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CAZyme Information: MGYG000001483_01551

You are here: Home > Sequence: MGYG000001483_01551

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Arachnia massiliensis
Lineage Bacteria; Actinobacteriota; Actinomycetia; Propionibacteriales; Propionibacteriaceae; Arachnia; Arachnia massiliensis
CAZyme ID MGYG000001483_01551
CAZy Family CBM32
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1811 195719.65 4.1366
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001483 3211248 Isolate not provided not provided
Gene Location Start: 118090;  End: 123525  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.97 3.2.1.140

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH101 232 888 1.4e-183 0.9957567185289957
CBM51 1366 1506 7e-40 0.9776119402985075
CBM32 46 196 7.8e-16 0.967741935483871

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam12905 Glyco_hydro_101 3.68e-141 477 750 1 273
Endo-alpha-N-acetylgalactosaminidase. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Endo-alpha-N-acetylgalactosaminidase, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.
cd14244 GH_101_like 1.21e-124 492 773 3 298
Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases. This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates.
pfam08305 NPCBM 7.43e-48 1363 1507 1 135
NPCBM/NEW2 domain. This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)
pfam18080 Gal_mutarotas_3 7.84e-48 229 476 1 243
Galactose mutarotase-like fold domain. This domain is found in endo-alpha-N-acetylgalactosaminidase present in Streptococcus pneumoniae. Endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase involved in the breakdown of mucin type O-linked glycans. The domain, known as domain 2, exhibits strong structural similarlity to the galactose mutarotase-like fold but lacks the active site residues. Domains, found in a number of glycoside hydrolases, structurally similar to domain 2 confer stability to the multidomain architectures.
smart00776 NPCBM 2.03e-43 1361 1507 1 144
This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QXT63218.1 0.0 13 1541 2 1548
AZR07626.1 0.0 5 1379 7 1425
QOR48245.1 0.0 1 1337 1 1375
AWG15846.1 0.0 5 1379 7 1425
AWG03117.1 0.0 5 1379 7 1425

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2ZXQ_A 9.63e-123 222 1220 15 1089
Crystalstructure of endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum (EngBF) [Bifidobacterium longum]
6QFO_A 6.58e-122 229 1220 12 1074
EngBFDARPin Fusion 9b 3G124 [Bifidobacterium longum]
6QEP_A 1.07e-121 229 1220 12 1074
EngBFDARPin Fusion 4b H14 [Bifidobacterium longum]
6QFK_A 1.12e-121 229 1220 12 1074
EngBFDARPin Fusion 4b G10 [Bifidobacterium longum]
6QEV_B 1.12e-121 229 1220 12 1074
EngBFDARPin Fusion 4b B6 [Bifidobacterium longum]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A9WNA0 5.67e-253 221 1598 43 1398
Putative endo-alpha-N-acetylgalactosaminidase OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=RSal33209_1326 PE=3 SV=2
Q2MGH6 2.46e-102 200 1181 309 1333
Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0368 PE=1 SV=1
Q8DR60 1.02e-101 200 1181 309 1333
Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=spr0328 PE=1 SV=1
Q6GDE9 1.45e-08 1517 1604 661 749
Serine-rich adhesin for platelets OS=Staphylococcus aureus (strain MRSA252) OX=282458 GN=sasA PE=3 SV=1
Q6G620 1.60e-08 1517 1604 661 749
Serine-rich adhesin for platelets OS=Staphylococcus aureus (strain MSSA476) OX=282459 GN=sraP PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000468 0.998644 0.000209 0.000279 0.000209 0.000184

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001483_01551.