIQPDPEALQILNTKYKPGVEA
LKQTEVGTTEVKLNGVRADVRTKETNLGNLIADGMLDAAQAAGTNAVIALQNGGGIRESI
EAGKITMGDVMTVLPFNNDLVTITLTGAEIKEAMENGVSKTPAQDGRFPHIAGMKFYYDS
TKPVGSRVLRIEVKGKNGYEPIDMNKSYEVATNAFTAKGGDFYASLEKAYLEGRVNLLYK
PDYEVFSNYVKKVGTITTKTSAVEGRITDLKGAPLPGGPGEPGPGNPGNPGTPGTPGPTT
PPVNPSNPGTTTPAEPGKVKVPVMVENGAAAGSVTGAAMKEALKQPVGGKVTVEVTSTQP
ISSSSVTIENEALRAWLDQTSAKVLVVATPYGSYELPKKEIDLQALAAQAGSDMNSLQLV
IQLAIDEDALKSAASKGYHALQAVSYTVTVKSGNGKTITLDSFQTYVKRSLNVDKSHALT
DIAVVRVDGNGEYTPVPFKVNGQRIDIYSRTNSTYLVLQNPVTFQDIASHWSKGEVESLA
AKMIVTGRTEQTFVPNAPVTRAEFAALVVRALGLSADAASGSFQDVASSDWYAGAIQAAV
DADIINGYTDGTFKPNRTITREEMAAMAYNALEYAGYNPVDAAKAHFADASSIGAWSQVA
VYELAALDILNGDPKQRFNPKSNATRGESAAVLHRLMQDLTYVK

Enzyme Prediction     

No EC number prediction in MGYG000001371_02007.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
SLH	1963	2003	1.1e-16	0.9523809523809523

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK09419	PRK09419	6.91e-126	1144	1650	661	1146	multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase.
COG0737	UshA	1.06e-105	1137	1638	20	503	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms].
cd07409	MPP_CD73_N	3.08e-93	1144	1403	1	273	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain. CD73 is a mammalian ecto-5'-nucleotidase expressed in endothelial cells and lymphocytes that catalyzes the conversion of 5'-AMP to adenosine in the final step of a pathway that generates adenosine from ATP. This pathway also includes a CD39 nucleoside triphosphate dephosphorylase that mediates the dephosphorylation of ATP to ADP and then to 5'-AMP. These enzymes all have an N-terminal metallophosphatase domain and a C-terminal 5'nucleotidase domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
PRK09558	ushA	3.55e-92	1144	1636	35	537	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed
COG2374	COG2374	1.35e-78	561	1138	199	792	Predicted extracellular nuclease [General function prediction only].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CCH00931.1	2.79e-123	556	1131	334	923
ASS55757.1	3.15e-100	1142	1656	26	540
QSZ00291.1	3.24e-100	1142	1656	26	540
QIJ42120.1	3.24e-100	1142	1656	26	540
AUW44375.1	3.54e-100	1142	1656	26	540

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2Z1A_A	4.43e-110	1138	1647	24	528	Crystalstructure of 5'-nucleotidase precursor from Thermus thermophilus HB8 [Thermus thermophilus HB8]
7D0V_A	7.28e-70	1142	1647	3	522	ChainA, Snake venom 5'-nucleotidase [Naja atra],7D0V_B Chain B, Snake venom 5'-nucleotidase [Naja atra]
5H7W_A	1.30e-69	1142	1647	3	522	Crystalstructure of 5'-nucleotidase from venom of Naja atra [Naja atra],5H7W_B Crystal structure of 5'-nucleotidase from venom of Naja atra [Naja atra]
4H1Y_P	9.03e-69	1144	1647	26	543	Humanecto-5'-nucleotidase (CD73): crystal form II (open) in complex with PSB11552 [Homo sapiens],6TVE_P Unliganded human CD73 (5'-nucleotidase) in the open state [Homo sapiens],6TVG_A Human CD73 (ecto 5'-nucleotidase) in complex with AMPCP in the open state [Homo sapiens],7BBJ_A Chain A, 5'-nucleotidase [Homo sapiens],7BBJ_B Chain B, 5'-nucleotidase [Homo sapiens],7P9N_A Chain A, 5'-nucleotidase [Homo sapiens],7P9R_A Chain A, 5'-nucleotidase [Homo sapiens],7P9T_A Chain A, 5'-nucleotidase [Homo sapiens],7PA4_A Chain A, 5'-nucleotidase [Homo sapiens],7PB5_A Chain A, 5'-nucleotidase [Homo sapiens],7PBA_A Chain A, 5'-nucleotidase [Homo sapiens],7PBB_A Chain A, 5'-nucleotidase [Homo sapiens],7PBY_A Chain A, 5'-nucleotidase [Homo sapiens],7PCP_A Chain A, 5'-nucleotidase [Homo sapiens],7PD9_A Chain A, 5'-nucleotidase [Homo sapiens]
4H2B_A	9.25e-69	1144	1647	27	544	Humanecto-5'-nucleotidase (CD73): crystal form II (open) in complex with Baicalin [Homo sapiens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O34313	9.14e-113	1144	1650	669	1177	Trifunctional nucleotide phosphoesterase protein YfkN OS=Bacillus subtilis (strain 168) OX=224308 GN=yfkN PE=1 SV=1
P29240	2.28e-73	1142	1647	30	546	5'-nucleotidase OS=Diplobatis ommata OX=1870830 PE=2 SV=1
F8S0Z7	1.27e-70	1138	1647	38	561	Snake venom 5'-nucleotidase OS=Crotalus adamanteus OX=8729 PE=1 SV=2
B6EWW8	1.43e-69	1138	1647	38	561	Snake venom 5'-nucleotidase OS=Gloydius brevicaudus OX=259325 PE=2 SV=1
A0A2I4HXH5	7.14e-69	1142	1647	3	522	Snake venom 5'-nucleotidase (Fragment) OS=Naja atra OX=8656 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000323	0.998977	0.000175	0.000184	0.000156	0.000140

TMHMM  Annotations     

start	end
12	31