CAZyme Information: MGYG000001422_03265

Basic Information

• Species: Bacteroides oleiciplenus
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides oleiciplenus
• CAZyme ID: MGYG000001422_03265
• CAZy Family: GH18
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
569	MGYG000001422_3|CGC11	64003.59	5.8811

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001422	7071122	Isolate	not provided	Asia

• Gene Location: Start: 647166; End: 648875 Strand: +

Full Sequence      

MILSVLAVLLSCSSKAGELRMASSDAKVIVAYVTSWSSVMPDPQYMTHINYAFGHVSETF
NGVGIANENRLREIVALKAQKPGLKIMLSIGGWGSGRFSEMAANDEFRLAFAKDCKRVVK
EYGLDGIDIDWEYPTSAAANISASPDDTKNFTLLMRDIRKEIGKKKLLTLATVASGEYID
FKAILPYIDFVNIMSYDMGNAPKHHAALYSSENTGWMTADGAVEAHLKAGVPASKLTMGV
PFYGRGGDQYPNFQDYHKVGGTAEFEERWDDTAKVPYLANKDGVLVFGYENPRSLAIKCQ
YILDKGLLGGMYWDYAGDNPQGDLRRTMYESLLVNKKGQPAPYQVLVLTERGGQHGGFTD
AGLQWLAQESGAMNFEITEINNAKPITEEYLNRFHLIIQLDYPPYTWSEAAQAAFTKYID
EGRGGWIGFHHATLLGEFDGYPMWQWFSDFMGGVRFKNYIAPLADGVVITEDTEHPVMKG
VQETFIIPDDEWYTYDKSPRRNVHVLAHVDEYSYTPASDVKMGDHPVVWVNENKKARNVY
FQIGHSKKLYETEDFTKMFRNAIQWTLKK

Enzyme Prediction     

No EC number prediction in MGYG000001422_03265.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH18	27	325	1.7e-73	0.9594594594594594

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06548	GH18_chitinase	2.60e-104	29	318	1	322	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636	Glyco_18	6.82e-80	28	318	1	334	Glyco_18 domain.
pfam00704	Glyco_hydro_18	1.95e-78	28	318	1	307	Glycosyl hydrolases family 18.
cd02872	GH18_chitolectin_chitotriosidase	6.12e-69	29	317	1	345	This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.
pfam06283	ThuA	1.72e-62	345	566	2	213	Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QDO71383.1	0.0	1	569	7	576
QQA31016.1	0.0	1	569	7	574
QUT62465.1	0.0	4	569	3	567
QUT64703.1	0.0	1	569	7	574
QUU00240.1	0.0	1	569	7	574

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6INX_A	3.74e-54	46	332	27	342	Structuralinsights into a novel glycoside hydrolase family 18 N-acetylglucosaminidase from Paenibacillus barengoltzii [Paenibacillus barengoltzii]
6TSB_AAA	6.74e-53	25	328	33	346	ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
6T9M_AAA	1.08e-52	25	328	52	365	ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
6HM1_A	2.94e-52	42	335	27	396	Structuraland thermodynamic signatures of ligand binding to an enigmatic chitinase-D from Serratia proteamaculans [Serratia proteamaculans 568]
4PTM_A	3.15e-52	42	335	30	399	CrystalStructure of Chitinase D from Serratia proteamaculans in complex with N-acetyl glucosamine, a hydrolyzed product of hexasaccharide at 1.7 Angstrom resolution [Serratia proteamaculans 568]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P20533	1.44e-43	23	318	40	438	Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
P11797	3.11e-35	32	324	21	414	Chitinase B OS=Serratia marcescens OX=615 GN=chiB PE=1 SV=1
P36362	4.28e-33	24	322	19	379	Endochitinase OS=Manduca sexta OX=7130 PE=2 SV=1
P36222	2.31e-32	25	324	20	363	Chitinase-3-like protein 1 OS=Homo sapiens OX=9606 GN=CHI3L1 PE=1 SV=2
Q13231	4.52e-32	25	317	20	367	Chitotriosidase-1 OS=Homo sapiens OX=9606 GN=CHIT1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000639	0.462353	0.536478	0.000172	0.000184	0.000175

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001422_03265.