CAZyme Information: MGYG000001448_00439

Basic Information

• Species: Dermabacter hominis
• Lineage: Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Dermabacteraceae; Dermabacter; Dermabacter hominis
• CAZyme ID: MGYG000001448_00439
• CAZy Family: GT2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
320	MGYG000001448_1|CGC5	34119.45	5.1496

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001448	2361290	Isolate	not provided	not provided

• Gene Location: Start: 450030; End: 450992 Strand: -

Full Sequence      

MSSVDAAQMGGARPTRVAVVIPAKDEAERIERTVAASFTIRGVDLVVVVDDGSSDATAAL
AKGAGAVVVRHRTNRGKAAAMATGARVVHMREETEHAERLNAAAIPSQAVEPPRALLFID
ADMQDSASGAQPLVEAVLEDGVDMAIATLPAQEGAAGMGFVVKTARNGIRKATGFETVQP
LSGTRCITRETWDAVQPLAAGWGVETGLTIDALHQGFWVKEIPADLTHRATGKDLRSQLH
RANQLKDVMRALSKRRSLSPNDPLGEDGEVRTLTGDRTEAPEFVENPPVKHFAVPSLEKN
AQVKAPSEEPVDEPREEPEQ

Enzyme Prediction     

No EC number prediction in MGYG000001448_00439.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd04179	DPM_DPG-synthase_like	4.19e-19	19	195	1	166	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.
PRK13915	PRK13915	2.39e-10	13	214	29	227	putative glucosyl-3-phosphoglycerate synthase; Provisional
pfam00535	Glycos_transf_2	1.22e-07	19	151	2	117	Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
cd02522	GT_2_like_a	6.45e-07	17	86	1	69	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function. Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
cd04188	DPG_synthase	9.30e-06	19	233	1	211	DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ATH97531.1	3.94e-199	9	320	1	312
QEU11122.1	1.26e-172	1	319	1	321
ATG52869.1	1.94e-96	13	282	11	299
APX34160.1	6.42e-93	13	267	11	282
AXK44292.1	1.00e-89	13	282	11	295

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q58619	7.05e-06	19	146	21	127	Uncharacterized protein MJ1222 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) OX=243232 GN=MJ1222 PE=4 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000039	0.000003	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001448_00439.