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CAZyme Information: MGYG000001380_02363

You are here: Home > Sequence: MGYG000001380_02363

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Ruminococcus_B gnavus
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Ruminococcus_B; Ruminococcus_B gnavus
CAZyme ID MGYG000001380_02363
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
743 MGYG000001380_8|CGC1 85169.17 5.3007
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001380 3437962 Isolate not provided not provided
Gene Location Start: 66798;  End: 69029  Strand: -

Full Sequence      Download help

MSICYHEGSR  EFHLSNRDIS  YIITVLKNGQ  LGQLYFGKKL  HDRESFAHLL  ELRHRPMAVC60
TYEGDSTFSM  EHIKQEYPSY  GAGDMRYPAV  EILQENGSRI  TDFVYQTHRI  YDGKPALAGL120
PATYTEDSKE  AQTLEIELKD  ELIHTTLILY  YTIFEELPAI  TRSAKVIYHG  TEKIVLERAM180
SCSVDLPDHD  YQMIELTGAW  GRERAVTERK  LQYGIQGIYS  MRGCSSSNFN  PFLALRRENT240
TEACGEVYGF  SLVYSGNFLA  QAEVDTYDVT  RVTLGIHPDR  FSWEMKNGDE  FQTPEAVMVY300
SNRGLNGMSQ  AFHSLYRARL  ARGYWRDRPR  PILINNWEAT  YFDFNEEKIL  EIVRTAKQLG360
IELFVLDDGW  FGKREDDHSS  LGDWYPNLEK  LPDGIAGIAK  KVAAEGMKFG  LWFEPEMVNK420
DSNLYREHPD  WILSTPGRHI  SHGRNQYILD  FSRAEVVDAI  YGQMEKILED  APISYIKWDM480
NRCMSEVYSH  TASAADQGKV  MHQYILGVYR  LYEKLTGRFP  EILFESCASG  GSRFDPGLLY540
YAPQAWTSDD  TDAVERCKIQ  YGTSLVYPVS  SMGSHVSAVP  NHQVLRNTSL  KMRADVAYFG600
TFGYELNPNS  LTEAEREAIK  KQTAFMKEHR  SLIQYGTFYR  LQSPFAGNEM  AWMVVSEDKK660
EAIVGWYRFL  EPINIGYRSV  RLQGLDPKLP  YQISDMEMAL  YGDELMQAGL  IVSDVASGQN720
PEQYNGENGD  FQSRLYLLKA  KEE743

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap377411114818522226029733437140844548252055759463166870512711GH36
Family Start End Evalue family coverage
GH36 12 711 7e-289 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap377411114818522226029733437140844548252055759463166870511739GalA291636Melibiase329628GH3629286Glyco_hydro_36N649738Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 11 739 3 685
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 291 636 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 5.00e-145 329 628 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 1.51e-123 29 286 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 4.22e-25 649 738 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap37741111481852222602973343714084454825205575946316687051743QRT31098.1|GH361743QEI32555.1|GH361743QHB25044.1|GH361743ACL13770.1|GH36|3.2.1.221743BCD35358.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QRT31098.1 0.0 1 743 1 743
QEI32555.1 0.0 1 743 1 743
QHB25044.1 0.0 1 743 1 743
ACL13770.1 0.0 1 743 1 743
BCD35358.1 0.0 1 743 1 743

PDB Hits      download full data without filtering help

Created with Snap377411114818522226029733437140844548252055759463166870517404FNQ_A17404FNR_A17404FNU_A17404FNT_A17404FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 2.51e-282 1 740 1 726
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 9.47e-280 1 740 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 8.84e-278 1 740 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 1.25e-277 1 740 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 1.78e-277 1 740 1 726
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap37741111481852222602973343714084454825205575946316687051740sp|Q9ALJ4|AGAA_GEOSE3740sp|P43467|AGAL1_PEDPE3740sp|G1UB44|MELA_LACAC1710sp|G4T4R7|AGASK_RUMGN5710sp|Q0CEF5|AGALG_ASPTN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 5.19e-279 1 740 1 726
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
P43467 3.91e-223 3 740 4 729
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G1UB44 1.58e-219 3 740 6 730
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
G4T4R7 2.63e-196 1 710 1 701
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q0CEF5 2.19e-178 5 710 12 707
Probable alpha-galactosidase G OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=aglG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000057 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001380_02363.