CAZyme Information: MGYG000001500_01131

Basic Information

• Species: Lawsonibacter asaccharolyticus
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; Lawsonibacter; Lawsonibacter asaccharolyticus
• CAZyme ID: MGYG000001500_01131
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
894	MGYG000001500_10|CGC3	98601.4	4.1933

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001500	3446570	Isolate	not provided	not provided

• Gene Location: Start: 1000228; End: 1002912 Strand: +

Full Sequence      

MSEEQNSRLYNENNDYGERDYAPRKPGKKKKRKESGGHVGRRILQVLGTLLLVGLCTGAI
LCCFAAVYIKTVIIPEAGAVDLSQFAVGENSVMYYMDQDTGNYRELVTLAAEENAEWVNY
EDIPEDLINATVAIEDRRFWEHNGVDWKRTAAAILYMFTGQDIQGGSTITQQLIKNLTQY
DDVTVKRKVIEIFRALQFDKDYTKETTLEWYLNFIWLGDRCRGVGAAAMNYFGKPVQELT
LAECASLISITNNPTIYGPYSDAVFTNSETGEQKTARDKNKERQELVLWSMLDQGYITQE
EYDEAVAQELVFDRAAGESTPSTIYSWYEEQVISDVKDDLKAQYGYSDEAVSLLLTRGGL
SIYTCVDPDVQAQVEQIYSDRTNLDYTSSSGQQLQSAITVIDNETGNLVGIAGRVGEKTG
NLWMNFATDSKRQPGSSIKPLSVYAPAFEMGLISPISVLDDYPHEVMGGRPWPVNVDGRY
RGLVTVRQALSNSYNTVSVRVLADLVTPENSFNFVEEHFHLDLEDGVEIGGQMKSDIGVA
PLSMGGLTYGVNTRDMAEAFAVFPNGGLYQKSRTYTKVTREVDGVETVLLENQPESEAVL
KSETAYYVNSILREVVTRVNTSGNFDSGMAIAGKTGTTDDKYDRWFVGYTPYYTAAVWVG
FEQNERVPASGNPALKMWTLVMSGVHEGLEDRKFSEPAGLTTVTYCLDSGLLATDYCRMD
PRGDRTARGTVFQGDAPTEFCTSHTAETTVTVCLDCPILDGNGEETGLYHLAGEFCPEES
RQEVSLLGYQREDVGGASAEDAKYFLGVTQEAGPCTVHTTAQPDPDLPFDPNQPWDPSDP
WNPNTNPLDPTGQGGGGAADPGQEDPDAPQGGETEDPSGTDPIINPETGRPYGY

Enzyme Prediction     

No EC number prediction in MGYG000001500_01131.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	108	291	2.2e-56	0.9548022598870056

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	3.12e-157	114	688	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	3.84e-153	77	734	42	647	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	2.18e-112	105	769	57	797	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	7.60e-81	106	683	135	680	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	7.86e-74	117	668	60	542	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIA31344.1	1.56e-283	27	828	14	815
ANU41033.1	7.28e-281	45	828	8	791
ALP94484.1	2.02e-265	26	822	16	808
QBB65500.1	2.05e-262	45	822	3	776
QNL43378.1	3.26e-214	40	825	23	782

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	5.42e-70	113	715	38	791	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
3DWK_A	1.71e-50	105	666	16	562	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
3ZG8_B	4.52e-50	197	666	2	437	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3UDF_A	5.87e-48	118	688	42	718	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
2OLU_A	2.35e-47	105	666	25	571	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A7GHV1	1.96e-105	27	744	2	702	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A5I6G4	2.92e-105	27	744	2	702	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	2.92e-105	27	744	2	702	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
Q0TNZ8	8.41e-100	86	745	67	725	Penicillin-binding protein 1A OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=pbpA PE=3 SV=1
Q0SRL7	1.83e-98	86	745	67	725	Penicillin-binding protein 1A OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999906	0.000102	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
47	69