CAZyme Information: MGYG000001433_01251

Basic Information

• Species: Bacteroides salyersiae
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides salyersiae
• CAZyme ID: MGYG000001433_01251
• CAZy Family: GH84
• CAZyme Description: O-GlcNAcase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
857		97887.15	6.3293

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001433	5309986	Isolate	not provided	not provided

• Gene Location: Start: 1581726; End: 1584299 Strand: +

Full Sequence      

MKMVNHKNTLYAGIACILMCGNLSAQETNFDLSSQRSEKQDVLAVPGEKVDHRGIIINPT
PQKLVFNGNSKLNISQGFILKDKQKKFTKDLEFVTLNKKGIKLSIDFGKKVAATQNVKEV
SGAYALTISSKGISIIGYDERGAFYGIQTLRQLAESPATVNGQLPYLEINDYPDLPNRGV
VEGFYGTPWSHEVRMSLIDFYGKFKMNTYLYGPKDDPYHSCPNWRLPYPEKEAKNIRQLI
EACNRNRVDFVWAIHPGQDIKWNEEDYNNLINKFNGMYDLGVRHFAIFFDDISGEGTNPL
KQTELLNRLTDDFVKVKGDITPLTVCPTDYSKLWANPTPEGSLAIYGKTLYPEIKVFWTG
DVVCSDLTKETLEFVNSRIKRPAYFWWNYPVTDYVRNILLQGPVYGLNTSLTEKDVCGVI
SNPMEHGEASKLALYGVADYTWNMAAYNAIDNWERGLSELIPQAREDYRRFAIHSSDTET
GYRRDESWETKTFRLTDWTEETAQALEEEFKKIENVPANLEKGCTNKKLLKELRPWLTEF
GKLGTRGKRAIELARIYRSNQDDALFWSKFVQNLMTKEERKNYDAHKSGTMKLQPFYENT
MDDMAHGFLKKLSGEIPMDYKGIGSFANSGTIQTKLMLDRDTTTYYTSGMAQKAGDWIGV
DLRTIRDVSEISILQGRNSVDDVDYFDHAILECSEDGKTWKPLTEELKQQYIIQWQGGAV
KARYVRLRRLDSKRTNYASIRSFEVNPLRIEDLRFKLQTENPEQALYAFDKNLGTSFKSK
DQDCLEFEVAKGTKAYTLLMNELPMPLKCKQFDVKGKLVSETSIDSPYAKIELSGKDVAK
VSIEGAAEIFEIIAESE

Enzyme Prediction     

No EC number prediction in MGYG000001433_01251.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH84	178	472	1.3e-105	0.9932203389830508

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam07555	NAGidase	6.44e-166	178	471	1	293	beta-N-acetylglucosaminidase. This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.
pfam02838	Glyco_hydro_20b	7.30e-14	59	171	6	123	Glycosyl hydrolase family 20, domain 2. This domain has a zincin-like fold.
pfam00754	F5_F8_type_C	7.57e-07	638	741	18	124	F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.
cd00057	FA58C	3.33e-05	657	745	47	141	Substituted updates: Jan 31, 2002
COG3525	Chb	3.52e-05	121	232	205	316	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALB75783.1	0.0	1	854	1	851
BCI62100.1	0.0	1	853	1	852
ADV43394.1	0.0	4	854	1	848
QUT73710.1	0.0	251	857	1	607
AHF11939.1	0.0	3	853	1	852

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2J47_A	1.04e-154	53	710	1	676	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor [Bacteroides thetaiotaomicron VPI-5482],2W4X_A BtGH84 in complex with STZ [Bacteroides thetaiotaomicron VPI-5482],2W66_A BtGH84 in complex with HQ602 [Bacteroides thetaiotaomicron VPI-5482],2W66_B BtGH84 in complex with HQ602 [Bacteroides thetaiotaomicron VPI-5482],2W67_A BtGH84 in complex with FMA34 [Bacteroides thetaiotaomicron VPI-5482],2W67_B BtGH84 in complex with FMA34 [Bacteroides thetaiotaomicron VPI-5482],2WCA_A BtGH84 in complex with n-butyl pugnac [Bacteroides thetaiotaomicron VPI-5482],2XJ7_A BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine [Bacteroides thetaiotaomicron VPI-5482],2XJ7_B BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine [Bacteroides thetaiotaomicron VPI-5482],2XM1_A BtGH84 in complex with N-acetyl gluconolactam [Bacteroides thetaiotaomicron VPI-5482],2XM1_B BtGH84 in complex with N-acetyl gluconolactam [Bacteroides thetaiotaomicron VPI-5482],2XM2_A BtGH84 in complex with LOGNAc [Bacteroides thetaiotaomicron VPI-5482],2XM2_B BtGH84 in complex with LOGNAc [Bacteroides thetaiotaomicron VPI-5482],4UR9_A Structure of ligand bound glycosylhydrolase [Bacteroides thetaiotaomicron],4UR9_B Structure of ligand bound glycosylhydrolase [Bacteroides thetaiotaomicron],5FKY_A Structure of a hydrolase bound with an inhibitor [Bacteroides thetaiotaomicron],5FKY_B Structure of a hydrolase bound with an inhibitor [Bacteroides thetaiotaomicron],5FL0_A Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL0_B Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL1_A Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron],5FL1_B Structure of a hydrolase with an inhibitor [Bacteroides thetaiotaomicron]
7K41_A	1.14e-154	53	710	4	679	ChainA, O-GlcNAcase BT_4395 [Escherichia coli K-12]
2VVN_A	1.39e-154	8	710	4	697	BtGH84in complex with NH-Butylthiazoline [Bacteroides thetaiotaomicron VPI-5482],2VVN_B BtGH84 in complex with NH-Butylthiazoline [Bacteroides thetaiotaomicron VPI-5482],2VVS_A BtGH84 structure in complex with PUGNAc [Bacteroides thetaiotaomicron VPI-5482],2X0H_A BtGH84 Michaelis complex [Bacteroides thetaiotaomicron VPI-5482],2X0H_B BtGH84 Michaelis complex [Bacteroides thetaiotaomicron VPI-5482],4AIS_A A complex structure of BtGH84 [Bacteroides thetaiotaomicron VPI-5482],4AIS_B A complex structure of BtGH84 [Bacteroides thetaiotaomicron VPI-5482],7OU8_AAA Chain AAA, O-GlcNAcase BT_4395 [Bacteroides thetaiotaomicron VPI-5482],7OU8_BBB Chain BBB, O-GlcNAcase BT_4395 [Bacteroides thetaiotaomicron VPI-5482]
2J4G_A	1.43e-154	55	710	2	675	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor [Bacteroides thetaiotaomicron VPI-5482],2J4G_B Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor [Bacteroides thetaiotaomicron VPI-5482]
2JIW_A	1.47e-154	55	710	3	676	Bacteroidesthetaiotaomicron GH84 O-GlcNAcase in complex with 2- Acetylamino-2-deoxy-1-epivalienamine [Bacteroides thetaiotaomicron VPI-5482],2JIW_B Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with 2- Acetylamino-2-deoxy-1-epivalienamine [Bacteroides thetaiotaomicron VPI-5482]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q89ZI2	7.59e-154	8	710	4	697	O-GlcNAcase BT_4395 OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4395 PE=1 SV=1
Q0TR53	1.56e-90	115	528	126	540	O-GlcNAcase NagJ OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=nagJ PE=1 SV=1
Q8XL08	4.12e-90	115	528	126	540	O-GlcNAcase NagJ OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagJ PE=1 SV=1
P26831	5.06e-43	94	746	103	795	Hyaluronoglucosaminidase OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagH PE=1 SV=2
Q8VIJ5	1.31e-36	179	450	63	339	Protein O-GlcNAcase OS=Rattus norvegicus OX=10116 GN=Oga PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.001193	0.746147	0.251791	0.000328	0.000273	0.000254

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001433_01251.