CAZyme Information: MGYG000001981_00457

Basic Information

• Species: CAG-617 sp000431275
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; CAG-617; CAG-617 sp000431275
• CAZyme ID: MGYG000001981_00457
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
863		97089.38	8.4029

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001981	2121938	MAG	Spain	Europe

• Gene Location: Start: 50322; End: 52913 Strand: +

Full Sequence      

MSKENQSFWAKVLSAFCWLGRKIKAAWRWYIALYRGTPWYKKLCAAVLSFFAFVIFYIFA
VSVNLFWLFGRSPSINSIMNPRTAAASEIYSEDSVLIGRFFSENRQPVPYDSINPVFFDA
LISTEDERFYRHHGIDFQGLVAAVKDAFRGRARGASTITQQLVKNMFRVRTEYSTGLLGY
IPGVKILVMKSKEMILAVELEMFYSKREILNMYANTVDFGSNAFGIKTASKTYFDTTPSS
LKPEEAAVLVGLLKATSAYNPRINPENSLRRRNTVLDNMRTHGHLTLAECDSLKDLPIDL
KFKVETVYDGKALYFREAVADYLKEKLPDVDLYSDGLKIYTTLNMRMQRYAEAAVSKQMR
IVQRNFDNHWGKRAPWVDERGQEIPHFIEDLAEKTDAYKILSARYPDAPDSVTYYLNQPH
PVKLFTYDGPKTEMMSTMDSIRYMVRFMHTGFVAMEPENGHVKVWVGDIDFQAWKYDKVT
AMRQPGSTFKLFVYTEAMNQGMTPADRMRDEFISMEVYDAKKKETTLWQPHNANGYFSGD
SIPLRAAFARSINTIAVKLGQRVGIDRIAETAHAMGIKSPLDETPALALGASDVNLLEMV
NAYATVANNGRHVEPVLVTKVVDRDGEVIYEATEEGEQVIPYRSAFFMQQLLRAGVNDGG
GTSQSLRRYVGQYAREVDFGGKTGTSNNHSDAWFVGTSPGLVGGAWVGGEYRSIHFRTGA
LGQGSRTALPIFGYFMESVLGDPLFHDKYARKYGAPKEKIDASLYEVTYAPARLDTDTVA
VDSTAVLMGDSLRLELRFDENGVPTLVPVHSADSAGRPAESAGSSQNGVTGGEAKQELNR
RERRKQRRQQDKDGVVQGAQDLI

Enzyme Prediction     

No EC number prediction in MGYG000001981_00457.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	96	280	2e-59	0.9774011299435028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	1.59e-158	104	740	1	529	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.11e-157	35	744	5	601	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	1.73e-148	39	742	1	721	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	6.74e-88	50	740	7	785	penicillin-binding protein 1a; Provisional
TIGR02071	PBP_1b	3.81e-79	93	744	132	687	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALO49868.1	0.0	11	804	3	794
EFC71818.1	0.0	11	818	4	809
QUB46878.1	0.0	11	790	4	791
AGB27916.1	0.0	11	824	3	827
QJR98135.1	0.0	11	804	3	806

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	9.45e-69	75	746	9	729	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.63e-68	88	740	22	716	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5U2G_A	8.27e-59	73	768	8	781	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
3ZG8_B	4.15e-45	199	708	2	431	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
5FGZ_A	6.73e-45	103	744	154	698	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P0A0Z5	2.36e-79	51	740	14	706	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	2.36e-79	51	740	14	706	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1
Q5FAC7	4.49e-79	50	740	13	706	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3
O05131	4.49e-79	50	740	13	706	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3
Q9KNU5	1.23e-76	66	742	27	760	Penicillin-binding protein 1A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcA PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999860	0.000144	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
47	69