CAZyme Information: MGYG000001514_04163

Basic Information

• Species: Paenibacillus_A ihumii
• Lineage: Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus_A; Paenibacillus_A ihumii
• CAZyme ID: MGYG000001514_04163
• CAZy Family: GT2
• CAZyme Description: D-alanine--poly(phosphoribitol) ligase subunit 1

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2631	MGYG000001514_12|CGC49	295525.33	5.0557

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001514	5923787	Isolate	not provided	not provided

• Gene Location: Start: 2930702; End: 2938597 Strand: -

Full Sequence      

MAENKKIILWQNHSPGGEELAPTMIPYSKALGGKNTTWMKAVRTLEEELSVSLLEECRHD
YSELLAFLLAGIQGLLYRYTGDSQITIGLPYADSENAGGRMHILLHSRPISAKDTFELMI
EGNRQLALLLSAAQGLPLEERAEELCLRRLSGQLRTPVLAGLSNFYHFEDSDLALADLAI
ELEERGGALYLGFLYRADLYEQAFIEQASSHLERLLQAALKNRQTELLVLDMLSAQEKKL
VLDNFNRHDMDYPKEVMFHQWFEAEAERHPDAIAVQYKEERLTYRELNARANQLARTLRQ
CGVKPNELVGILVERCVGMVVSVLAVWKSGAAYVPIDPEYPEERIRFMLEDSEASVLLTQ
RHLQKLAADWSSAAGKEGSGVLYLEDEGIYDDETANLKPVQQTTDLAYVIYTSGTTGRPK
GVMIDHFSFMNTAAGYRREFRLGDFPVRLLQLASFSFDVFVGDIARTFYNGGAMVICPKE
DRIDPNRLFRWIRDQQITVFESTPALIIPFMKHVADQGLALSSMKLLITSSDSCSVKDYR
WLQERFGSQFRIINSYGVTEAAIDSSLYDEPLSKLPDSGSVPIGRAVLNARFYIVDEALQ
PVPIGVLGELCIGGDGVAKGYWKRPELTAEKFIASPFVPGERLYRTGDLARWMPDGNVDF
VGRMDHQAKIRGYRIEVGEVEAHMQKEPSVREVVVAVREEESGEKALCAYYVADRPIRGS
DWRERLSASLPDYMIPSYFIAMDKLPLTANGKVDRKALPQPGALQQHIQAEVAAGIEGLG
GGRHPVVRMSAKVTHHALLDSQALAEAYSIRPGERIYQSDSAYMDASCQEMLLPLLHGAT
LCLPEKSGLPAERSAQYLQENSIAVAHLGEDELRAVPQEELPCLRLVTTNSRTVSPELIH
AWAEHRSFSVLYGAAGAGPLIHAYYSESCSSASTGLPLPGKELYVLNDWLQLMPPGIPGE
LYAGAAGMELALYENGMPERLVDHPWVPGAKLIRTGILARYLENGELQYIGELGLPDAEG
GSDAERHSGLEAGISSRAVRNRTEEQLLRIWQEILGREQIGLREDFFAVGGHSLRAMTLL
SRIQKIFQVEISLQAILAHPTIEELAGYIKQAQSISYQAISPAEQQAYYPVTSVQQRLYS
VQQFAGIGTSYHIPLLLELRGPLQKERLAEALHALVRRHEAFRTSFHLVQGELMQQIHEE
VDFRVEFGSVGSDEELEAYAEGFTRPFDLSRAPLFRAAIVELGRHKHYLLMDANHIVYDG
LSGDTVLDELMKLYRGEILPALPIQYKDYAVWQHNALEKGGMKRHEEYWLEQFKGPLPAL
ELPADYPRPAIKKFDGDLVTVPLPEELKAKLARFMEEHQASLYATLLSVYGIMLSKYANE
EDIVVGTTTAGRSHPDLESVVGMFANTLGLRLYPDASKPFAEFLAQVKETVFGALEHEEY
PLEELIRRLGLQRDISRNPLFDTMFVLEAHSASSERFMGIEHNLHNPSWKYSKLDLTWYV
QEGASGQLQILVEYSTQLFMKATIQRMAGHYLQLLAQAIDNPQAAIQELACITEGERRQI
LTDFNNTRFAYPPFRPLHVIFEEQAEQTPDAVALLYGGGQMTYREVNERANQLGRRLRAH
GVGRDQAVGILFDRSFEMMISILAVLKAGGAYMPLSPEFPRERIEYMASNSRIKLLLTER
KYADLAEGLASVTIYADQPEAYGEDGSNLAHIHQERDLAYILYTSGSTGRPKGVMIEHYT
VYNRIAWMVKEYGISREDVFLQKTPYVFDVSVWELFMWFFTGASLCLLPAGEEKAPDRMI
DCMHRSGVTSIHFVPSMLGSFLDFMEMPAYMGQLARLRRIFTSGEALLPSHVARFQQAGH
AQARLYNLYGPTEATIDVSYYHCPVQGEPRTVPIGKPIDNVQLFILNRQDQLQPVGVPGE
LCISGACLARGYMNRDDLTLASFVPNPYLEGQLMYRTGDLARWLPDGNIEYLGRIDNQVK
IRGYRIELDEITTRLLEIEGVREAAAIARQDAGGAPYLCAYYVGAEQGILQPAAMKSELL
RSLPDYMVPAHFIEMPALPVNHNGKLDRKALPEPAFTVEKEYEAPESEKERLLVEIWEKV
LHVGRVGVNDNFFELGGDSIKAIHVAAQLNQHELKIDMTEFFQNPTVRALAPLLKEGTIR
AEQGIVRGDGTLTPIQQWFFEQPVSNRNHWNQSVLLQRASGWDIEAVKQAWSRLTEHHDA
LRIVFREEEGGRSFTHRDPDAEIFGFDSWVIDEDNDITAWIREKGDELHRSLDIEEGPLI
RLGHFRSGEGEYLLIVMHHLIVDGVSWSILLEDFAAVYGQIDSGQPVRLPAKTTSFLDWS
KQLQDYADSDEFLNQLSYWKDIDSQVEACAALPAGVHACEAGQRYKEVELKLDGHFTEQL
LTTIHQAYRTEVNDILLAALTLAVTRWTGEESMAVSLEGHGREQLMAGVDLSRTVGWFTS
LYPVVFRLQSSAIPHVIKAVKETLRSVPHKGAGYGILRYMTSPGSKGHHRFCSQPRILFN
YLGQLGAGEEGGFKLSDAPAGSAASDYVEPLYWLEINGMVVNGELRLVIGYDAAKFDLRT
MEELRNSFKEHLEQVIQHCAEAEGTELTPSDFSARELSLEELDDIFEALKQ

Enzyme Prediction     

No EC number prediction in MGYG000001514_04163.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd17655	A_NRPS_Bac	0.0	260	761	1	489	bacitracin synthetase and related proteins. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
PRK12316	PRK12316	0.0	178	2623	1928	4090	peptide synthase; Provisional
cd17655	A_NRPS_Bac	0.0	1581	2075	3	490	bacitracin synthetase and related proteins. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
PRK12316	PRK12316	0.0	45	2154	2826	5139	peptide synthase; Provisional
PRK12316	PRK12316	0.0	1105	2623	25	1544	peptide synthase; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QND46664.1	2.80e-284	127	2160	897	2668
BAY30132.1	1.44e-189	1044	2156	2149	3296
BAY90071.1	2.52e-189	1044	2156	2138	3285
BAZ75991.1	2.50e-188	1044	2156	2147	3294
BAZ00088.1	2.50e-188	1044	2156	2147	3294

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6MFZ_A	0.0	226	2154	185	1797	Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis]
6MFY_A	5.49e-315	226	2078	185	1719	Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis]
6P1J_A	2.12e-215	1129	2071	6	964	Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae]
6OYF_A	8.06e-188	1130	1983	4	873	Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module [Eleftheria terrae],6OZV_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with AMP [Eleftheria terrae],6P4U_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg and AMP [Eleftheria terrae]
6P3I_A	8.91e-182	1130	1983	4	873	Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg [Eleftheria terrae]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39847	0.0	186	2625	394	2548	Plipastatin synthase subunit C OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsC PE=1 SV=2
Q04747	0.0	45	2631	1268	3580	Surfactin synthase subunit 2 OS=Bacillus subtilis (strain 168) OX=224308 GN=srfAB PE=1 SV=3
P94459	0.0	31	2629	1254	3600	Plipastatin synthase subunit D OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsD PE=1 SV=2
Q70LM4	0.0	200	2623	407	2569	Linear gramicidin synthase subunit D OS=Brevibacillus parabrevis OX=54914 GN=lgrD PE=1 SV=1
P39846	0.0	186	2631	401	2559	Plipastatin synthase subunit B OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsB PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999921	0.000107	0.000006	0.000000	0.000000	0.000003

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001514_04163.