CAZyme Information: MGYG000002040_01474

Basic Information

• Species: Faecalibacterium sp900758465
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Faecalibacterium; Faecalibacterium sp900758465
• CAZyme ID: MGYG000002040_01474
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
764	MGYG000002040_11|CGC1	84291.1	4.4171

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002040	2277187	MAG	China	Asia

• Gene Location: Start: 44492; End: 46786 Strand: -

Full Sequence      

MAGSLAAVGAVYYVVQVTANDGDLLDLDNIELSQSSLVVATDPDTGAQVEYATLRSSNSH
RVWADLEQIPTNLQYAFICTEDKDFYTEPGVNFKRTIGAMINEYLLPIYSSKQGASTLEQ
QLIKNLTSDKSASGIEGALRKLREIYRALILSRSYSKETILEAYLNTISFTGTIQGVQTA
ANEYFNKDVSQLTLWECASIASITKNPTNYNPYTNPENLIHRRNFLLYNMWQQGVISEDD
YRNAAAQPLVLAEEDGSKKSSSTTSYFTDALFNEVVKDIMAKEGVDESTAQSMLYTGGYT
IEATVNPKLQTAMENLMLNADDAYFPAGWHEEEVTSISDDDVQVYNEDGTPKTRTGEDGT
VYYYRNVRTQAAMVTLDYDGNVLAMVGGLGEKTKSLSLNRAYGVTRQTGSTIKPIGAYAL
GIEYGLVNWSTMLNNSPLYLKQDMVIRDEDYCRKNGLMGLTDKQLKAYPNAWRSWPRNYG
GNYGDNSDLPLWNGLARSLNTIAIRVGDLVGASNIFNFVYNTLQLNTLDPVNDVGLAQMV
MGSQTHGVTPMALAAAFQIFYDGEYTTPHLYTRVLDRDGNIYMESNDTSYQALTPQTAYV
MNRLLKNVLFSSVGTASGRYPNSNGMEAFGKTGTASDEKDLWFVGGTPYYVTAVWWGYDA
PYDMTKTLGKQQAKTRTCVMAWKALMEQVQADLPYKAFPTADGVVERSYCTQSGLLASGS
CPSTAVGYYRADDLPDVCNYSHGQAAVSSAPLTSEPDTTSLDTD

Enzyme Prediction     

No EC number prediction in MGYG000002040_01474.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	57	230	8.8e-54	0.943502824858757

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.76e-129	1	760	20	657	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	8.71e-128	60	689	1	528	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	3.60e-109	6	729	20	758	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	3.74e-66	52	659	137	658	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	1.01e-58	60	230	12	176	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AXA81016.1	0.0	1	764	64	827
ATL89188.1	0.0	1	764	49	816
ATO98888.1	0.0	1	764	49	816
QIA44319.1	0.0	1	764	66	833
CBL02306.1	0.0	1	757	59	814

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	1.58e-50	60	729	39	801	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	6.69e-44	69	739	47	772	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	4.57e-43	65	694	43	720	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	4.44e-40	151	659	3	433	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3DWK_A	7.66e-39	53	658	20	557	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q97GR5	3.88e-76	4	706	44	683	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1
A7GHV1	4.52e-73	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A5I6G4	1.71e-72	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	1.71e-72	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
Q891X1	2.38e-72	57	743	76	715	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999995	0.000035	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002040_01474.