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CAZyme Information: MGYG000001481_03058
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Neobacillus sp000821085 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Bacillales_B; DSM-18226; Neobacillus; Neobacillus sp000821085 | |||||||||||
| CAZyme ID | MGYG000001481_03058 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 2987813; End: 2989528 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd05969 | MACS_like_4 | 0.0 | 74 | 559 | 1 | 442 | Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS). This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria. |
| COG0365 | Acs | 0.0 | 35 | 568 | 1 | 528 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]. |
| PRK00174 | PRK00174 | 0.0 | 24 | 571 | 50 | 622 | acetyl-CoA synthetase; Provisional |
| PRK04319 | PRK04319 | 0.0 | 1 | 571 | 1 | 570 | acetyl-CoA synthetase; Provisional |
| cd05966 | ACS | 0.0 | 25 | 571 | 35 | 608 | Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme). Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 7.77e-105 | 18 | 571 | 597 | 1202 |
| CAE6201338.1 | 8.96e-105 | 18 | 571 | 608 | 1213 |
| CAE6256584.1 | 4.48e-33 | 86 | 554 | 1596 | 2055 |
| BAY90071.1 | 1.13e-26 | 19 | 556 | 2678 | 3198 |
| BAY30132.1 | 8.15e-25 | 19 | 556 | 2689 | 3209 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7KCP_A | 4.35e-110 | 33 | 571 | 100 | 667 | ChainA, Acetyl-coenzyme A synthetase [Coccidioides posadasii C735 delta SOWgp] |
| 7KQ6_A | 6.11e-110 | 33 | 571 | 100 | 667 | ChainA, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7KQ6_B Chain B, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7KQ6_C Chain C, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7KQZ_A Chain A, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7KVY_A Chain A, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7L3P_A Chain A, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7L3Q_A Chain A, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7L3Q_B Chain B, Acetyl-coenzyme A synthetase [Coccidioides immitis RS],7L3Q_C Chain C, Acetyl-coenzyme A synthetase [Coccidioides immitis RS] |
| 2P2F_A | 4.56e-109 | 36 | 571 | 69 | 628 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 5JRH_A | 5.63e-109 | 36 | 571 | 69 | 628 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
| 2P2Q_A | 6.42e-109 | 36 | 571 | 69 | 628 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P39062 | 0.0 | 1 | 571 | 1 | 572 | Acetyl-coenzyme A synthetase OS=Bacillus subtilis (strain 168) OX=224308 GN=acsA PE=1 SV=1 |
| A0B8F1 | 1.83e-137 | 36 | 569 | 83 | 646 | Acetyl-coenzyme A synthetase OS=Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) OX=349307 GN=acsA PE=1 SV=1 |
| A4WJG1 | 5.60e-136 | 14 | 571 | 43 | 649 | Acetyl-coenzyme A synthetase OS=Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) OX=340102 GN=acsA PE=3 SV=1 |
| O93730 | 3.14e-135 | 14 | 571 | 43 | 649 | Acetyl-coenzyme A synthetase OS=Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) OX=178306 GN=acsA PE=3 SV=2 |
| Q8DKH2 | 5.06e-130 | 15 | 571 | 57 | 645 | Acetyl-coenzyme A synthetase OS=Thermosynechococcus vestitus (strain IAM M-273 / NIES-2133 / BP-1) OX=197221 GN=acsA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000047 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |