CAZyme Information: MGYG000001550_01151

Basic Information

• Species: Christensenella timonensis
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; Christensenellaceae; Christensenella; Christensenella timonensis
• CAZyme ID: MGYG000001550_01151
• CAZy Family: GH73
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1376	MGYG000001550_2|CGC6	149649.94	4.8583

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001550	2650850	Isolate	not provided	not provided

• Gene Location: Start: 880391; End: 884521 Strand: +

Full Sequence      

MLMALTCVAAFGLTTFTGTQTAEAAGSKGVIFINPGHSPSSKTSGTSGTNPDGSVITEDY
MNEWSSHLLGKKLQSLGYTVYLTNIMTYSSDLPVIITTPPASNNDYGGRQYQFRDNPENG
TKGELIPACNNPSSVNPSVTVKPDLIITMHRNSVEGNSTSNGLLVGYSTHTGDGRSSDIV
TRSKYASDQISAQFSTNMKSYFKSSNSVTWISNSIIKYSLAPSIIIEAGFMTNASDLANM
QKTACQTALMDSIANGVESFFAKYPTSNTNIAGIYYNADTTTAKTSFDVSAVINGSAAGA
EMVIWNTNYDRATTGYTYKATKLSDGGWHVTFDQKKHGGLPGKYSIEVYALDAKGNRVAS
DYKYVTTTTDLTKPTTKGIYYDADSTTAKTKFDISAVVEAGVDRDISKVEITVWNTDVGR
SQTSYTYSGQKLSDGGWHATFDVSKHGGKSGKYSIEVYVTDNKGVRHATTYKYVTLQISE
PTGTIYYDAASTTDKTKFDISAVVKPGSSDISKVEIEVWNASVGKAQTSYTYAGQKLSDG
GWHATFDAYKHGGKGGTYTIKVYATDSEGIRYEVAEKNVTVNIAKPTTTGIYYDADNTTN
KTQFDISAVVKAGSNDISKVEITVWNTDVGRSQTSYTYSGQKLSDGGWHATFDAYKHGGK
GGKYSIEVYVTDSKGVRYDTIYKYVTVNIIPPTAAIYYDTASTTTKTKFDISTVVTPGSN
TISKVDIEVWNASVGQSQTSYTYAGQKLSDGGWHATFDVSKHGGKGGTYTIKTYVTDSKG
VRYELAQKDVAVTITKPTLSGIYYDANSTTNKTSFDISAVVKKGTFDISKVEITVWNTNV
GRSQTSYTYTGQKLSDGGWHATFDVNKHGGQSGQYSIEVYVTDSAGARYDTSFKYVNVKT
GVTPIMGTSEATVAQMVNFYNASKKTYPTYYTQRGVNLQQFAQLYYDVCKTEGVRAEVAW
AQMCLETGYLQFGGDVKIGQFNFAGLGATGGGVPGFDFSAVYGDNANGIKHGIIGHVQHL
KCYACSDAVVYKDSAGKPIDPRWADYLRGKSPSVEGLSGTWAASGTYGQDIVDMMDRILA
QAKTMTASSTMDVLEEMEPVPAPSNEAVNTPDMDEAAPSATPAPETTEEPIEETEPDYAI
MRQGEEIGAVEEQLVNYYIENVKGLPMEVRDKAGNILPVDAQTGFPQYYGMSLEEFVRLY
MEEARAEGVNPEVAFAQAMIDTDFLRFDNGNDLAIENYVFSAEDVSVEKPGGIISYATVR
EGIRAQIQHLKCYASMDDCVRTVVDLQWQEDIRGTIKDAALLGGGVWYQDAGYGEKLVDA
IKKILEQPGQIRYLEVQPEERKMPSEPTPEQQQNEENTEQQELAEPDATQTETPAE

Enzyme Prediction     

No EC number prediction in MGYG000001550_01151.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd02696	MurNAc-LAA	1.38e-14	30	257	1	171	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.
pfam01520	Amidase_3	1.57e-14	31	257	1	172	N-acetylmuramoyl-L-alanine amidase. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.
COG0860	AmiC	1.59e-12	27	263	41	230	N-acetylmuramoyl-L-alanine amidase [Cell wall/membrane/envelope biogenesis].
pfam08481	GBS_Bsp-like	1.10e-09	705	782	7	83	GBS Bsp-like repeat. This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.
pfam08481	GBS_Bsp-like	1.13e-09	388	469	7	86	GBS Bsp-like repeat. This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AYH39207.1	1.34e-130	30	1104	37	1002
AFA47045.1	6.26e-99	13	1077	21	942
AWW27119.1	7.60e-95	31	1077	39	943
QUO33462.1	5.58e-71	144	1078	326	1339
ARD65351.1	9.00e-69	400	1078	297	950

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O51481	4.34e-15	942	1079	72	196	Uncharacterized protein BB_0531 OS=Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) OX=224326 GN=BB_0531 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000576	0.998366	0.000214	0.000314	0.000260	0.000230

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001550_01151.