CAZyme Information: MGYG000001995_03220

Basic Information

• Species: Parabacteroides sp900541965
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides sp900541965
• CAZyme ID: MGYG000001995_03220
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
696		79465.61	9.0558

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001995	4648473	MAG	Spain	Europe

• Gene Location: Start: 82; End: 2172 Strand: +

Full Sequence      

MVKALIATEDIRFSEHSGIDAQGLFRAVVKRGLLMQKSGGGGSTITQQLAKQLFSPSADN
IMERLFQKPIEWVIAVQLERFYTKEEIVNMYLNKFDFLYNAVGIQSAARVYFGTTPKNLK
IEEAATLIGMCKNPSYFNPVRQPDRTRGRRNTVLEQMEKAGYLSKAECDSLKTLPLTLRF
TRMDHKDGPAPYFREYLRLLMMAKKPERKNYASWQSQKFSEDSLAWETNPLYGWCNKNKK
ADGSNYNIYTDGLKIYTTIDSRMQKYAEEAVQEHFSKTLQPSFFKEKQGRSYAPFSRSVS
TGQVDTMMVRAMHQTDRYRELKKSGMKEDEIRKEFKKPVEMRVFTWSGPRDTIMSPLDSI
RYHKSFLRTGFMSMDPRSGHVKAYVGGIDYNDFQYDMVNGGRRQIGSTIKPFLYSLAMIE
GFSPCDEMLHVQQQLTDENGILWTPRNASAKRIGEKVSIQWGLQNSDNWVTAWLMGQMSP
YTFVRLLHSFGLKNHIDPVISVCLGTPDVSVAEMVSAYTTFANRGIRVEPLYVTHIEDPY
GNTIANFNPQMSEVLTEEASYKMLYMLRSVMDGGTGSRIRFRYGIKAPMGGKTGTTQNNS
DGWFMAFTPSLVSGCWVGGEDRSIHFDRLQDGQGASMALPVYGLYMQKVYADKTLNYSGT
EDFEVPEQYKNPCKTTNEEDRKQIPTDVGGIDKMFE

Enzyme Prediction     

No EC number prediction in MGYG000001995_03220.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	1	158	1.2e-52	0.8587570621468926

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	9.85e-131	2	652	15	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	3.29e-130	1	689	88	631	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	3.62e-119	1	667	79	731	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	7.90e-71	1	672	78	795	penicillin-binding protein 1a; Provisional
TIGR02071	PBP_1b	1.10e-70	1	648	159	681	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUT55103.1	0.0	1	696	86	781
QUR50007.1	0.0	1	696	86	781
ABR43557.1	0.0	1	696	86	781
QRO16257.1	0.0	1	696	86	781
QUT22137.1	0.0	1	696	86	781

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	3.72e-59	2	646	52	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	1.79e-54	2	656	52	729	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3ZG8_B	4.29e-39	77	618	2	431	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
5U2G_A	3.00e-38	1	653	52	761	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	4.02e-35	1	646	168	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	1.43e-63	1	666	75	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
Q9KNU5	1.50e-59	1	652	78	760	Penicillin-binding protein 1A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcA PE=3 SV=2
O87579	1.09e-56	4	647	83	703	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
P70997	6.49e-56	1	623	86	585	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
P0A0Z5	1.57e-54	4	647	83	703	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000046	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001995_03220.