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CAZyme Information: MGYG000001657_00297
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | RC9 sp900760425 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; UBA932; RC9; RC9 sp900760425 | |||||||||||
| CAZyme ID | MGYG000001657_00297 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 13722; End: 15953 Strand: + | |||||||||||
Full Sequence Download help
| MNRIFKYIVL IFLAILPASC GDKPVKTDFS VDETRQAALS LVGRVTAGRQ KEFKVVVTGA | 60 |
| QQDGKDWFSV YSEGGKIVLE GNNGVSVASA LNHYLKTWCG WHYTWCGKDT ELPEVLPLPE | 120 |
| EKVTKVSPYK YRYYLNYCTF NYSMSWWDYD RWRQEIDFMA LNGINMPLAV TGQNSVWQRV | 180 |
| YRRLGFTDSQ LESFFSGPAY FNWFWMGNLD GWGGPLPQSF MDRHEELQRN ILFAERSLGM | 240 |
| TPILPAFTGH VPPAFPEMFP DAKVRRTSWV NFPEVAILDP DEELFTEIGR MFIEEQTKIY | 300 |
| GTDHYYTADT FNENLPPLRD SSFLSGMSGK VYSSMSGIDP EAVWVMQGWL FYYARSFWGE | 360 |
| KEIRALLSAV PDDRMLLLDL WSECFPVWNR TEAYYGKPWI WCMLHNFGQN ITMSGNAENV | 420 |
| AKGPSEALHS PLSGKMQGIG LTMEGIGQNP AMYALMLENV WRDTPVDIDT FIGSYFGNRY | 480 |
| GCNDGSAEEA WKIIFRTAFE NGHRNGGHRS IIEGRPTFAS SPGGAISIEP HYDPRELVRA | 540 |
| WDLLISSSGK LSGRDGYRYD LVDVTRQVLA DWSSSLHREV VKAYRSGSPE DFRCSASRFM | 600 |
| ELISDMDRLL STREEFLLGR WLESAKAMGT SPQEKSLYER NARNLLTLWG DRDCPIRDYA | 660 |
| SRQWSGLMNG FYGGRWRLFF DMAYRYLTEG KDMDDFDSLC REWEWDWIHG TETYPDRPCG | 720 |
| DETEVCLGLY EKYRRLMYPE ACE | 743 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 74 | 731 | 1.7e-257 | 0.995475113122172 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 0.0 | 132 | 463 | 1 | 333 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 6.40e-100 | 472 | 725 | 2 | 256 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 1.40e-24 | 36 | 117 | 1 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QJD79315.1 | 4.09e-301 | 36 | 734 | 30 | 729 |
| QCR24959.1 | 5.47e-298 | 36 | 735 | 33 | 732 |
| AHM59799.1 | 1.70e-297 | 32 | 737 | 60 | 766 |
| QKJ30631.1 | 3.86e-296 | 37 | 733 | 32 | 728 |
| QEC44305.1 | 1.63e-291 | 37 | 737 | 33 | 734 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4XWH_A | 6.10e-174 | 32 | 733 | 1 | 711 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
| 2VC9_A | 4.19e-131 | 29 | 705 | 165 | 846 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 5.09e-131 | 29 | 705 | 173 | 854 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 5.57e-130 | 29 | 705 | 188 | 869 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P54802 | 3.05e-174 | 32 | 733 | 24 | 734 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| Q9FNA3 | 9.04e-152 | 74 | 733 | 92 | 804 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000002 | 0.001196 | 0.998837 | 0.000000 | 0.000001 | 0.000000 |