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CAZyme Information: MGYG000001625_01705

You are here: Home > Sequence: MGYG000001625_01705

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Eikenella corrodens
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Burkholderiales; Neisseriaceae; Eikenella; Eikenella corrodens
CAZyme ID MGYG000001625_01705
CAZy Family GH102
CAZyme Description Membrane-bound lytic murein transglycosylase A
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
435 46985.38 10.1084
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001625 1812730 MAG China Asia
Gene Location Start: 672;  End: 1979  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 4.2.2.N1

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH102 147 334 1.9e-58 0.9936305732484076

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG2821 MltA 2.24e-125 70 433 34 368
Membrane-bound lytic murein transglycosylase [Cell wall/membrane/envelope biogenesis].
pfam03562 MltA 9.33e-109 74 334 1 231
MltA specific insert domain. This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.
cd14668 mlta_B 1.06e-73 147 334 1 157
Domain B insert of mltA_like lytic transglycosylases. Escherichia coli MltA is a membrane-bound lytic transglycosylase comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which correspond to the 3D domain, named for 3 conserved aspartate residues. Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial lytic transglycosylases (LTs), which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond. Typically, peptidoglycan lytic transglycosylases (LT) are exolytic, releasing Metabolite 1 (GlcNAc-anhMurNAc-L-Ala-D-Glu-m-Dap-D-Ala-D-Ala) from the ends of the PG strands. In contrast, MltE is endolytic , cleaving in the middle of PG strands, with further processing to Metabolite 1 accomplished by other LTs. In E. coli, there are six membrane-bound LTs: MltA-MltF and soluble Slt70. Slt35 is a soluble fragment cleaved from MltB. Bacterial LTs are classified in 4 families: Family 1 includes slt70 MltC-MltF, Family 2 includes MltA, Family 3 includes MltB, and Family 4 of bacteriophage origin. While most of the LT family members are similar in structure and sequence with a lysozyme-like fold, Family 2 (including mltA) is distinct.
smart00925 MltA 1.07e-68 146 334 1 153
MltA specific insert domain. This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.
PRK11162 mltA 9.47e-45 134 428 106 354
murein transglycosylase A; Provisional

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
SNW09325.1 0.0 1 435 1 435
AZR60513.1 1.15e-317 1 435 5 439
QED92511.1 3.46e-317 1 435 5 439
QMT40271.1 3.67e-241 1 435 1 433
ASP17988.1 3.23e-196 7 435 5 437

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2G5D_A 6.32e-176 56 435 35 418
Crystalstructure of MltA from Neisseria gonorrhoeae Monoclinic form [Neisseria gonorrhoeae FA 1090]
2G6G_A 6.45e-171 56 435 35 418
Crystalstructure of MltA from Neisseria gonorrhoeae [Neisseria gonorrhoeae FA 1090]
7ESJ_A 5.02e-88 61 433 22 362
ChainA, membrane-bound lytic murein transglycosylase A [Acinetobacter baumannii],7ESJ_B Chain B, membrane-bound lytic murein transglycosylase A [Acinetobacter baumannii]
6QK4_B 7.04e-80 66 431 28 347
Lytictransglycosylase, LtgG, of Burkholderia pseudomallei. [Burkholderia pseudomallei]
3CZB_A 5.58e-52 65 431 9 342
Crystalstructure of putative transglycosylase from Caulobacter crescentus [Caulobacter vibrioides CB15],3CZB_B Crystal structure of putative transglycosylase from Caulobacter crescentus [Caulobacter vibrioides CB15]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P0A935 1.69e-25 78 428 58 353
Membrane-bound lytic murein transglycosylase A OS=Escherichia coli (strain K12) OX=83333 GN=mltA PE=1 SV=1
P0A936 1.69e-25 78 428 58 353
Membrane-bound lytic murein transglycosylase A OS=Escherichia coli O157:H7 OX=83334 GN=mltA PE=3 SV=1
Q9KPQ4 2.58e-23 230 428 147 349
Membrane-bound lytic murein transglycosylase A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mltA PE=3 SV=1
Q8K9A7 2.47e-19 245 428 177 364
Membrane-bound lytic murein transglycosylase A homolog OS=Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) OX=198804 GN=mltA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000426 0.000142 0.999152 0.000001 0.000311 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001625_01705.