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CAZyme Information: MGYG000001380_02364

You are here: Home > Sequence: MGYG000001380_02364

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Ruminococcus_B gnavus
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Ruminococcus_B; Ruminococcus_B gnavus
CAZyme ID MGYG000001380_02364
CAZy Family GH36
CAZyme Description Bifunctional alpha-galactosidase/sucrose kinase AgaSK
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
728 MGYG000001380_8|CGC1 82078.71 4.893
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001380 3437962 Isolate not provided not provided
Gene Location Start: 69127;  End: 71313  Strand: -

Full Sequence      Download help

MAIIFDEQNK  TFTIHTEHST  YQMQIDPYGV  LLHLYYGRKT  KGCMDYLLQK  QDRGFSGNLY60
DAGNDRTYSL  DVLPQEFPTW  GTGDYRSTAL  IVRGQDGTTA  CDLRYRGYRI  LSGKYGLSGL120
PAVYGAEKEA  QTLEVVLEDG  RTGIQVTLLY  GVLPKYDVIT  RSAQIINTKE  NIIYLEKAAS180
ACLDFVTGKY  DVISFYGRHA  MERNYQRIPV  SHGNYVIGSR  RGTSSHQYSP  FLILTEEGTT240
EDAGACYAMS  FVYSGGFQAE  VEKDQFGQNR  MLMGLQPEQF  SYPLNTGEVF  VIPETVMTYS300
RNGLAELSQN  LHRCFRNNLC  RGPHKEKVRP  ILINSWEASY  FDFDGESILK  LAEEAKELGI360
EMLVLDDGWF  GKRRDDNRAL  GDWQVNEEKL  KCSLGELSAK  IHAMGLKFGL  WVEPEMVSED420
SDLYRAHPDW  ALQIPGKNPV  RSRNQLVLDF  SRKDAVDFIF  DSITEVLDYA  EVEYLKWDMN480
RSLCDVYSAA  AGYQGKVLYD  YVLGVYDFLD  RLLKRYPNLL  IEGCSGGGGR  FDAGMLYYTP540
QIWCSDNTDA  LDRLQIQYGT  SFGFPISAVG  SHVSAVPNHQ  TGRKTPLSTR  GAVAMAGTFG600
YELDLGNVTE  EEKEEIRQQI  KEYKQLAPLI  QTGLYYRLSN  PVTDEVAAWE  FVSEDGTQAM660
MQAVMTQIHG  NMTGNAVKWK  GLEEEACYQD  AESGELYYGA  ALMETGILLP  IKNGAYQTFR720
ILLRKVGS728

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367210914518221825429132736440043647350954658261865569112707GH36
Family Start End Evalue family coverage
GH36 12 707 2.9e-264 0.9941860465116279

CDD Domains      download full data without filtering help

Created with Snap36721091451822182542913273644004364735095465826186556919726GalA290633Melibiase329625GH3629285Glyco_hydro_36N646723Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 9 726 1 687
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 290 633 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 1.00e-147 329 625 2 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 7.80e-116 29 285 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 1.23e-17 646 723 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36721091451822182542913273644004364735095465826186556911728QRT31097.1|GH361728QEI32554.1|GH361728QHB25043.1|GH361726QRT49300.1|GH361726QEK18307.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QRT31097.1 0.0 1 728 1 728
QEI32554.1 0.0 1 728 1 728
QHB25043.1 0.0 1 728 1 728
QRT49300.1 0.0 1 726 1 726
QEK18307.1 0.0 1 726 1 726

PDB Hits      download full data without filtering help

Created with Snap367210914518221825429132736440043647350954658261865569117202YFN_A17264FNQ_A17264FNR_A17264FNU_A17264FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2YFN_A 0.0 1 720 1 714
galactosidasedomain of alpha-galactosidase-sucrose kinase, AgaSK [[Ruminococcus] gnavus E1],2YFO_A GALACTOSIDASE DOMAIN OF ALPHA-GALACTOSIDASE-SUCROSE KINASE, AGASK, in complex with galactose [[Ruminococcus] gnavus E1]
4FNQ_A 1.62e-225 1 726 1 727
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 1.85e-224 1 726 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 1.70e-222 1 726 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNP_A 1.70e-222 1 726 1 727
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36721091451822182542913273644004364735095465826186556911720sp|G4T4R7|AGASK_RUMGN1726sp|Q9ALJ4|AGAA_GEOSE3717sp|G1UB44|MELA_LACAC3718sp|P43467|AGAL1_PEDPE8716sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
G4T4R7 0.0 1 720 1 714
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q9ALJ4 1.01e-223 1 726 1 727
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 1.45e-221 3 717 6 722
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 6.30e-218 3 718 4 722
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
P27756 1.30e-174 8 716 6 710
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000084 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001380_02364.