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CAZyme Information: MGYG000001626_01582
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phascolarctobacterium sp900544795 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_C; Negativicutes; Acidaminococcales; Acidaminococcaceae; Phascolarctobacterium; Phascolarctobacterium sp900544795 | |||||||||||
| CAZyme ID | MGYG000001626_01582 | |||||||||||
| CAZy Family | GT8 | |||||||||||
| CAZyme Description | Sensor histidine kinase RcsC | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 48734; End: 50719 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT8 | 3 | 239 | 1.4e-56 | 0.8793774319066148 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd04194 | GT8_A4GalT_like | 5.70e-62 | 5 | 240 | 1 | 248 | A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. |
| COG1442 | RfaJ | 1.52e-49 | 3 | 310 | 1 | 322 | Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]. |
| pfam01501 | Glyco_transf_8 | 1.57e-49 | 6 | 239 | 1 | 249 | Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. |
| cd17546 | REC_hyHK_CKI1_RcsC-like | 8.59e-43 | 540 | 656 | 1 | 113 | phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. |
| PRK11107 | PRK11107 | 3.75e-40 | 307 | 659 | 446 | 784 | hybrid sensory histidine kinase BarA; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QNP76758.1 | 1.24e-199 | 1 | 306 | 1 | 306 |
| BBG64058.1 | 1.43e-178 | 1 | 307 | 1 | 307 |
| QNP77043.1 | 2.02e-178 | 1 | 307 | 1 | 307 |
| SNU93695.1 | 2.66e-42 | 4 | 305 | 22 | 322 |
| BAY25886.1 | 1.27e-40 | 5 | 289 | 1 | 283 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7P8E_A | 4.93e-31 | 311 | 659 | 260 | 643 | ChainA, Receiver domain of histidine kinase [Medicago truncatula] |
| 6QRJ_A | 8.86e-29 | 312 | 659 | 155 | 482 | Crystalstructure of ShkA full-length in complex with AMPPNP [Caulobacter vibrioides CB15] |
| 1SS9_A | 8.03e-20 | 7 | 242 | 3 | 256 | ChainA, alpha-1,4-galactosyl transferase [Neisseria meningitidis] |
| 7P8C_A | 9.41e-20 | 535 | 658 | 5 | 132 | ChainA, Receiver domain of histidine kinase 4 [Arabidopsis thaliana],7P8C_B Chain B, Receiver domain of histidine kinase 4 [Arabidopsis thaliana] |
| 7P8D_A | 1.20e-19 | 535 | 658 | 5 | 132 | ChainA, Receiver domain of histidine kinase 4 [Arabidopsis thaliana],7P8D_B Chain B, Receiver domain of histidine kinase 4 [Arabidopsis thaliana] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q54YZ9 | 1.86e-37 | 288 | 660 | 1490 | 1848 | Hybrid signal transduction histidine kinase J OS=Dictyostelium discoideum OX=44689 GN=dhkJ PE=3 SV=2 |
| P27129 | 1.64e-31 | 5 | 271 | 28 | 304 | Lipopolysaccharide 1,2-glucosyltransferase OS=Escherichia coli (strain K12) OX=83333 GN=rfaJ PE=3 SV=2 |
| P19817 | 3.98e-31 | 3 | 291 | 24 | 322 | Lipopolysaccharide 1,2-glucosyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=rfaJ PE=3 SV=4 |
| Q9C5U0 | 6.63e-31 | 311 | 658 | 690 | 1069 | Histidine kinase 4 OS=Arabidopsis thaliana OX=3702 GN=AHK4 PE=1 SV=1 |
| Q5A599 | 2.07e-30 | 312 | 660 | 661 | 999 | Histidine protein kinase NIK1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NIK1 PE=1 SV=3 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000042 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |