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CAZyme Information: MGYG000001562_00428

You are here: Home > Sequence: MGYG000001562_00428

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Alistipes timonensis
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes timonensis
CAZyme ID MGYG000001562_00428
CAZy Family GH20
CAZyme Description Beta-hexosaminidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
544 MGYG000001562_11|CGC6 60765.31 5.7092
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001562 3488594 Isolate not provided not provided
Gene Location Start: 277224;  End: 278858  Strand: -

Full Sequence      Download help

MGKLRILLAL  GVLCCGCGRV  VPVDGPVSVV  PAPVSVTPAE  GVFRLSASTR  VVVRSSDGRM60
PFVTDALNEL  LRPVFGEELT  CLSPAPVQDG  AVNFIETDSI  SSDGYSLTIT  PDRVEVRSGG120
AEGAFYAVQT  LRQLMPAAAF  GKGRAKAVEL  PAVAIADRPE  MGYRGMMLDV  ARHFFTVEEV180
KRVLDLLAMH  KMNVFHWHLT  DDQGWRIEIG  KYPELTRIGS  VRTRTLIGKD  PGGEYDETCR240
YDETPHGGFY  TQDEIRDVVE  YAARRFITVI  PEIEFPGHAV  AALASYPWLS  CTGEQYEVRQ300
TWDIDDRVFC  IGRDSTFRFI  EGVLEEVVAL  FPSTYIHIGG  DECPTDRWEQ  CPRCRERMRA360
EGLTRPRQLQ  GYATTRIERF  LRSHGRRLIG  WDEILDSGVS  RTAVVMSWRG  TEGGIRAARQ420
GNEVVMAPTT  HCYFDYYQTA  DTAGEPLAWG  GCLPLEKVYA  LSPCERLDSV  QRASVLGVQA480
NLWTEYIPDF  AQAQYMLLPR  LGALAEVGWS  PGRKDYAEFL  PRLKRLTRFY  DACGYVYAKH540
SLAD544

Enzyme Prediction      help

EC 3.2.1.52

CAZyme Signature Domains help

Created with Snap275481108136163190217244272299326353380408435462489516162511GH20
Family Start End Evalue family coverage
GH20 162 511 7.5e-121 0.9554896142433235

CDD Domains      download full data without filtering help

Created with Snap275481108136163190217244272299326353380408435462489516162523GH20_chitobiase-like162511Glyco_hydro_2038537Chb162523GH20_SpHex_like163523GH20_chitobiase-like_1
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06563 GH20_chitobiase-like 0.0 162 523 2 357
The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
pfam00728 Glyco_hydro_20 6.22e-169 162 511 2 345
Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold.
COG3525 Chb 6.58e-130 38 537 138 642
N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism].
cd06568 GH20_SpHex_like 5.30e-109 162 523 2 329
A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases.
cd06570 GH20_chitobiase-like_1 8.21e-89 163 523 3 311
A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This subgroup lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.

CAZyme Hits      help

Created with Snap2754811081361631902172442722993263533804084354624895165542BBL07016.1|GH204544BBL07924.1|GH204544BBL10715.1|GH204544BBK99899.1|GH2014540AFL78928.1|GH20
Hit ID E-Value Query Start Query End Hit Start Hit End
BBL07016.1 8.80e-279 5 542 9 555
BBL07924.1 6.75e-273 4 544 1 544
BBL10715.1 6.75e-273 4 544 1 544
BBK99899.1 6.75e-273 4 544 1 544
AFL78928.1 4.77e-269 14 540 17 543

PDB Hits      download full data without filtering help

Created with Snap27548110813616319021724427229932635338040843546248951635406Q63_A825397CBN_A295233RCN_A575407DUP_A575407DVB_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
6Q63_A 8.94e-166 3 540 6 539
BT0459[Bacteroides thetaiotaomicron],6Q63_B BT0459 [Bacteroides thetaiotaomicron],6Q63_C BT0459 [Bacteroides thetaiotaomicron]
7CBN_A 3.94e-118 82 539 56 512
Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835]
3RCN_A 4.23e-109 29 523 10 498
CrystalStructure of Beta-N-Acetylhexosaminidase from Arthrobacter aurescens [Paenarthrobacter aurescens TC1]
7DUP_A 7.94e-100 57 540 17 523
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_A Chain A, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVA_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]
7DVB_A 4.40e-99 57 540 17 523
ChainA, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_B Chain B, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_C Chain C, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron],7DVB_D Chain D, Beta-N-acetylhexosaminidase [Bacteroides thetaiotaomicron]

Swiss-Prot Hits      download full data without filtering help

Created with Snap27548110813616319021724427229932635338040843546248951624537sp|P49008|HEXA_PORGI82539sp|B2UQG6|H0868_AKKM828508sp|P96155|HEX1_VIBFU96529sp|B2UP57|H2018_AKKM827535sp|Q7WUL4|HEX20_CELFI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
P49008 2.09e-136 24 537 32 532
Beta-hexosaminidase OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619 GN=nahA PE=3 SV=2
B2UQG6 3.00e-117 82 539 75 531
Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1
P96155 1.29e-89 28 508 140 604
Beta-hexosaminidase OS=Vibrio furnissii OX=29494 GN=exoI PE=1 SV=1
B2UP57 3.28e-71 96 529 51 468
Beta-hexosaminidase Amuc_2018 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2018 PE=1 SV=1
Q7WUL4 2.80e-69 27 535 4 475
Beta-N-acetylhexosaminidase OS=Cellulomonas fimi OX=1708 GN=hex20 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000000 0.000000 1.000064 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001562_00428.