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CAZyme Information: MGYG000001728_00147

You are here: Home > Sequence: MGYG000001728_00147

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA1390 sp002305315
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; UBA1390; UBA1390; UBA1390 sp002305315
CAZyme ID MGYG000001728_00147
CAZy Family GH43
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
816 91346.84 5.8422
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001728 2194259 MAG Sweden Europe
Gene Location Start: 1663;  End: 4113  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000001728_00147.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH43 466 735 6.9e-98 0.9924812030075187

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd08981 GH43_Bt1873-like 4.65e-168 463 745 1 280
Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron BT_1873. This glycosyl hydrolase family 43 (GH43) subfamily includes Bacteroides thetaiotaomicron VPI-5482 endo-arabinase (Bt1873;BT_1873), as well as uncharacterized enzymes similar to those with beta-1,4-xylosidase (xylan 1,4-beta-xylosidase; EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanase and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the GH43 enzymes in this family may display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.
cd08175 G1PDH 5.38e-106 32 446 1 340
Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner. Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.
COG0371 GldA 3.77e-64 35 409 11 359
Glycerol dehydrogenase or related enzyme, iron-containing ADH family [Energy production and conversion].
pfam13685 Fe-ADH_2 4.57e-61 36 308 1 251
Iron-containing alcohol dehydrogenase.
cd08173 Gro1PDH 5.50e-55 35 383 5 321
Sn-glycerol-1-phosphate dehydrogenase (Gro1PDH) catalyzes the reversible conversion between dihydroxyacetone phosphate and glycerol-1-phosphate using either NADH or NADPH as a coenzyme. Sn-glycerol-1-phosphate dehydrogenase (Gro1PDH, EC 1.1.1.261) plays an important role in the formation of the enantiomeric configuration of the glycerophosphate backbone (sn-glycerol-1-phosphate) of archaeal ether lipids. It catalyzes the reversible conversion between dihydroxyacetone phosphate and glycerol-1-phosphate using either NADH or NADPH as a coenzyme. The activity is zinc-dependent. One characteristic feature of archaea is that their cellular membrane has an ether linkage between the glycerol backbone and the hydrocarbon residues. The polar lipids of the members of Archaea consist of di- and tetra-ethers of glycerol with isoprenoid alcohols bound at the sn-2 and sn-3 positions of the glycerol moiety. The archaeal polar lipids have the enantiomeric configuration of a glycerophosphate backbone [sn-glycerol-1-phosphate (G-1-P)] that is the mirror image structure of the bacterial or eukaryal counterpart [sn-glycerol- 3-phosphate (G-3-P)]. The absolute stereochemistry of the glycerol moiety in all archaeal polar lipids is opposite to that of glycerol ester lipids in bacteria and eukarya.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BCZ48739.1 5.96e-110 464 757 4 295
QPC82363.1 4.47e-109 461 756 2 291
AFH64775.1 7.20e-109 461 747 2 280
AEI44682.1 7.20e-109 461 747 2 280
AFR28098.1 7.31e-108 463 756 1 293

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
5C0P_A 5.84e-66 457 753 15 298
Thecrystal structure of endo-arabinase from Bacteroides thetaiotaomicron VPI-5482 [Bacteroides thetaiotaomicron VPI-5482]
5FB3_A 7.91e-25 26 318 3 271
Structureof glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_B Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_C Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_D Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_E Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_F Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548]
4RGQ_A 4.24e-24 115 320 100 297
Crystalstructure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_B Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_C Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_D Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGV_A Crystal structure of the Methanocaldococcus jannaschii G1PDH [Methanocaldococcus jannaschii DSM 2661],4RGV_B Crystal structure of the Methanocaldococcus jannaschii G1PDH [Methanocaldococcus jannaschii DSM 2661]
4RFL_A 4.43e-24 115 320 103 300
Crystalstructure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_B Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_C Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_D Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661]
4QQS_A 3.78e-15 470 738 17 279
Crystalstructure of a thermostable family-43 glycoside hydrolase [Halothermothrix orenii H 168],4QQS_B Crystal structure of a thermostable family-43 glycoside hydrolase [Halothermothrix orenii H 168]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9KBR3 4.07e-51 22 443 15 394
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) OX=272558 GN=egsA PE=3 SV=1
Q65GC3 1.13e-47 22 446 15 385
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) OX=279010 GN=egsA PE=3 SV=1
Q5WL08 7.19e-43 32 405 22 392
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Alkalihalobacillus clausii (strain KSM-K16) OX=66692 GN=egsA PE=3 SV=1
A7Z7G4 1.00e-40 32 320 24 307
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) OX=326423 GN=egsA PE=3 SV=1
B3EYN8 2.29e-40 12 319 5 308
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Geobacillus stearothermophilus OX=1422 GN=egsA PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000060 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001728_00147.