CAZyme Information: MGYG000001937_00377

Basic Information

• Species: UBA7173 sp001701135
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae; UBA7173; UBA7173 sp001701135
• CAZyme ID: MGYG000001937_00377
• CAZy Family: GT2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
759	MGYG000001937_3|CGC3	84684.39	5.6456

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001937	2244087	MAG	Denmark	Europe

• Gene Location: Start: 58341; End: 60620 Strand: +

Full Sequence      

MDNTLTNQTGTRASAAAGSPANILRVSPTIGTRQLVDELTSRRDCGAEWQLVALDGYDIE
LSESSRRRLFQLAEDTGALLLYCDYRTSDGPHPLAPYQPGSVRDDFDFGPLMVVSMHLFG
TETAPVESLHSGLYALRLWFAQHSPAAIVHVPEYLYTASVADRRTSGEQQFDYVDPRNAA
VQREREEVFTDYLRRIGAWLDERTFTLSFDEGEFPVEASVIIPVRNRVATVADAVKSALS
QTATFSFNVIVVDNHSTDGTTETLAALAASDSRVVHLIPEETTLGIGGCWEYGVRNAACG
RFAVQLDSDDQYKDSNVLSRIVDCFRTTGAGMVIGSYELTDFDGNPLPPGLIDHKEWTDN
NGHNNALRINGLGAPRAFFTPLLRQIGVPNVSYGEDYALGLRISRRHRIGRIFDSLYLCR
RWSGNSDAALPQERVNANNIYKDLLRSIEIEARKRLAAKEYFQTSRKESRRITEFVDNQL
REWPLARTNTEALANVETRHIEADEFDFRAILNPARAVSSGAKVDAASIAARRCFLCADN
RPDSQEVYPVMEGYEGLVNPYPVFPRHLTIAAVAHTPQSLSDSPGDLRRVADMMELSGRL
PGMVVFYNGAKCGASAPDHMHFQAVRSADLPIFESAAARAFPYRHIFFSVANREQLMSRM
HEIVNVLAMLPENKGEAEPRMNLYMMRRDDRTVDVLVIPRRAHRPACYGTDPGQMLISPG
AIDVAGCFICARECDFRTLDSDSLLKILSDTCYRLRDRD

Enzyme Prediction     

No EC number prediction in MGYG000001937_00377.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	219	352	2.4e-20	0.7647058823529411

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam16269	DUF4922	1.08e-45	589	752	1	181	Domain of unknown function (DUF4922). This family consists of uncharacterized proteins around 310 residues in length and is mainly found in various Bacteroides and Parabacteroides species. Several members are annotated as putative glycosyltransferases, but the specific function of this family is still unknown.
pfam00535	Glycos_transf_2	2.18e-18	219	351	1	129	Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
COG0463	WcaA	1.22e-16	219	410	6	183	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].
cd00761	Glyco_tranf_GTA_type	1.49e-16	220	335	1	113	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
cd04179	DPM_DPG-synthase_like	5.87e-15	220	336	1	115	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ADY35406.1	7.06e-212	59	750	62	777
QJR63544.1	9.51e-198	59	750	85	801
QJR67806.1	9.51e-198	59	750	85	801
QJR56004.1	9.51e-198	59	750	85	801
QJR59198.1	9.51e-198	59	750	85	801

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q92IF9	1.88e-06	219	412	296	482	Uncharacterized glycosyltransferase RC0461 OS=Rickettsia conorii (strain ATCC VR-613 / Malish 7) OX=272944 GN=RC0461 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000032	0.000006	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001937_00377.