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CAZyme Information: MGYG000001437_00576

You are here: Home > Sequence: MGYG000001437_00576

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Staphylococcus schleiferi
Lineage Bacteria; Firmicutes; Bacilli; Staphylococcales; Staphylococcaceae; Staphylococcus; Staphylococcus schleiferi
CAZyme ID MGYG000001437_00576
CAZy Family CBM40
CAZyme Description Sialidase B
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
701 MGYG000001437_1|CGC10 79077.77 8.7241
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001437 2461191 Isolate not provided not provided
Gene Location Start: 606132;  End: 608237  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 4.2.2.15 3.2.1.18

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH33 231 675 2.8e-69 0.956140350877193
CBM40 43 223 6.5e-51 0.9664804469273743

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4409 NanH 0.0 42 693 74 727
Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
cd15482 Sialidase_non-viral 4.76e-47 231 681 2 338
Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam02973 Sialidase 8.46e-26 42 226 7 188
Sialidase, N-terminal domain.
pfam13088 BNR_2 6.91e-16 454 623 78 251
BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QGS47276.1 0.0 1 701 1 701
CAD7360084.1 0.0 1 701 1 701
QHW38358.1 0.0 1 694 1 694
QBG68192.1 0.0 1 694 1 694
ADX76869.1 0.0 1 694 1 694

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4YW1_A 0.0 41 693 4 656
ChainA, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW1_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW2_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW2_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW3_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW3_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW4_A Streptococcus pneumoniae sialidase NanC [Streptococcus pneumoniae],4YW4_B Streptococcus pneumoniae sialidase NanC [Streptococcus pneumoniae],4YW5_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW5_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],5F9T_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],5F9T_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4]
4YZ1_A 0.0 38 693 20 675
CrystalStructure of Streptococcus pneumoniae NanC, apo structure. [Streptococcus pneumoniae TIGR4],4YZ1_B Crystal Structure of Streptococcus pneumoniae NanC, apo structure. [Streptococcus pneumoniae TIGR4],4YZ2_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid. [Streptococcus pneumoniae],4YZ2_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid. [Streptococcus pneumoniae],4YZ3_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir. [Streptococcus pneumoniae TIGR4],4YZ3_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir. [Streptococcus pneumoniae TIGR4],4YZ4_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with N-Acetylneuraminic acid. [Streptococcus pneumoniae],4YZ4_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with N-Acetylneuraminic acid. [Streptococcus pneumoniae],4YZ5_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with 3-Sialyllactose [Streptococcus pneumoniae],4YZ5_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with 3-Sialyllactose [Streptococcus pneumoniae]
4XYX_A 2.78e-212 39 696 1 660
NanBplus Optactamide [Streptococcus pneumoniae]
4XE9_A 3.68e-212 39 692 2 657
Crystalstructure of the NanB sialidase from Streptococcus pneumoniae in complex with Optactin [Streptococcus pneumoniae TIGR4],4XHB_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with pentanediol and CHES [Streptococcus pneumoniae TIGR4],4XHX_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin and 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae TIGR4],4XIK_A Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO [Streptococcus pneumoniae TIGR4],4XIL_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with MPD as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XIO_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJ8_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 5.0 in 50mM sodium Acetate with DMSO [Streptococcus pneumoniae TIGR4],4XJ9_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 5.0 in 50mM Sodium Acetate with DMSO as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJA_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid [Streptococcus pneumoniae TIGR4],4XJU_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid [Streptococcus pneumoniae TIGR4],4XJW_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJZ_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 7.4 in PBS with DMSO [Streptococcus pneumoniae TIGR4]
4XOG_A 3.94e-212 39 692 4 659
CRYSTALSTRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH Optactin and DANA [Streptococcus pneumoniae TIGR4]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q54727 5.27e-211 39 692 40 695
Sialidase B OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=nanB PE=1 SV=2
Q27701 1.90e-162 40 692 85 755
Anhydrosialidase OS=Macrobdella decora OX=6405 PE=1 SV=1
P29767 1.87e-58 41 666 193 809
Sialidase OS=Clostridium septicum OX=1504 PE=3 SV=1
P31206 7.94e-12 463 666 320 526
Sialidase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=nanH PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000000 0.000000 1.000058 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001437_00576.