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CAZyme Information: MGYG000001778_01006
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_C; Negativicutes; Acidaminococcales; Acidaminococcaceae; Phascolarctobacterium; | |||||||||||
| CAZyme ID | MGYG000001778_01006 | |||||||||||
| CAZy Family | GT30 | |||||||||||
| CAZyme Description | Tetraacyldisaccharide 4'-kinase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1761; End: 3257 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam02606 | LpxK | 3.87e-86 | 143 | 492 | 5 | 318 | Tetraacyldisaccharide-1-P 4'-kinase. This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N-terminus. |
| PRK00652 | lpxK | 1.13e-71 | 136 | 493 | 12 | 325 | tetraacyldisaccharide 4'-kinase; Reviewed |
| COG1663 | LpxK | 1.77e-62 | 143 | 487 | 20 | 329 | Tetraacyldisaccharide-1-P 4'-kinase [Cell wall/membrane/envelope biogenesis]. |
| TIGR00682 | lpxK | 3.76e-48 | 146 | 469 | 1 | 287 | tetraacyldisaccharide 4'-kinase. Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides] |
| PRK01906 | PRK01906 | 4.30e-30 | 152 | 453 | 33 | 302 | tetraacyldisaccharide 4'-kinase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| BBG63225.1 | 2.82e-301 | 1 | 495 | 346 | 840 |
| QNP77900.1 | 1.14e-300 | 1 | 495 | 346 | 840 |
| QTV78313.1 | 2.79e-272 | 1 | 497 | 346 | 842 |
| AEQ21866.1 | 1.49e-226 | 1 | 498 | 346 | 843 |
| ADB48040.1 | 1.49e-226 | 1 | 494 | 346 | 839 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4EHX_A | 1.58e-42 | 146 | 487 | 9 | 310 | Crystalstructure of LpxK from Aquifex aeolicus at 1.9 angstrom resolution [Aquifex aeolicus VF5],4EHY_A Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITL_A Crystal structure of LpxK from Aquifex aeolicus in complex with AMP-PCP at 2.1 angstrom resolution [Aquifex aeolicus VF5],4ITM_A Crystal structure of 'apo' form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITN_A Crystal structure of 'compact P-loop' LpxK from Aquifex aeolicus in complex with chloride at 2.2 angstrom resolution [Aquifex aeolicus VF5],4LKV_A Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_B Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_C Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_D Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5] |
| 4EHW_A | 1.66e-42 | 146 | 487 | 11 | 312 | Crystalstructure of LpxK from Aquifex aeolicus at 2.3 angstrom resolution [Aquifex aeolicus VF5] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q2LVL1 | 8.04e-73 | 141 | 489 | 25 | 369 | Tetraacyldisaccharide 4'-kinase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxK PE=3 SV=1 |
| B8CZC3 | 1.60e-67 | 122 | 476 | 12 | 371 | Tetraacyldisaccharide 4'-kinase OS=Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) OX=373903 GN=lpxK PE=3 SV=1 |
| B8F928 | 9.10e-65 | 142 | 492 | 26 | 365 | Tetraacyldisaccharide 4'-kinase OS=Desulfatibacillum aliphaticivorans OX=218208 GN=lpxK PE=3 SV=1 |
| A7HDI5 | 1.21e-61 | 137 | 454 | 18 | 326 | Tetraacyldisaccharide 4'-kinase OS=Anaeromyxobacter sp. (strain Fw109-5) OX=404589 GN=lpxK PE=3 SV=1 |
| B4UHQ4 | 4.79e-58 | 160 | 487 | 41 | 359 | Tetraacyldisaccharide 4'-kinase OS=Anaeromyxobacter sp. (strain K) OX=447217 GN=lpxK PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000070 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |