CAZyme Information: MGYG000001625_00134

Basic Information

• Species: Eikenella corrodens
• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Burkholderiales; Neisseriaceae; Eikenella; Eikenella corrodens
• CAZyme ID: MGYG000001625_00134
• CAZy Family: GT2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
554	MGYG000001625_6|CGC1	62186.46	9.3616

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001625	1812730	MAG	China	Asia

• Gene Location: Start: 13665; End: 15329 Strand: +

Full Sequence      

MKLLAVIPHYRHLGTLPQVVSALQHCGLPVLVVDDGSGEDCRAGLEALREEGVQVAFRPV
NGGKGSAMKWGFKLAAEQGFSHVLQIDADAQHSFADIPRFVETAQSQPQAVVCGRPVYGG
DVPKSRLYGRKITDFWNVLHTWSFDIKDGMCGFRVYPLDAVLPIQYGGAVIGERMDFDNE
ILIRLHWAGTPFIWLDTPVRYEAGGVSHFNLRRDNLLISKMHARLFCGMVARRLCRLFRR
PQTAPTEQAHWSAQRERGHRLFLKITEWLVRYLPLWPVHGIAALVAAYFYLTSAAQRRSV
RQYQGYLRSSFPAAPLPARFPVYRQFAAFGQAVADRFAVWQHKITVPDLVVEDPDNLYAD
VDNHNTRGQILICSHLGNIEVCRALVSHHQGFKLNVLVHNAHAEDFNRALKAAGASDLQL
IQVADLDAAKMLQLSQKLDAGEWLAIAADRTPVRGNKTVPVQFLGHTAHLPQGPWLLAGL
LRAPTNTVFVLKEQGRYHLCLKRFQVAPSWTAATRKQVIENLAQQYADVLAAHAARAPLQ
WFNFYDFWSNTPHG

Enzyme Prediction     

No EC number prediction in MGYG000001625_00134.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	6	125	1.1e-16	0.7176470588235294

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4261	COG4261	5.39e-65	250	548	3	299	Predicted acyltransferase, LPLAT superfamily [General function prediction only].
cd04179	DPM_DPG-synthase_like	3.17e-31	6	185	2	185	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.
cd07984	LPLAT_LABLAT-like	2.10e-23	367	548	20	191	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.
COG1560	HtrB	1.21e-19	268	554	26	302	Lauroyl/myristoyl acyltransferase [Lipid transport and metabolism].
cd06442	DPM1_like	5.42e-13	16	189	16	189	DPM1_like represents putative enzymes similar to eukaryotic DPM1. Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AJE19096.1	0.0	1	554	1	555
SQH50995.1	0.0	1	554	1	555
SNW08172.1	0.0	1	554	1	554
QED92686.1	0.0	1	554	1	554
AZR58711.1	0.0	1	554	14	566

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
C5CBV8	6.92e-10	1	201	1	203	Undecaprenyl-phosphate mannosyltransferase OS=Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) OX=465515 GN=Mlut_12000 PE=1 SV=1
A0QZ12	2.32e-08	2	165	23	193	Polyprenol monophosphomannose synthase OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ppm1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000067	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001625_00134.