CAZyme Information: MGYG000001911_00060

Basic Information

• Species: Desulfovibrio sp002159665
• Lineage: Bacteria; Desulfobacterota; Desulfovibrionia; Desulfovibrionales; Desulfovibrionaceae; Desulfovibrio; Desulfovibrio sp002159665
• CAZyme ID: MGYG000001911_00060
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
888	MGYG000001911_1|CGC2	98439.07	9.0525

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001911	2704250	MAG	Denmark	Europe

• Gene Location: Start: 81215; End: 83881 Strand: -

Full Sequence      

MLRIPRVRKNQIRKQKREGRILSCLSAGNLSANFGMKLHHTSPDDSFRNTQLPRQNAAEE
QTAQTPPEQQPQEPPKKKRGSFLGAVVRWFFGIMLGLGAIGCAAGFFLYNWVSQDLPDLD
RILDFKAAQATTILARDGSVLGTLSHEKRYVITLDDMPKYLPMAFLAIEDSAFYQHPGIN
PLAILRAMLVNFERGTKSQGGSTITQQIVKQLLLSSERSYVRKMKEAILATRLERELSKD
QILSLYLNYIFLGQQSYGVEAAARTYFGKHAANITLAEACVIAGMPQAPSRYNPFRNPEA
AKARQMEVLNRLRVLEWISEEDYQKAANEPLVYWSMPDKTIGASQWYFEEARRLLIEFFT
ESNLKALGVETNRFGLDYVYEAGLTVQTAMDPLQQQLAGQALRSGLETIDKRQGWRGAIR
QLVSKAEQQAFLDKKNFEPGELADNEWTQALVTSVSPREIHVDLGSGYTGVIRQNNFKWA
NKRSKLAPKARRQGIVSPGDVVWVSLAPRREAAPKKGSKKTVPAESLDNTPVKGVAVELL
LQQEPLVQGAIVSIEPQSGDVVALIGGYQFGESHFNRATQSRRQPGSSFKPIVYSTALDN
GFTPTSSVLDAPIEYVNPATGQIWRPSNFENSYKGEMPLWQALALSRNTPTVRLAQAVGI
DKVIERAKMLGLEPDFPQVLSVSLGAVGVSPLNLTQAYTAFANGGIASRPRIITSIKDSR
GRELYRQEVEQWQAVSPQNAFQVTTLLRRVVENGTGRRAFIDGLHISGKTGTSNDTRDCW
FMGYTPYLCTGVYVGYDQMDSLGSWEQGGRTAAPIFKAYREKADKAYASAPQDMTMPEGI
TMIDGLPYLTENTGPGLSAVDGAVPGAEDSGMPMDTGEDSEMLMRQMF

Enzyme Prediction     

No EC number prediction in MGYG000001911_00060.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	137	312	5.6e-67	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG5009	MrcA	0.0	87	880	5	778	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	148	823	1	528	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	79	878	4	648	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	1.41e-124	93	840	15	799	penicillin-binding protein 1a; Provisional
TIGR02071	PBP_1b	6.47e-111	145	842	143	697	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AMD90698.1	0.0	89	888	13	812
QTO40729.1	0.0	89	888	13	812
QCC86511.1	0.0	89	888	13	812
SPD35918.1	0.0	89	888	13	812
VZH33101.1	0.0	86	888	10	812

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.88e-118	133	875	23	793	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.73e-111	133	816	23	708	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5U2G_A	8.19e-94	114	823	5	757	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
7U4H_A	1.05e-70	129	797	19	736	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
5FGZ_A	1.21e-58	139	840	146	706	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O87626	7.50e-131	116	851	35	730	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O87579	1.67e-128	91	857	10	739	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O86088	1.35e-126	86	857	5	739	Penicillin-binding protein 1A OS=Neisseria cinerea OX=483 GN=mrcA PE=3 SV=1
O05131	7.28e-126	91	857	10	739	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3
Q5FAC7	7.28e-126	91	857	10	739	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000049	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
86	108