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CAZyme Information: MGYG000001657_00296
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | RC9 sp900760425 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; UBA932; RC9; RC9 sp900760425 | |||||||||||
| CAZyme ID | MGYG000001657_00296 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 11592; End: 13718 Strand: + | |||||||||||
Full Sequence Download help
| MMLLAVVLLL YSCSCRDRKG LAAAREVIGN TVGDVDGITL ELVAPDGDTD SYEIMAKGGK | 60 |
| LEIRGSSPTA ICYAFDRYLR KACRSMVTWS GSNINIPDEW PEYEETAVSP YRFRYFLNVC | 120 |
| TFGYTAPYWN WERWSEEIDW MALHGVNMPL ASVASEAIAK RVWMRLGLTG SEADEFFTGA | 180 |
| AHLPWHRMGN LNSFDGPLDD SWHNSQIELQ HRILDRMRAL GMEPIAPAFA GFVPPAFIER | 240 |
| HPEIKANQLE WGGFDKSENA CVLSPDSPWF SKIGKMFIEE WEKEFGDAKY WISDSFNEMR | 300 |
| LPVDKVDTVG KHRLLAQYGK AIYSSIAAGD PDAVWVTQGW TFGYQHDFWD RESMKALLSE | 360 |
| VPDDRLMIVD LGNDYPKWVW NTEQTWKVQE GFYGKQWIYS YVPNFGGKVL PTGDLDMYAS | 420 |
| GSVEALHSPY AATLAGFGSA PEGLENNEVV YELLADMGWS QENIDLDSWL EGYCIARYGY | 480 |
| CDGRMIQAWK LLRSSVYSSL YSYPRFLWQT VVPDGRRRSR HGINDDFRKA VELFLECADE | 540 |
| CSGSPLYLND AVEFSALWLG ELADRHYVKA LEALEAGRKK EAEAGLDRTV SILMSVDRLL | 600 |
| ASHPDYSLAE WVGYARNAAS DHQVKDRYEA NAKRIITTWG GFQEDYAARF WSGLIADYYI | 660 |
| PRLEVYFSEG QEKLDLWEES WIQRPYTGRT EPYCSPVEKA RKLISEIQ | 708 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 58 | 701 | 2.9e-204 | 0.9894419306184012 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 6.80e-168 | 114 | 461 | 1 | 333 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 9.18e-42 | 469 | 701 | 1 | 258 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 6.01e-21 | 22 | 101 | 1 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AHF12618.1 | 0.0 | 3 | 704 | 11 | 716 |
| QRM99889.1 | 0.0 | 10 | 706 | 15 | 715 |
| QUT31324.1 | 0.0 | 10 | 706 | 15 | 715 |
| ALJ47490.1 | 0.0 | 10 | 706 | 15 | 715 |
| QRQ58948.1 | 0.0 | 10 | 706 | 15 | 715 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4XWH_A | 1.03e-123 | 17 | 666 | 2 | 655 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
| 2VC9_A | 5.64e-88 | 17 | 675 | 167 | 829 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 6.47e-88 | 17 | 675 | 175 | 837 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 5.91e-87 | 17 | 675 | 190 | 852 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P54802 | 1.05e-122 | 17 | 666 | 25 | 678 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| Q9FNA3 | 3.49e-107 | 58 | 682 | 92 | 771 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000332 | 0.020105 | 0.979558 | 0.000011 | 0.000022 | 0.000015 |