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CAZyme Information: MGYG000001485_03033
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Pseudomonas_E massiliensis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas_E; Pseudomonas_E massiliensis | |||||||||||
| CAZyme ID | MGYG000001485_03033 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 927578; End: 929533 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd17634 | ACS-like | 0.0 | 24 | 611 | 1 | 587 | acetate-CoA ligase. This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain. |
| TIGR02188 | Ac_CoA_lig_AcsA | 0.0 | 18 | 644 | 1 | 626 | acetate--CoA ligase. This model describes acetate-CoA ligase (EC 6.2.1.1), also called acetyl-CoA synthetase and acetyl-activating enzyme. It catalyzes the reaction ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA and belongs to the family of AMP-binding enzymes described by pfam00501. |
| PLN02654 | PLN02654 | 0.0 | 24 | 642 | 32 | 661 | acetate-CoA ligase |
| PRK00174 | PRK00174 | 0.0 | 6 | 649 | 1 | 637 | acetyl-CoA synthetase; Provisional |
| cd05967 | PrpE | 0.0 | 24 | 641 | 1 | 617 | Propionyl-CoA synthetase (PrpE). EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 6.43e-239 | 24 | 642 | 582 | 1210 |
| CAE6201338.1 | 8.79e-239 | 24 | 642 | 593 | 1221 |
| AFZ04852.1 | 3.22e-22 | 79 | 615 | 587 | 1074 |
| CAE6256584.1 | 3.11e-14 | 261 | 618 | 1714 | 2058 |
| AFY93865.1 | 5.36e-14 | 79 | 624 | 334 | 851 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2P2Q_A | 0.0 | 1 | 649 | 1 | 649 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2J_A | 0.0 | 1 | 649 | 1 | 649 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2J_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2M_A | 0.0 | 1 | 649 | 1 | 649 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2F_A | 0.0 | 1 | 649 | 1 | 649 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 5JRH_A | 0.0 | 1 | 649 | 1 | 649 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q4ZQG8 | 0.0 | 1 | 651 | 1 | 651 | Acetyl-coenzyme A synthetase OS=Pseudomonas syringae pv. syringae (strain B728a) OX=205918 GN=acsA PE=3 SV=1 |
| Q87KU7 | 0.0 | 1 | 642 | 1 | 643 | Acetyl-coenzyme A synthetase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) OX=223926 GN=acsA PE=3 SV=1 |
| Q7MGU3 | 0.0 | 1 | 642 | 1 | 643 | Acetyl-coenzyme A synthetase OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=acsA PE=3 SV=2 |
| Q6LLZ1 | 0.0 | 1 | 642 | 1 | 642 | Acetyl-coenzyme A synthetase OS=Photobacterium profundum (strain SS9) OX=298386 GN=acsA PE=3 SV=1 |
| Q885K7 | 0.0 | 1 | 651 | 1 | 651 | Acetyl-coenzyme A synthetase OS=Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) OX=223283 GN=acsA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999992 | 0.000061 | 0.000005 | 0.000000 | 0.000000 | 0.000001 |