dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000001393_02505

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Basic Information help

Species

Hafnia paralvei

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Hafnia; Hafnia paralvei

CAZyme ID

MGYG000001393_02505

CAZy Family

GH23

CAZyme Description

Membrane-bound lytic murein transglycosylase F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
475	MGYG000001393_49\|CGC1	53660.18	9.9969

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001393	4880992	Isolate	not provided	not provided

Gene Location

Start: 187451; End: 188878 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000001393_02505.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH23	318	457	4.4e-22	0.8222222222222222

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd13403	MLTF-like	1.11e-73	309	456	1	159	membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
COG4623	MltF	4.27e-73	36	470	14	446	Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
PRK10859	PRK10859	4.25e-63	1	472	2	466	membrane-bound lytic murein transglycosylase MltF.
cd01009	PBP2_YfhD_N	3.89e-59	45	284	1	222	The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
pfam00497	SBP_bac_3	6.27e-27	57	263	12	203	Bacterial extracellular solute-binding proteins, family 3.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QQE45103.1	0.0	1	475	1	475
AJQ99495.1	0.0	1	475	1	475
AVE16696.1	0.0	1	474	1	474
QBJ33216.1	1.66e-286	1	474	1	475
AWV44845.1	3.34e-286	1	474	1	475

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5TUJ_C	2.68e-14	36	258	3	209	AncestralCationic Amino Acid Solute Binding Protein (AncCDT-1) [unidentified]
5T0W_A	3.23e-14	36	258	14	220	Crystalstructure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_B Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_C Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_D Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct]
2Y7I_A	2.79e-10	77	264	31	217	ChainA, Stm4351 [Salmonella enterica subsp. enterica serovar Typhimurium],2Y7I_B Chain B, Stm4351 [Salmonella enterica subsp. enterica serovar Typhimurium]
6GGP_A	3.99e-10	57	249	22	194	Structureof the ligand-free form of truncated ArgBP (residues 20-233) from T. maritima [Thermotoga maritima MSB8]
6GGV_A	4.05e-10	57	249	22	194	Structureof the arginine-bound form of truncated (residues 20-233) ArgBP from T. maritima [Thermotoga maritima MSB8],6GGV_B Structure of the arginine-bound form of truncated (residues 20-233) ArgBP from T. maritima [Thermotoga maritima MSB8]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A8ZWR8	1.43e-39	32	453	29	445	Membrane-bound lytic murein transglycosylase F OS=Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3) OX=96561 GN=mltF PE=3 SV=2
Q4KHS7	1.33e-35	36	475	32	470	Membrane-bound lytic murein transglycosylase F OS=Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) OX=220664 GN=mltF PE=3 SV=2
A4XXV1	2.61e-32	47	475	45	472	Membrane-bound lytic murein transglycosylase F OS=Pseudomonas mendocina (strain ymp) OX=399739 GN=mltF PE=3 SV=1
Q9KTN5	5.58e-32	36	453	33	458	Membrane-bound lytic murein transglycosylase F OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mltF PE=3 SV=1
A5F353	5.58e-32	36	453	33	458	Membrane-bound lytic murein transglycosylase F OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) OX=345073 GN=mltF PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000208	0.999194	0.000163	0.000148	0.000139	0.000130

TMHMM Annotations help

There is no transmembrane helices in MGYG000001393_02505.